Results 251 to 260 of about 274,715 (359)

Phosphoproteomics unveils the signaling dynamics in neuronal cells stimulated with insulin and insulin-like growth factors. [PDF]

Cell Commun Signal
Ushakumary MG, Sontag RL, Posso C, Fillmore TL, Topping ME, Olson HM, De Jager PL, Bennett DA, Arvanitakis Z, Petyuk VA.   +9 more
europepmc   +1 more source

PVT1 lincRNA signals an androgen‐dependent transcriptional activation program of oncogenes in prostate cancer cells

International Journal of Cancer, EarlyView.
What's New? Unraveling the networks that regulate androgen receptor (AR) function is critical to better understanding prostate cancer development and progression. Of particular interest in this regard is the long non‐coding RNA PVT1, which regulates gene expression in cancer and is upregulated in prostate tumors.
Maria Gabriela Berzoti‐Coelho, Fabio Nunes de Mello, Ana Carolina Tahira, Gabriel Nakanishi Fortes, Agatha Fischer‐Carvalho, Pedro Jardim Poli, Murilo Sena Amaral, Sergio Verjovski‐Almeida   +7 more
wiley   +1 more source

miR-22-Galectin-1 as an integral signaling axis in regulating metabolism and immunity in HCC. [PDF]

Biomark Res
Hu Y, Setayesh T, Jena PK, Ji Y, Testerman T, Liu R, Shih TC, Wang XJ, Liu FT, Lam KS, Wan YY.   +10 more
europepmc   +1 more source

Holistic bone developing microenvironment engineered apoptotic extracellular vesicles recapitulate multidimensional developmental signatures in adult and senile bone repair

Interdisciplinary Medicine, EarlyView.
The developing bone was identified as an M2a‐like macrophage driven immune microenvironment with multidimensional developmental signatures. hME‐ApoEVs were successfully fabricated via stimulating the M2a‐like developing microenvironment in vitro and confirmed its recapitulation of developmental features.
Xiaoran Yu, Jieyun Xu, Yuan Zhao, Xinyu Guo, Hongcheng Chen, Junlong Xue, Yong Ao, Linjun Zhang, Xiaomeng Gao, Xueli Mao, Songtao Shi, Zetao Chen   +11 more
wiley   +1 more source

Experimental Validation of an Immune Cell Infiltration Signature in Psoriasis: Translating Computational Modeling to In Vivo Efficacy

Journal of Clinical Laboratory Analysis, EarlyView.
We calculated the infiltration profiles of 28 immune cells within psoriatic immune microenvironment through single‐sample gene set enrichment analysis (ssGSEA) algorithm based on the eleven psoriasis related microarray datasets. Five immune‐related genes CXCL8, CXCL9, CCL18, RGS1, and SAMSN1 are associated with psoriasis, and establish a predictive ...
Tingjin Zheng, Rong Xu, Jianming Zhang, Xiujuan Wen, Hao Huang, Hongfeng Tang, Zhishan Zhang, Chong Zeng   +7 more
wiley   +1 more source

The Biological Significance of Calmodulin Binding to Lipids. [PDF]

Biology (Basel)
O'Day DH.
europepmc   +1 more source

Role of ZNF652 in Regulating Hepatocellular Carcinoma Cell Proliferation and Apoptosis via the circRHOT1/SLC38A6 Axis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Hepatocellular carcinoma (HCC) is a heterogeneous malignancy characterized by high mortality rates. This article presents a discussion of the role of ZNF652 in HCC cell proliferation and apoptosis, thereby identifying a new target for HCC treatment. The expression levels of ZNF652, circRHOT1, and SLC38A6 in HCC and healthy cells were analyzed.
Kang Chen, Fei‐Hu Sun, Chen Fan, Wei Ding, Hao‐Huan Tang, Lei Sun, Wei‐Tao Wang, Wei‐Dong Wang   +7 more
wiley   +1 more source

Rho/ROCK Signaling Pathway in Kidney Diseases: Mechanisms and Therapeutic Perspectives. [PDF]

Biomedicines
Xiong W, Miao D, Hou Z, Zhang X, Xiong Z.   +4 more
europepmc   +1 more source

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

Global conformation of the Rag GTPase heterodimer governs eukaryotic amino acid sensing. [PDF]

Proc Natl Acad Sci U S A
Doxsey DD, Shen K.
europepmc   +1 more source