Results 51 to 60 of about 55,046 (163)

Differential effect of lead and cadmium on mitochondrial function and NLRP3 inflammasome activation in human trophoblast

The Journal of Physiology, EarlyView.
Abstract figure legend The human placenta not only detects the presence of Pb and Cd but also carries hypoxia and inflammatory risks, which are associated with pregnancy complications. To understand the impact of these factors on the placental trophoblast, we evaluated the effect of Pb and Cd on mitochondrial function and the NLRP3 inflammasome in ...
Yifeng Dai, Xijin Xu, Xia Huo, Joost H. N. Schuitemaker, Marijke M. Faas   +4 more
wiley   +1 more source

Electronic Smoking Devices Among University Students: Usage Patterns and Chemical Composition of Inhaled Substances

Analytical Science Advances, Volume 7, Issue 1, June 2026.
ABSTRACT This study investigated the prevalence of electronic smoking device (ESD) use and its associated behavioural and chemical risks among university students in Bahia, Brazil. A cross‐sectional survey was conducted with 355 students from public and private institutions through an online questionnaire between April and May 2023. Among participants,
Eduard F. Valenzuela, Raffael Silva Santos Almeida, Ivana Ferreira Simões, Aline Gonçalves Miranda, Magno Oliveira Ramos, Roberto Rodrigues Bandeira Tosta Maciel, Fernanda Warken Rosa, Aníbal de Freitas Santos Júnior   +7 more
wiley   +1 more source

Targeting Inflammatory and Oxidative Pathways in Idiopathic Pulmonary Fibrosis: Synergistic Effects of Quercetin and Pirfenidone in Modulating Nrf2/PPAR‐γ and TLR‐4/NF‐κB Pathways

Pharmacology Research &Perspectives, Volume 14, Issue 2, April 2026.
Pirfenidone (Pirf) and Quercetin (Quer) both reduced inflammation, oxidative stress, and fibrosis in a bleomycin‐induced pulmonary fibrosis model, with Quer showing a stronger effect than Pirf. The combination of Pirf and Quer provided enhanced anti‐fibrotic and anti‐inflammatory benefits, suggesting potential for improved therapeutic strategies in ...
Hanaa Wanas, Amira Karam Khalifa, Hossein M. Elbadawy, Amany E. Hamoud, Mohannad A. Almikhlafi, Emad Ali Albadawi, Hadel Mahroos Alghabban, Wejdan Hussain Owaydhah, Amr M. Galal   +8 more
wiley   +1 more source

Structural and Functional Validation of Pseudomonas Savastanoi Ethylene Forming Enzymes Reveals Flexibility in 2‐Oxoglutarate Binding Mode and Conformation

ChemBioChem, Volume 27, Issue 5, 13 March 2026.
Studies with naturally occuring variants of the Pseudomonas savastanoi ethylene‐forming enzyme (PsEFE) inform on the effect of residues on turnover and product ratio. Crystallographic studies imply a potential for metal ion sensing. Pseudomonas savastanoi pv.
Yihong Sun, Siddhant Dhingra, Mark D. Allen, Ethan S. Z. Cheng, Zhihong Zhang, Christopher J. Schofield, Lennart Brewitz   +6 more
wiley   +1 more source

Targeting Expanded CUG and CTG Repeats as a Therapeutic Approach for Myotonic Dystrophy Type 1 (DM1)

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
DM1 is an RNA gain‐of‐function disease caused by CTG repeat expansion, producing toxic r(CUG)exp RNA that sequesters MBNL1 and impairs splicing. This review covers the field of CUG and CTG ligands identified or rationally designed as DM1 drug candidates, highlighting their molecular design, RNA‐ or DNA‐binding modes, in vitro affinities and ...
Camille Richagneux, Anton Granzhan
wiley   +1 more source

Preservation of cell‐free RNA in percutaneous core‐needle biopsy specimens' supernatants from non‐small cell lung cancer improves genomic testing performance

The Journal of Pathology: Clinical Research, Volume 12, Issue 2, March 2026.
Abstract This prospective single‐center study aimed to investigate whether preserving cell‐free ribonucleic acid (cfRNA) in specimens' supernatants (SS) obtained from percutaneous core‐needle biopsy (CNB) of non‐small cell lung cancer (NSCLC) can improve the performance of genomic testing.
Sheng Xu, Yi‐Dan Ma, Zhi‐Xin Bie, Jing‐Yu Huang, Yuan‐Ming Li, Zheng Wang, Xiao‐Guang Li   +6 more
wiley   +1 more source

IL‐4/STAT6‐signaling Influences Local Inflammation and Regeneration Processes During Acute Pancreatitis and Promotes Fibrosis by a Direct Activation of Pancreatic Fibroblasts During Chronic Pancreatitis

Advanced Science, Volume 13, Issue 14, 9 March 2026.
IL‐4/IL‐13/STAT6 signaling plays a crucial for the suppression of pro‐inflammation during acute pancreatitis and supports acinar cell regeneration but has only minor impact on fibrogenesis during chronic form of the disease. IL‐4/IL‐13 induce the expression of certain collagens directly in pancreatic fibroblasts via STAT6 activation, whereas ...
Hager ElSheikh, Annika Salvers, Judith Piesker, Shenja Buchholz, Rabea Lange, Sabine Ameling, Leif Steil, Elke Hammer, Georg Homuth, Uwe Völker, Barbara M. Bröker, Frank U. Weiss, Matthias Sendler, Juliane Glaubitz   +13 more
wiley   +1 more source

Expanding the Chemical Space of Cyclic Polyphthalaldehyde via Post‐Functionalization

Advanced Science, Volume 13, Issue 13, 3 March 2026.
In this work, we developed a post‐functionalization approach to achieve water‐soluble cyclic polyphthalaldehyde (cPPA) polymers via click chemistry. ABSTRACT Cyclic polyphthalaldehydes (cPPAs) are hydrophobic cyclic polymers with stimuli‐responsive depolymerization property. The introduction of hydrophilic functionalities to cPPAs is challenging due to
Liting He, Haiyan Zhou, Qiushi Chen, Xing Guo, