Results 171 to 180 of about 4,605 (211)

Decoding color variation: genome-wide characterization and expression analysis of pigment pathways in Neocaridina denticulata. [PDF]

BMC Genomics
Bai S, Ma Z, Gu R, Yang X, Sun Y, Hu J, Bao Z, Qu Z.   +7 more
europepmc   +1 more source

The diagnosis and treatment of disorders of nucleic acid/nucleotide metabolism associated with epilepsy. [PDF]

Acta Epileptol
Shi Y, Wei Z, Feng Y, Gan Y, Li G, Deng Y.   +5 more
europepmc   +1 more source

Biosynthesis of Pteridines. Reaction Mechanism of GTP Cyclohydrolase I

Journal of Molecular Biology, 2003
GTP cyclohydrolase I catalyses the hydrolytic release of formate from GTP followed by cyclization to dihydroneopterin triphosphate. The enzymes from bacteria and animals are homodecamers containing one zinc ion per subunit. Replacement of Cys110, Cys181, His112 or His113 of the enzyme from Escherichia coli by serine affords catalytically inactive ...
Andreas Bracher, Herbert Nar, Nicholas Schramek   +2 more
exaly   +6 more sources

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GTP Cyclohydrolase I Feedback Regulatory Protein-Dependent and -Independent Inhibitors of GTP Cyclohydrolase I

Archives of Biochemistry and Biophysics, 2001
GTP cyclohydrolase I feedback regulatory protein (GFRP) mediates the feedback inhibition of GTP cyclohydrolase I activity by (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin (BH4) through protein complex formation. Since guanine and BH4 have a common pyrimidine ring structure, we examined the inhibitory effect of guanine and its analogs on the enzyme ...
Toshie Yoneyama, Kazuyuki Hatakeyama
exaly   +3 more sources

Increase of GTP cyclohydrolase I activity in mononuclear blood cells by stimulation: detection of heterozygotes of GTP cyclohydrolase I deficiency

Clinica Chimica Acta, 1985
An assay is described for GTP cyclohydrolase I activity in human mononuclear cells isolated from 20 ml of heparinized blood. The activity of this enzyme was low in unstimulated cells and increased 5-10 times after stimulation by phytohemagglutinin (formation of 0.8-1.3 pmol dihydroneopterin triphosphate/min per mg protein at 37 degrees C, n = 15) or ...
Nenad Blau, Alois Niederwieser, A Niederwieser   +2 more
exaly   +3 more sources

Species and tissue specificity of mammalian GTP cyclohydrolase I messenger RNA

Biochimica Et Biophysica Acta Gene Regulatory Mechanisms, 1992
Northern blot analysis of rat RNA from cell lines and isolated organs with a specific rat cDNA probe detected two GTP cyclohydrolase I mRNA species of approx. 1.4 and 3.6 kb. The ratio between these two species varies between 0.6 and 2.4 in different rat
Markus Gütlich, Karin Schott, Thomas Werner   +2 more
exaly   +2 more sources

Occurrence of GTP Cyclohydrolase I in

The Journal of Biochemistry, 1979
A GTP cyclohydrolase which catalyzes the removal of carbon 8 of GTP as formic acid to yield a single pteridine compound occurs in an obligate thermophile Bacillus stearothermophilus ATCC 8005. The enzyme was purified 5.5-fold. Its molecular weight and Stoke's radius were estimated as 105,000 and 45.3 A, respectively. The Km for GTP was 0.98 microM. The
Yuzuru SUZUKI, Tadashi YASUI, Shigeo ABE
openaire   +2 more sources

Inhibition of GTP cyclohydrolase I by pterins

Biochimica et Biophysica Acta (BBA) - General Subjects, 1988
Pterins inhibit rat liver GTP cyclohydrolase I activity noncompetitively. Reduced pterins, such as 7,8-dihydro-D-neopterin, (6R,S)-5,6,7,8-tetrahydro-D-neopterin, 7,8-dihydro-L-biopterin, (6R)-5,6,7,8-tetrahydro-L-biopterin, L-sepiapterin, and DL-6-methyl-5,6,7,8-tetrahydropterin are approximately 12-times more potent as inhibitors than are oxidized ...
R S, Shen, A, Alam, Y X, Zhang
openaire   +2 more sources

GTP-cyclohydrolase-I like immunoreactivity in rat brain [PDF]

Brain Research, 1997
GTPCH-I immunoreactive structures in the rat brain were studied using a polyclonal antibody raised in the chick. General mapping was made using the avidin-biotin-peroxidase technique and compared with the distribution of tyrosine hydroxylase and serotonin immunoreactivities.
Dassesse, Donald, Cuvelier, Laetitia, Grégoire, Anne, Hemmens, Benjamin   +3 more
openaire   +2 more sources