Results 11 to 20 of about 322,041 (407)
GTPases and the origin of the ribosome [PDF]
Biology Direct, 2010 This paper is an attempt to trace the evolution of the ribosome through the evolution of the universal P-loop GTPases that are involved with the ribosome in translation and with the attachment of the ribosome to the membrane. The GTPases involved in translation in Bacteria/Archaea are the elongation factors EFTu/EF1, the initiation factors IF2/aeIF5b +
Smith, Temple F., Hartman, Hyman
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WormBook, 2018 Members of the protein superfamily of small guanosine triphosphatases, also known as small GTPases, small G-proteins, or the Ras superfamily, are involved in nearly every aspect of cell biology. Small GTPases are tightly regulated molecular switches that make binary on/off decisions through controlled loading of GTP (activation) and hydrolysis of GTP ...
David J, Reiner, Erik A, Lundquist
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Current Protocols, 2023 AbstractIn different cellular activities like signal transduction, cell division, and intracellular transportation, small GTPases take on a vital role. Their functioning involves hydrolysing guanosine triphosphate (GTP) to guanosine diphosphate (GDP).
Sophie Tschirpke +2 more
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Targeting Rho GTPase Signaling Networks in Cancer
Frontiers in Cell and Developmental Biology, 2020 As key regulators of cytoskeletal dynamics, Rho GTPases coordinate a wide range of cellular processes, including cell polarity, cell migration, and cell cycle progression.
Natasha S. Clayton, A. Ridley
semanticscholar +1 more source
Journal of Cell Science, 2007 It has been two decades since the yeast Ypt1 and Sec4 proteins and the mammalian Rab (Ras-related proteins in brain) GTPases were first identified as evolutionarily conserved, essential regulators of membrane trafficking ([Salminen and Novick, 1987][1]; [Schmitt et al., 1986][2]; [Touchot et al.,
Schwartz, Samantha +4 more
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Targeting the Small GTPase Superfamily through Their Regulatory Proteins
Angewandte Chemie, 2020 The Ras superfamily of small GTPases are guanine‐nucleotide‐dependent switches essential for numerous cellular processes. Mutations or dysregulation of these proteins are associated with many diseases, but unsuccessful attempts to target the small ...
J. Gray, F. Delft, P. Brennan
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GTPase Networks in Membrane Traffic
Annual Review of Biochemistry, 2012 Emi Mizuno-Yamasaki +2 more
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A mechanism for the response of KRASG13D expressing colorectal cancers to EGFR inhibitors
Molecular & Cellular Oncology, 2020 Previous analysis of Phase 3 clinical trial data for colorectal cancer patients treated with cetuximab revealed that patients harboring a KRAS mutation did not benefit from treatment.
Thomas McFall, Edward Cooper Stites
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eLife, 2020 Ventral furrow formation, the first step in Drosophila gastrulation, is a well-studied example of tissue morphogenesis. Rho1 is highly active in a subset of ventral cells and is required for this morphogenetic event.
Ashley Rich +2 more
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The Impact of the Stringent Response on TRAFAC GTPases and Prokaryotic Ribosome Assembly
Cells, 2019 Many facets of ribosome biogenesis and function, including ribosomal RNA (rRNA) transcription, 70S assembly and protein translation, are negatively impacted upon induction of a nutrient stress-sensing signalling pathway termed the stringent response ...
Daniel J. Bennison +2 more
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