Results 11 to 20 of about 129,543 (335)

ADP-Ribosylation Factor Family of Small GTP-Binding Proteins: Their Membrane Recruitment, Activation, Crosstalk and Functions

Frontiers in Cell and Developmental Biology, 2022
Members of the ADP-ribosylation factor (ARF) family of guanine-nucleotide binding proteins play critical roles in various cellular processes, especially in regulating the secretory, and endocytic pathways.
Tiantian Li, Yusong Guo, Yusong Guo, Yusong Guo   +3 more
doaj   +1 more source

GTPase-Activating Proteins for Cdc42 [PDF]

Eukaryotic Cell, 2002
ABSTRACT The Rho-type GTPase, Cdc42, has been implicated in a variety of functions in the yeast life cycle, including septin organization for cytokinesis, pheromone response, and haploid invasive growth. A group of proteins called GTPase-activating proteins (GAPs) catalyze the hydrolysis of GTP to GDP, thereby inactivating Cdc42.
Gregory R, Smith, Scott A, Givan, Paul, Cullen, George F, Sprague   +3 more
openaire   +2 more sources

Barley ROP-Interactive Partner-a organizes into RAC1- and MICROTUBULE-ASSOCIATED ROP-GTPASE ACTIVATING PROTEIN 1-dependent membrane domains

BMC Plant Biology, 2020
Background Small ROP (also called RAC) GTPases are key factors in polar cell development and in interaction with the environment. ROP-Interactive Partner (RIP) proteins are predicted scaffold or ROP-effector proteins, which function downstream of ...
Caroline Hoefle, Christopher McCollum, Ralph Hückelhoven   +2 more
doaj   +1 more source

A screening-compatible live cell fluorescence resonance energy transfer-based assay for modulation of Rho GTPase activity

STAR Protocols, 2022
Summary: Rho family GTPases are central regulators of cytoskeletal dynamics controlled by guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating proteins (RhoGAPs).
Paul Markus Müller, Oliver Rocks
doaj   +1 more source

C9orf72 Toxic Species Affect ArfGAP-1 Function

Cells, 2023
Compelling evidence indicates that defects in nucleocytoplasmic transport contribute to the pathogenesis of amyotrophic lateral sclerosis (ALS). In particular, hexanucleotide (G4C2) repeat expansions in C9orf72, the most common cause of genetic ALS, have
Simona Rossi, Michela Di Salvio, Marilisa Balì, Assia De Simone, Savina Apolloni, Nadia D’Ambrosi, Ivan Arisi, Francesca Cipressa, Mauro Cozzolino, Gianluca Cestra   +9 more
doaj   +1 more source

Turning Platelets Off and On: Role of RhoGAPs and RhoGEFs in Platelet Activity

Frontiers in Cardiovascular Medicine, 2022
Platelet cytoskeletal reorganisation is a critical component of platelet activation and thrombus formation in haemostasis. The Rho GTPases RhoA, Rac1 and Cdc42 are the primary drivers in the dynamic reorganisation process, leading to the development of ...
Shane P. Comer, Shane P. Comer
doaj   +1 more source

Upregulation of DAB2IP Inhibits Ras Activity and Tumorigenesis in Human Pancreatic Cancer Cells

Technology in Cancer Research & Treatment, 2020
KRAS mutation-induced Ras activation plays an important role in the pathogenesis of pancreatic cancer, but the role of wild-type Ras and Ras GTPase-activating proteins remains unclear. The present study was designed to determine the expression spectra of
Yifan Duan MD, PhD, Xiaoyu Yin MD, PhD, Xiaorong Lai MD, PhD, Chao Liu MD, PhD, Wenjing Nie MD, MM, Dongfeng Li MM, Zijun Xie MD, PhD, Zijun Li MD, PhD, Fan Meng MD, PhD   +8 more
doaj   +1 more source

Niemann-Pick Type C Proteins Are Required for Sterol Transport and Appressorium-Mediated Plant Penetration of Colletotrichum orbiculare

mBio, 2022
Many biotrophic and hemibiotrophic fungal pathogens use appressoria to directly penetrate the host plant surface. In the cucumber anthracnose fungus Colletotrichum orbiculare, differentiation of appressoria requires a proper G1/S cell cycle progression ...
Sayo Kodama, Naoki Kajikawa, Fumi Fukada, Yasuyuki Kubo   +3 more
doaj   +1 more source

Rho GTPase Regulators and Effectors in Autism Spectrum Disorders: Animal Models and Insights for Therapeutics

Cells, 2020
The Rho family GTPases are small G proteins that act as molecular switches shuttling between active and inactive forms. Rho GTPases are regulated by two classes of regulatory proteins, guanine nucleotide exchange factors (GEFs) and GTPase-activating ...
Daji Guo, Xiaoman Yang, Lei Shi
doaj   +1 more source

Granule Cell Dispersion in Human Temporal Lobe Epilepsy: Proteomics investigation of neurodevelopmental migratory pathways [PDF]

, 2020
Granule cell dispersion (GCD) is a common pathological feature observed in the hippocampus of patients with Mesial Temporal Lobe Epilepsy (MTLE). Pathomechanisms underlying GCD remain to be elucidated, but one hypothesis proposes aberrant reactivation of
Al-Kaaby, B., Al-Kaaby, B., Dzurova, N., Dzurova, N., Liu, J., Liu, J., Millks, K., Millks, K., Sisodiya, S.M., Sisodiya, S.M., Thom, M., Thom, M.   +11 more
core   +1 more source