Results 11 to 20 of about 13,809 (125)
Computational model explains high activity and rapid cycling of Rho GTPases within protein complexes. [PDF]
PLoS Computational Biology, 2006 Formation of multiprotein complexes on cellular membranes is critically dependent on the cyclic activation of small GTPases. FRAP-based analyses demonstrate that within protein complexes, some small GTPases cycle nearly three orders of magnitude faster ...
Andrew B Goryachev, Alexandra V Pokhilko
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Frontiers in Cell and Developmental Biology, 2021 Membrane trafficking is critical for cellular homeostasis, which is mainly carried out by small GTPases, a class of proteins functioning in vesicle budding, transport, tethering and fusion processes. The accurate and organized membrane trafficking relies
Zehui Lei +5 more
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Dependence of protein-induced lipid bilayer deformations on protein shape [PDF]
, 2022 Membrane proteins typically deform the surrounding lipid bilayer membrane, which can play an important role in the function, regulation, and organization of membrane proteins. Membrane elasticity theory provides a beautiful description of protein-induced lipid bilayer deformations, in which all physical parameters can be directly determined from ...
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p190RhoGAPs, the ARHGAP35- and ARHGAP5-Encoded Proteins, in Health and Disease
Cells, 2019 Small guanosine triphosphatases (GTPases) gathered in the Rat sarcoma (Ras) superfamily represent a large family of proteins involved in several key cellular mechanisms.
Capucine Héraud +3 more
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Ras GTPase-activating proteins control neuronal circuit development in barrel cortex layer 4
Frontiers in Neuroscience, 2022 The cerebral cortex comprises a complex and exquisite network of neuronal circuits that is formed during development. To explore the molecular mechanisms involved in cortical circuit formation, the tactile somatosensory pathway that connects the whiskers
Madhura S. Rao +7 more
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Fixing the GAP: The role of RhoGAPs in cancer
European Journal of Cell Biology, 2022 Cancer progression and metastasis are processes that involve significant cellular changes. Many of these changes include alterations in the activity of the Rho GTPase family of proteins.
Gabriel Kreider-Letterman +2 more
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F1000Research, 2016 Rho GTPases are crucial signaling molecules that regulate a plethora of biological functions. Traditional biochemical, cell biological, and genetic approaches have founded the basis of Rho GTPase biology.
Rafael Dominik Fritz, Olivier Pertz
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Binding of anisotropic curvature-inducing proteins onto membrane tubes [PDF]
Soft Matter 18, 3384-3394 (2022), 2022 Bin/Amphiphysin/Rvs superfamily proteins and other curvature-inducing proteins have anisotropic shapes and anisotropically bend biomembrane. Here, we report how the anisotropic proteins bind the membrane tube and are orientationally ordered using mean-field theory including an orientation-dependent excluded volume.
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Curvature sensing of curvature-inducing proteins with internal structure [PDF]
Phys. Rev. E 109, 024403 (2024), 2023 Many types of peripheral and transmembrane proteins can sense and generate membrane curvature. Laterally isotropic proteins and crescent proteins with twofold rotational symmetry, such as Bin/Amphiphysin/Rvs superfamily proteins, have been studied theoretically. However, proteins often have an asymmetric structure or a higher rotational symmetry.
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Roles of Rap1 signaling in tumor cell migration and invasion
Cancer Biology & Medicine, 2017 Ras-associated protein-1 (Rap1), a small GTPase in the Ras-related protein family, is an important regulator of basic cellular functions (e.g., formation and control of cell adhesions and junctions), cellular migration, and polarization.
Yi-Lei Zhang +4 more
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