Results 21 to 30 of about 13,809 (125)
Phosphoproteome Profiling of SH-SY5y Neuroblastoma Cells Treated with Anesthetics: Sevoflurane and Isoflurane Affect the Phosphorylation of Proteins Involved in Cytoskeletal Regulation. [PDF]
PLoS ONE, 2016 Inhalation anesthetics are used to decrease the spinal cord transmission of painful stimuli. However, the molecular or biochemical processes within cells that regulate anesthetic-induced responses at the cellular level are largely unknown.
Joomin Lee +3 more
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mBio, 2014 Pseudomonas aeruginosa is a Gram-negative pathogen commonly associated with nosocomial infections such as hospital-acquired pneumonia. It uses a type III secretion system to deliver effector proteins directly into the cytosol of host cells.
Stephanie M. Rangel +2 more
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Antibody-validated proteins in inflamed islets of fulminant type 1 diabetes profiled by laser-capture microdissection followed by mass spectrometry. [PDF]
PLoS ONE, 2014 There are no reports of proteomic analyses of inflamed islets in type 1 diabetes.Proteins expressed in the islets of enterovirus-associated fulminant type 1 diabetes (FT1DM) with extensive insulitis were identified by laser-capture microdissection mass ...
Yoriko Nishida +3 more
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Rab11 and Its Role in Neurodegenerative Diseases
ASN Neuro, 2022 Vesicles mediate the trafficking of membranes/proteins in the endocytic and secretory pathways. These pathways are regulated by small GTPases of the Rab family.
Pinky Sultana, Jiri Novotny
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In silico evidence that protein unfolding is as a precursor of the protein aggregation [PDF]
ChemPhysChem 2020, 21, 377, 2019 We present a computational study on the folding and aggregation of proteins in aqueous environment, as function of its concentration. We show how the increase of the concentration of individual protein species can induce a partial unfolding of the native conformation without the occurrence of aggregates. A further increment of the protein concentration
arxiv +1 more source
Cells, 2021 Rho family guanosine triphosphatases (GTPases) regulate cellular signaling and cytoskeletal dynamics, playing a pivotal role in cell adhesion, migration, and cell cycle progression.
Marcello Scala +3 more
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A novel methodology on distributed representations of proteins using their interacting ligands [PDF]
Bioinformatics 2018, 2018 The effective representation of proteins is a crucial task that directly affects the performance of many bioinformatics problems. Related proteins usually bind to similar ligands. Chemical characteristics of ligands are known to capture the functional and mechanistic properties of proteins suggesting that a ligand based approach can be utilized in ...
arxiv +1 more source
STAR Protocols, 2022 Summary: Rho family GTPases are central regulators of cytoskeletal dynamics controlled by guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating proteins (RhoGAPs).
Paul Markus Müller, Oliver Rocks
doaj
eLife, 2020 Retromer, including Vps35, Vps26, and Vps29, is a protein complex responsible for recycling proteins within the endolysosomal pathway. Although implicated in both Parkinson’s and Alzheimer’s disease, our understanding of retromer function in the adult ...
Hui Ye +10 more
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GTP Binding Assays in Arabidopsis thaliana
Bio-Protocol, 2013 Signaling through G proteins constitutes an ancient mechanism that functions in the transduction of extracellular signals into intracellular responses. Activation of a proper receptor by a stimuli leads to an exchange of GDP for GTP, the activation of G ...
Ana Fox, Maria Mazzella
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