Results 21 to 30 of about 1,011,564 (289)
Roles of G proteins and their GTPase-activating proteins in platelets. [PDF]
Biosci RepAbstractPlatelets are small anucleate blood cells supporting vascular function. They circulate in a quiescent state monitoring the vasculature for injuries. Platelets adhere to injury sites and can be rapidly activated to secrete granules and to form platelet/platelet aggregates.
O'Donoghue L, Smolenski A.
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Frontiers in Cell and Developmental Biology, 2022 Members of the ADP-ribosylation factor (ARF) family of guanine-nucleotide binding proteins play critical roles in various cellular processes, especially in regulating the secretory, and endocytic pathways.
Tiantian Li +3 more
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Modulation of small GTPase activity by NME proteins [PDF]
Laboratory Investigation, 2018 NME proteins are reported to influence signal transduction activity of small GTPases from the Ras superfamily by diverse mechanisms in addition to their generic NDP kinase activity, which replenishes the cytoplasmic pool of GTP. Comprehensive evidence shows that NME proteins modulate the activity of Ras GTPases, in particular members of the Rho family,
Vedrana Filić +3 more
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Turning Platelets Off and On: Role of RhoGAPs and RhoGEFs in Platelet Activity
Frontiers in Cardiovascular Medicine, 2022 Platelet cytoskeletal reorganisation is a critical component of platelet activation and thrombus formation in haemostasis. The Rho GTPases RhoA, Rac1 and Cdc42 are the primary drivers in the dynamic reorganisation process, leading to the development of ...
Shane P. Comer, Shane P. Comer
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The role of GTPase-activating protein ARHGAP26 in human cancers [PDF]
Molecular and Cellular Biochemistry, 2021 AbstractRho GTPases are molecular switches that play an important role in regulating the behavior of a variety of tumor cells. RhoA GTPase-activating protein 26 (ARHGAP26) is a GTPase-activating protein and inhibits the activity of Rho GTPases by promoting the hydrolytic ability of Rho GTPases.
Lingye Zhang +6 more
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BMC Plant Biology, 2020 Background Small ROP (also called RAC) GTPases are key factors in polar cell development and in interaction with the environment. ROP-Interactive Partner (RIP) proteins are predicted scaffold or ROP-effector proteins, which function downstream of ...
Caroline Hoefle +2 more
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RAP1GAP (RAP1 GTPase activating protein) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on RAP1GAP (RAP1 GTPase activating protein), with data on DNA, on the protein encoded, and where the gene is implicated.
Chen, Z, Shao, X
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C9orf72 Toxic Species Affect ArfGAP-1 Function
Cells, 2023 Compelling evidence indicates that defects in nucleocytoplasmic transport contribute to the pathogenesis of amyotrophic lateral sclerosis (ALS). In particular, hexanucleotide (G4C2) repeat expansions in C9orf72, the most common cause of genetic ALS, have
Simona Rossi +9 more
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A Novel GTPase-activating Protein for R-Ras [PDF]
Journal of Biological Chemistry, 1995 R-Ras, belonging to the Ras small GTP-binding protein superfamily, has been implicated in regulation of various cell functions such as gene expression, cell proliferation, and apoptotic cell death. In the present study, we purified an R-Ras-interacting protein with molecular mass of about 98 kDa (p98) from bovine brain cytosol by glutathione S ...
Masato Nakafuku +4 more
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mBio, 2022 Many biotrophic and hemibiotrophic fungal pathogens use appressoria to directly penetrate the host plant surface. In the cucumber anthracnose fungus Colletotrichum orbiculare, differentiation of appressoria requires a proper G1/S cell cycle progression ...
Sayo Kodama +3 more
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