Results 151 to 160 of about 103,749 (273)

Small heat shock proteins HspB1 and HspB5 differentially alter the condensation and aggregation of the TDP‐43 low‐complexity domain

Protein Science, Volume 35, Issue 4, April 2026.
Abstract TAR DNA‐binding protein 43 (TDP‐43) is a nucleic acid‐binding protein that regulates processes of mRNA metabolism, during which it undergoes condensation mediated by its C‐terminal low‐complexity domain (TDP‐43LCD). TDP‐43 aggregation and condensation are associated with neurodegenerative disease.
Thomas B. Walker, Joshua W. Trowbridge, Shannon McMahon, Nicholas R. Marzano, Lauren Rice, Justin J. Yerbury, Heath Ecroyd, Luke McAlary   +7 more
wiley   +1 more source

Targeting Inflammatory and Oxidative Pathways in Idiopathic Pulmonary Fibrosis: Synergistic Effects of Quercetin and Pirfenidone in Modulating Nrf2/PPAR‐γ and TLR‐4/NF‐κB Pathways

Pharmacology Research &Perspectives, Volume 14, Issue 2, April 2026.
Pirfenidone (Pirf) and Quercetin (Quer) both reduced inflammation, oxidative stress, and fibrosis in a bleomycin‐induced pulmonary fibrosis model, with Quer showing a stronger effect than Pirf. The combination of Pirf and Quer provided enhanced anti‐fibrotic and anti‐inflammatory benefits, suggesting potential for improved therapeutic strategies in ...
Hanaa Wanas, Amira Karam Khalifa, Hossein M. Elbadawy, Amany E. Hamoud, Mohannad A. Almikhlafi, Emad Ali Albadawi, Hadel Mahroos Alghabban, Wejdan Hussain Owaydhah, Amr M. Galal   +8 more
wiley   +1 more source

Development of a C5‐Azidoacetamide‐Modified 4‐Amino‐2,3‐Difluorosialic Acid Activity‐Based Probe for Labeling of Influenza A Neuraminidases

ChemBioChem, Volume 27, Issue 6, 27 March 2026.
We report DFSA5Az/DFSA5bio, C5‐azidoacetamide 4‐amino‐2,3‐difluorosialic acid activity‐based probes that trap influenza A viral (IAV) neuraminidases (NA) via a stabilized covalent Tyr‐sialosyl intermediate with hour‐scale reactivation. A bioorthogonal azide enables CuAAC (or one‐step biotin) tagging for activity‐dependent Western‐blot detection at ...
Lemeng Chao, Erianna I. Alvarado‐Melendez, Katherine Marougka, Xuesheng Wu, Cornelis A. M. de Haan, Karin Strijbis, Tom Wennekes   +6 more
wiley   +1 more source

Synthesis and Biological Profile of Substituted Pyrrolidinyl Carboxamides for Acyl‐ACP Thioesterase Inhibition

European Journal of Organic Chemistry, Volume 29, Issue 12, 23 March 2026.
The work outlined herein covers a series of novel herbicidal lead structures that possess a pyrrolidinyl pyrazole carboxamide scaffold as a key structural feature, carrying further substituted benzyl side chains. Based on scaffold hopping approaches from known fungicidal and herbicidal compounds and utilizing an optimized synthetic approach, a broader ...
Elisabeth Asmus, Martin Annau, Neanne Alnafta, David M. Barber, Guido Bojack, Birgit Bollenbach‐Wahl, Ralf Braun, Ronald W. Brown, Luke R. Churchman, Christine Dörnbrack, Andrew Earl, Tyler Fahrenhorst‐Jones, Jörg Freigang, Claudia Hartfiel, Ines Heinemann, Arnim Köhn, Bernd Laber, Michael C. McLeod, Catherine S. Meister, Gudrun Lange, Luka Posa, Shaun Rees, Dirk Schmutzler, Anna M. Reingruber, Jens Frackenpohl   +24 more
wiley   +1 more source

