Results 11 to 20 of about 61,842 (198)
Journal of Cell Biology, 2021 Borchers et al. review regulatory principles in the activation of endocytic Rab GTPases and how they apply to other Rab and Arf GTPases.
Ann-Christin Borchers +2 more
semanticscholar +1 more source
Targeting Rho GTPase Signaling Networks in Cancer
Frontiers in Cell and Developmental Biology, 2020 As key regulators of cytoskeletal dynamics, Rho GTPases coordinate a wide range of cellular processes, including cell polarity, cell migration, and cell cycle progression.
Natasha S. Clayton, A. Ridley
semanticscholar +1 more source
Targeting the Small GTPase Superfamily through Their Regulatory Proteins
Angewandte Chemie, 2020 The Ras superfamily of small GTPases are guanine‐nucleotide‐dependent switches essential for numerous cellular processes. Mutations or dysregulation of these proteins are associated with many diseases, but unsuccessful attempts to target the small ...
J. Gray, F. Delft, P. Brennan
semanticscholar +1 more source
The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway
Cell, 1992 Cecilia Bucci +6 more
openalex +2 more sources
Rho GTPase signaling complexes in cell migration and invasion
Journal of Cell Biology, 2018 Cell migration is dependent on the dynamic formation and disassembly of actin filament–based structures, including lamellipodia, filopodia, invadopodia, and membrane blebs, as well as on cell–cell and cell–extracellular matrix adhesions.
C. Lawson, A. Ridley
semanticscholar +1 more source
Developmental control of plant Rho GTPase nano-organization by the lipid phosphatidylserine
Science, 2019 GTPase clustering in response to a hormone Some lipid variants that are rare in plasma membranes function as signaling components. Studying root tip cells of the model plant Arabidopsis, Platre et al.
M. Platre +12 more
semanticscholar +1 more source
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling.
Genes & Development, 2003 Tuberous sclerosis complex (TSC) is a genetic disease caused by mutation in either TSC1 or TSC2. The TSC1 and TSC2 gene products form a functional complex and inhibit phosphorylation of S6K and 4EBP1.
K. Inoki, Yong Li, Tian Xu, K. Guan
semanticscholar +1 more source
Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex
Science, 2019 Cellular response to nutrient status An intricate regulatory mechanism is taking shape around control of the mechanistic target of rapamycin complex 1 (mTORC1) protein kinase complex. Physiological responses of cells to nutrient abundance is regulated by
R. Lawrence +10 more
semanticscholar +1 more source
Critical appraisal on mitochondrial dysfunction in Alzheimer’s disease
AGING MEDICINE, Volume 5, Issue 4, Page 272-280, December 2022., 2022 Amyloid plaques deposit on neurons in case of Alzheimer's Disease. Mitochondria play a vital role in pathogenesis of Alzheimer's Disease. Mitochondrial dysfunction can lead to formation of mPTP, alteration of complexes 1,3 and 4, deficits in bioenergetics with impaired mitochondrial biogenesis. Abstract It is widely recognized that Alzheimer's disease (
Faizan Ahmad, Punya Sachdeva
wiley +1 more source
Multiple Roles of the Small GTPase Rab7
Cells, 2016 Rab7 is a small GTPase that belongs to the Rab family and controls transport to late endocytic compartments such as late endosomes and lysosomes. The mechanism of action of Rab7 in the late endocytic pathway has been extensively studied.
Flora Guerra, C. Bucci
semanticscholar +1 more source