Results 251 to 260 of about 322,041 (407)

Mechanotransduction in Shaping Immunity: Pathways, Crosstalk, and Pathophysiological Relevance

Advanced Science, EarlyView.
This review comprehensively summarizes the role of mechanotransduction in shaping immunity. It details how immune cells respond to biomechanical cues via mechanotransduction cascades and emphasizes the mechanical crosstalks within the immune microenvironment. The emerging significance of mechanoimmunology in both health and diseases is also highlighted.
Ruijiao Yan, Yuyu Li, Shuo Chen, Li Zhu, Chenchen Zhou, Jianwei Chen, Shujuan Zou, Xianglong Han   +7 more
wiley   +1 more source

Playing Multiple Parts: Unique Enzymatic and Structural Roles Orchestrated by SYNGAP1. [PDF]

Epilepsy Curr
Buchanan GF.
europepmc   +1 more source

GTPase activity of small GTP-binding proteins in HL-60 membranes is stimulated by arachidonic acid [PDF]

, 1993
Erzsébet Ligeti, Véronique Pizon, Alfred Wittinghofer, Peter Gierschik, Karl H. Jakobs   +4 more
openalex   +1 more source

ARL5B Drives Esophageal Squamous Cell Carcinoma Progression via ROCK1–SREBP1‐Mediated Lipid Metabolic Reprogramming

Advanced Science, EarlyView.
Esophageal squamous cell carcinoma urgently requires new therapeutic strategies. Adenosine diphosphate‐ribosylation factor‐like protein 5B (ARL5B) is identified as a novel oncogene that remodels fatty acid metabolism through the ras homologous‐associated coiled‐coil containing protein kinase 1 (ROCK1)–sterol regulatory element‐binding protein 1 (SREBP1)
Xinyue Ma, Yanfei Sun, Hongyuan Mao, Chenhan Huang, Zerun Li, Tianzi Wang, Dizhi Jiang, Xinyu Zhang, Zhenyu Yuan, Zhihui Zhang, Bo Cheng, Ruiqing Wang, Yufeng Cheng   +12 more
wiley   +1 more source

Comprehensive analysis of aberrant alternative splicing and RNA binding proteins associated with age-related sensorineural hearing loss. [PDF]

Sci Rep
Yu W, Qin Z, Liang X, Zhu X, Tan G, Ren B, Xiang Y, Zou C, Zhou X, Wang H, Deng A.   +10 more
europepmc   +1 more source

SpaBalance: Balanced Learning for Efficient Spatial Multi‐Omics Decoding

Advanced Science, EarlyView.
SpaBalance is a computational framework that harmonizes multi‐omics learning via gradient equilibrium and dual‐stream feature decomposition, achieving superior clustering accuracy, biological interpretability, and scalable integration of three or more spatial omics modalities.
Yingbo Cui, Yong Zhao, Canqun Yang, Tao Tang, Xiangke Liao, Hongyu Zhang, Huiying Zhao, Zheng Wang, Yuansong Zeng   +8 more
wiley   +1 more source

DNA aptamer Apt_ERA 2 targets ERA from Staphylococcus aureus and limits GTP hydrolysis. [PDF]

Sci Rep
Peñaranda K, Pereira N, Savva O, Petrelli D, Spurio R, Corrigan RM, Milon P.   +6 more
europepmc   +1 more source

Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease

Oncogene, 2014
D. R. Cook, K. Rossman, C. Der
semanticscholar   +1 more source

Introduction toSmall GTPases [PDF]

Small GTPases, 2010
Williams, Michael J., Rottner, Klemens
openaire   +4 more sources

Insect I‐Type Lysozymes Function as Antiviral Proteases by Forming Biomolecular Condensates

Advanced Science, EarlyView.
Upon rice viral infection, the insect vector activates the Toll–MyD88–Dorsal signaling cascade, inducing i‐type lysozyme (Lyz‐I1) expression. Lyz‐I1 functions as an antiviral protease through its conserved catalytic dyad Glu/Asp (E/D), mediating cleavage of viral proteins at specific Lys (K) residues.
Yu Du, Yuqing Xiao, Manman Hu, Jinhua Yang, You Li, Taiyun Wei   +5 more
wiley   +1 more source