Results 141 to 150 of about 103,749 (273)

Guanidinylated bioresponsive poly(amido amine)s designed for intranuclear gene delivery

International Journal of Nanomedicine, 2016
Jiankun Yu,1 Jinmin Zhang,1 Haonan Xing,1 Zhen Yang,1 Cuifang Cai,1 Conglu Zhang,1 Xiaoyun Zhao,1 Minjie Wei,2 Li Yang,1 Pingtian Ding1 1School of Pharmacy, Shenyang Pharmaceutical University, 2School of Pharmacy, China Medical University, Shenyang ...
Yu J, Zhang J, Xing H, Yang Z, Cai C, Zhang C, Zhao X, Wei M, Yang L, Ding P   +9 more
doaj  

Exercise‐induced miR‐126 expression improves vascular health in prediabetes: A randomized controlled trial

Experimental Physiology, EarlyView.
Abstract In this study, we investigated whether a structured aerobic exercise programme could enhance microRNA‐126 (miR‐126) expression and improve subclinical atherosclerosis markers [carotid intima–media thickness (CIMT) and ankle–brachial index (ABI)] in individuals with prediabetes.
Elif Yildirim Ayaz, Sadrettin Pençe, Sibel Kuraş, Emine Şeyma Denli Yalvaç, Banu Mesci, Özden Ezgi Üner, Fatoş Nimet Kaya, Berna Dincer, Ferruh Kemal Işman, Aytekin Oğuz   +9 more
wiley   +1 more source

Differential effect of lead and cadmium on mitochondrial function and NLRP3 inflammasome activation in human trophoblast

The Journal of Physiology, EarlyView.
Abstract figure legend The human placenta not only detects the presence of Pb and Cd but also carries hypoxia and inflammatory risks, which are associated with pregnancy complications. To understand the impact of these factors on the placental trophoblast, we evaluated the effect of Pb and Cd on mitochondrial function and the NLRP3 inflammasome in ...
Yifeng Dai, Xijin Xu, Xia Huo, Joost H. N. Schuitemaker, Marijke M. Faas   +4 more
wiley   +1 more source

Electronic Smoking Devices Among University Students: Usage Patterns and Chemical Composition of Inhaled Substances

Analytical Science Advances, Volume 7, Issue 1, June 2026.
ABSTRACT This study investigated the prevalence of electronic smoking device (ESD) use and its associated behavioural and chemical risks among university students in Bahia, Brazil. A cross‐sectional survey was conducted with 355 students from public and private institutions through an online questionnaire between April and May 2023. Among participants,
Eduard F. Valenzuela, Raffael Silva Santos Almeida, Ivana Ferreira Simões, Aline Gonçalves Miranda, Magno Oliveira Ramos, Roberto Rodrigues Bandeira Tosta Maciel, Fernanda Warken Rosa, Aníbal de Freitas Santos Júnior   +7 more
wiley   +1 more source

A New Guanidine-Core Small-Molecule Compound as a Potential Antimicrobial Agent against Resistant Bacterial Strains

Antibiotics
The guanidine core has been one of the most studied functional groups in medicinal chemistry, and guanylation reactions are powerful tools for synthesizing this kind of compound.
Noelia Morata-Moreno, Ramón Pérez-Tanoira, Almudena del Campo-Balguerias, Fernando Carrillo-Hermosilla, Marcos Hernando-Gozalo, Carlos Rescalvo-Casas, Ana V. Ocana, Pedro Segui, Carlos Alonso-Moreno, Francisco C. Pérez-Martínez, Milagros Molina-Alarcón   +10 more
doaj   +1 more source

Systemic Consequences of Chronic Ethanol Intake: From Microbiome Shifts to Metabolic Impairment

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Chronic ethanol intake disrupts whole‐body homeostasis by reducing energy intake and body mass, impairing physical function, and reshaping the gut microbiome. Microbiota shifts and depletion of short‐chain fatty acids increase gut permeability and drive hepatic inflammation, dyslipidemia, and glucose intolerance.
Muni Swamy Ganjayi, Thomas A. Krauss, Gage E. Demster, Sehyung Park, Garrett B. Anspach, Sarah R. Anthony, Shaohua Wang, Michael Tranter, Robert N. Helsley, Cory W. Baumann   +9 more
wiley   +1 more source

Addressing Current Challenges in Hydrogel Wound Dressing Strategies for Chronic Wound Management: Advances and Future Directions

Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 114, Issue 4, April 2026.
ABSTRACT Given the market for chronic wound care, where wound dressings are the key product, it should go without saying that providing satisfactory wound dressings is critical. A wide variety of wound dressings have been developed. Hydrogel has drawn attention as a potential wound dressing for chronic wounds. Hydrogel may absorb large amounts of water
Gianna Fadhilah, Chen‐Ying Su, Hsu‐Wei Fang   +2 more
wiley   +1 more source

Non‐Viral Cytokine‐Inducible SH2 Containing Protein Locus‐Specific Integrated Fibroblast Activation Protein Alpha‐Targeting Chimeric Antigen Receptor T Cells Achieve Potent Antitumor Efficacy in Glioblastoma

MedComm, Volume 7, Issue 4, April 2026.
FAPα is a dual target on glioblastoma cells and perivascular cells. Using a high‐affinity anti‐FAPα nanobody, we generated CISH‐KO FAPα‐CAR‐T cells via non‐viral CRISPR–Cas9 integration. These cells demonstrated enhanced proliferation and superior antitumor efficacy in patient‐derived organoids and orthotopic mouse models compared to conventional CAR‐T
Xin Dong, Yao Sun, Yuetong Guo, Jiao Wang, Fei Wang, Ziming Wang, Ruizhen Li, Fei Xie, Tingting Tan, Baijie Cheng, Ronghan Huang, Shu Zhang, Xiaotong Lin, Zhaoze Guo, Hubing Wu, Hao Wu, Xubiao Zhang, Guozhu Xie   +17 more
wiley   +1 more source

Denoising Low-Power CEST Imaging Using a Deep Learning Approach With a Dual-Power Feature Preparation Strategy. [PDF]

Magn Reson Med
ABSTRACT Purpose: Low‐power (LP) chemical exchange saturation transfer (CEST) Z‐spectra have significantly reduced confounding effects and enhanced peak resolvability, thereby improving the observation and quantification of various CEST effects. However, LP Z‐spectra suffer greatly from reduced contrast‐to‐noise ratio (CNR).
Kurmi Y, Viswanathan M, Yin L, Chen Y, Jiang X, Xu J, Zu Z.   +6 more
europepmc   +2 more sources

High molecular thyrotrophin ("big"-TSH) from human pituitaries : Preparation and partial characterization [PDF]

, 1977
Erhardt, F., Scriba, Peter Christian
core   +1 more source