Bioinspired, Guanidinium, and Indole Modified Poly(glycidyl ether)s as Highly Efficient Vectors for Polyplex-Mediated Gene Delivery. [PDF]

Macromol Rapid Commun
Guanidinium‐ and indole‐functionalized poly(glycidyl ether)s were developed as non‐viral gene delivery vectors with tunable hydrophilic–hydrophobic balance. All polymers formed stable DNA polyplexes, while moderate indole content yielded the highest transfection efficiency at low N/P ratios.
Kötzsche M, Dzierza A, Sölter L, Egger J, Cornelis K, Stihl A, Schacher FH, Fischer D, Peneva K.   +8 more
europepmc   +2 more sources

Structural and Functional Validation of Pseudomonas Savastanoi Ethylene Forming Enzymes Reveals Flexibility in 2‐Oxoglutarate Binding Mode and Conformation

ChemBioChem, Volume 27, Issue 5, 13 March 2026.
Studies with naturally occuring variants of the Pseudomonas savastanoi ethylene‐forming enzyme (PsEFE) inform on the effect of residues on turnover and product ratio. Crystallographic studies imply a potential for metal ion sensing. Pseudomonas savastanoi pv.
Yihong Sun, Siddhant Dhingra, Mark D. Allen, Ethan S. Z. Cheng, Zhihong Zhang, Christopher J. Schofield, Lennart Brewitz   +6 more
wiley   +1 more source

Targeting Expanded CUG and CTG Repeats as a Therapeutic Approach for Myotonic Dystrophy Type 1 (DM1)

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
DM1 is an RNA gain‐of‐function disease caused by CTG repeat expansion, producing toxic r(CUG)exp RNA that sequesters MBNL1 and impairs splicing. This review covers the field of CUG and CTG ligands identified or rationally designed as DM1 drug candidates, highlighting their molecular design, RNA‐ or DNA‐binding modes, in vitro affinities and ...
Camille Richagneux, Anton Granzhan
wiley   +1 more source

Synthesis of guanidine from ammonium thiocyanate in solid state

Journal of the Brazilian Chemical Society, 2004
Guanidine is an important substance for modern living beings as well as for the prebiotic chemistry. We studied the reaction between ammonium and thiocyanate species in solid state with different substances (river sand, kaolin, transition metals, salts ...
Zaia Dimas A. M., Santana Henrique de, Toppan Rodrigo, Zaia Cássia T. B. V.   +3 more
doaj  

Preservation of cell‐free RNA in percutaneous core‐needle biopsy specimens' supernatants from non‐small cell lung cancer improves genomic testing performance

The Journal of Pathology: Clinical Research, Volume 12, Issue 2, March 2026.
Abstract This prospective single‐center study aimed to investigate whether preserving cell‐free ribonucleic acid (cfRNA) in specimens' supernatants (SS) obtained from percutaneous core‐needle biopsy (CNB) of non‐small cell lung cancer (NSCLC) can improve the performance of genomic testing.
Sheng Xu, Yi‐Dan Ma, Zhi‐Xin Bie, Jing‐Yu Huang, Yuan‐Ming Li, Zheng Wang, Xiao‐Guang Li   +6 more
wiley   +1 more source

Performance Constraints of All‐Perovskite Tandem Solar Cells in Low‐Intensity, Low‐Temperature Environments

Advanced Materials, Volume 38, Issue 15, 12 March 2026.
All‐perovskite tandem solar cells are evaluated under low‐intensity and low‐temperature (LILT) conditions relevant to space environments. Distinct loss regimes emerge, where weaker entropic mixing causes halide segragation below ≈240 K going along with a strong current imbalance, while poor electron transport in C60 dominates.
Sercan Ozen, Etienne Beier, Francisco Peña‐Camargo, Jarla Thiesbrummel, Gianluca Boccarella, Paria Forozi Sowmeeh, Martin Stolterfoht, Dieter Neher, Kai Oliver Brinkmann, Thomas Riedl, Felix Lang   +10 more
wiley   +1 more source