Results 51 to 60 of about 61,842 (198)

Histone Deacetylase 6 (HDAC6) in Ciliopathies: Emerging Insights and Therapeutic Implications

Advanced Science, EarlyView.
HDAC6 regulates primary cilia, crucial for cellular signalling and environmental responses. Dysregulation of HDAC6 contributes to ciliopathies, affecting multiple organs. This review examines HDAC6's role in ciliogenesis, its interaction with signaling molecules, and its potential as a therapeutic target.
Zhiyi Wang, Xiaofan Zhu, Zhenzhou Huang, Kaidi Ren, Jie Ran, Yang Yang   +5 more
wiley   +1 more source

Prodrugs of the Archetypal Dynamin Inhibitor Bis‐T‐22

ChemMedChem, Volume 17, Issue 24, December 16, 2022., 2022
The Bis‐T series of compounds comprise some of the most potent inhibitors of dynamin GTPase activity yet reported, such as Bis‐T‐22 (2). The catechol moieties are believed to limit cell permeability, rendering these compounds largely inactive in cells.
Luke R. Odell, Mark J Robertson, Kelly A Young, Andrew B. McGeachie, Annie Quan, Phillip J. Robinson, Adam McCluskey   +6 more
wiley   +1 more source

A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex

Journal of Cell Biology, 1996
Ran is a nuclear Ras-like GTPase that is required for the bidirectional transport of proteins and ribnucleoproteins across the nuclear pore complex (NPC). A key regulator of the Ran GTP/GDP cycle is the 70-kD Ran-GTPase-activating protein RanGAP1.
M. Matunis, E. Coutavas, G. Blobel
semanticscholar   +1 more source

Accumulation of Damaging Lipids in the Arf1‐Ablated Neurons Promotes Neurodegeneration through Releasing mtDNA and Activating Inflammatory Pathways in Microglia

Advanced Science, EarlyView.
Arf1 defects activate the AKT‐mTORC1‐SREBP1‐FASN pathway to increase lipid synthesis and disrupt ER‐mitochondrial‐lysosomal homeostasis in neurons. Impaired mitochondria secrete damaged mtDNA via mitochondria‐derived extracellular vesicles, which is phagocytosed by the microglia and activated inflammation signaling.
Xu Li, Shuhan Jin, Danke Wang, Ying Wu, Xiaoyu Tang, Yufan Liu, Tiange Yao, Shoufa Han, Lin Sun, Yuetong Wang, Steven X. Hou   +10 more
wiley   +1 more source

A Homogenous Bioluminescent System for Measuring GTPase, GTPase Activating Protein, and Guanine Nucleotide Exchange Factor Activities

Assay and drug development technologies, 2015
GTPases play a major role in various cellular functions such as cell signaling, cell proliferation, cell differentiation, cytoskeleton modulation, and cell motility.
Subhanjan Mondal, K. Hsiao, S. Goueli
semanticscholar   +1 more source

Targeting miRNA‐1a and miRNA‐15b: A Novel Combinatorial Strategy to Drive Adult Cardiac Regeneration

Advanced Science, EarlyView.
The article explores a novel therapeutic strategy for cardiac regeneration by targeting miRNA‐1a and miRNA‐15b. Combinatorial inhibition of miR‐1a and miR‐15b enhances cardiomyocyte proliferation, improves heart function, and reduces fibrosis in myocardial infarction models.
Ting Yuan, Meiqian Wu, Chaonan Zhu, Hao Yu, Minh Duc Pham, Katharina Bottermann, Yijie Mao, Yue Wang, Mathias Langner, Mirko Peitzsch, Arka Provo Das, Silke Kauferstein, Jonathan Ward, Peter Mirtschink, Andreas Michael Zeiher, Stefanie Dimmeler, Jaya Krishnan   +16 more
wiley   +1 more source

Pupylation‐Based Proximity Labeling Unravels a Comprehensive Protein and Phosphoprotein Interactome of the Arabidopsis TOR Complex

Advanced Science, EarlyView.
The target of rapamycin (TOR) complex is a central plant growth regulator. Here, the protein–protein interactions underlying its various functions are mapped by pupylation‐based proximity‐labeling in Arabidopsis, using TOR complex subunits LST8‐1 and RAPTOR1, alongside TOR inhibitor FK506‐binding protein, as baits.
Shuai Zheng, Leonard Blaschek, Delphine Pottier, Luuk Robin Hoegen Dijkhof, Beyza Özmen, Peng Ken Lim, Qiao Wen Tan, Marek Mutwil, Alexander Sebastian Hauser, Staffan Persson   +9 more
wiley   +1 more source

Structure and evolution of neuronal wiring receptors and ligands

Developmental Dynamics, Volume 252, Issue 1, Page 27-60, January 2023., 2023
Abstract One of the fundamental properties of a neuronal circuit is the map of its connections. The cellular and developmental processes that allow for the growth of axons and dendrites, selection of synaptic targets, and formation of functional synapses use neuronal surface receptors and their interactions with other surface receptors, secreted ...
Elena Cortés, Joseph S. Pak, Engin Özkan   +2 more
wiley   +1 more source

Syntaxin 17 Translocation Mediated Mitophagy Switching Drives Hyperglycemia‐Induced Vascular Injury

Advanced Science, EarlyView.
Mitophagy switching drives high‐glucose‐induced vascular endothelial injury. Short‐term high‐glucose exposure upregulates Fis1 expression and enhances Fis1‐TBC1D15 interaction, activating Parkin‐mediated mitophagy. Long‐term high‐glucose exposure reduces Fis1 expression, inhibiting Parkin‐mediated mitophagy and triggering mitophagy switching from ...
Anqi Luo, Rui Wang, Jingwen Gong, Shuting Wang, Chuan Yun, Zongcun Chen, Yanan Jiang, Xiaoquan Liu, Haofu Dai, Haochen Liu, Yunsi Zheng   +10 more
wiley   +1 more source

Insulin-stimulated Phosphorylation of a Rab GTPase-activating Protein Regulates GLUT4 Translocation*

Journal of Biological Chemistry, 2003
Insulin stimulates the rapid translocation of intracellular glucose transporters of the GLUT4 isotype to the plasma membrane in fat and muscle cells.
H. Sano, S. Kane, Eiko Sano, C. Mîinea, J. Asara, William Arbuthnot Sir Lane, C. W. Garner, G. Lienhard   +7 more
semanticscholar   +1 more source