Results 221 to 230 of about 261,647 (345)

Various methods to detect small GTPase activation: from radioisotope-based methods to the Small GTPase ActIvitY ANalysing (SAIYAN) system. [PDF]

J Biochem
Maeda M, Saito K.
europepmc   +1 more source

Structure-function relationship of the small GTPase rab5.

, 1993
Guangpu Li, Philip D. Stahl
openalex   +1 more source

ARC Expands the DAAM1 Microexon‐Mediated Actin–RHOA/ROCK Interplay

Cytoskeleton, EarlyView.
ABSTRACT Actin cytoskeleton and its dynamics play a crucial role in synaptic function, influencing dendritic spines' structural and functional plasticity. Recent findings unveiled the significance of alternative splicing of a neural‐specific microexon in DAAM1 in modulating actin's role in synaptic processes.
Patryk Poliński, Marta Miret Cuesta, Manuel Irimia   +2 more
wiley   +1 more source

Bacteria-Mediated Anomalous Rho GTPase Activation Alters Sperm Structure and Provokes Premature Capacitation Events: A Possible Mechanism of Infertility. [PDF]

Int J Mol Sci
Rivera B, Aroca C, González B, Guzmán N, Letelier P, Uribe P, Fornés M, Villegas JV, Boguen R.   +8 more
europepmc   +1 more source

Purification of GTPase-activating protein specific for the rho gene products.

, 1991
Narito Morii, Kenichi Kawano, Akihiro Sekine, Takaaki Yamada, Shuh Narumiya   +4 more
openalex   +1 more source

Introduction toSmall GTPases [PDF]

Small GTPases, 2010
Williams, Michael J., Rottner, Klemens
openaire   +4 more sources

Novel Para‐Phenylenediamine‐Based Derivatives as Receptor Tyrosine Kinase‐like Orphan Receptor 1 (ROR1) Inhibitors: An In Vitro Preliminary Characterization

ChemMedChem, EarlyView.
ROR1 represents a promising target for the development of novel antiproliferative compounds, giving its high expression in different cancer cell lines. The present study describes the workflow leading to the design, synthesis, and characterization of a series of para‐phenylenediamine‐based compounds able to interact with the target kinase, inhibiting ...
Gerardina Smaldone, Maria Rosaria Miranda, Francesca Di Matteo, Valeria Napolitano, Michela Aliberti, Simona Musella, Veronica Di Sarno, Gianluigi Lauro, Giuseppe Bifulco, Giacomo Pepe, Giovanna Aquino, Mario Felice Tecce, Isabel Maria Gomez‐Monterrey, Pietro Campiglia, Carmine Ostacolo, Alessia Bertamino, Vincenzo Vestuto, Tania Ciaglia   +17 more
wiley   +1 more source

Activation of RHO-GTPase gene pattern correlates with adverse clinical outcome and immune microenvironment in clear cell renal cell carcinoma. [PDF]

Clin Exp Med
Guo K, Ma P, Yang Q, Xu L, Zhang B, Zhang H, Zheng Z, Zhuo Z.   +7 more
europepmc   +1 more source

Inhibition of the clathrin terminal domain – amphiphysin protein‐protein interaction. Probing the Pitstop® 2 aromatic moiety.

ChemMedChem, Accepted Article.
Pitstop 2, (Z)‐N‐(5‐(4‐bromenzylidene)‐4‐oxo‐4,5‐dihydrothiazol‐2‐yl)naphthalene‐1‐sulfonamide (1), inhibits the clathrin terminal domain‐ amphiphysin interaction (NTD‐PPI) and has been widely used to investigate endocytosis. In this work we report on the synthesis of 56 novel Pitstop 2 analogues via four discrete focused libraries.
Kate Prichard, Mark J Robertson, Ngoc Chau, Jing Xue, Martin Neuenschwander, Uwe Fink, Andre Horatscheck, Marc Nazare, Phillip J Robinson, Volker Haucke, Adam McCluskey   +10 more
wiley   +1 more source

The biochemical mechanism of Rho GTPase membrane binding, activation and retention in activity patterning. [PDF]

EMBO J
Armstrong MC, Weiß YR, Hoachlander-Hobby LE, Roy AA, Visco I, Moe A, Golding AE, Hansen SD, Bement WM, Bieling P.   +9 more
europepmc   +1 more source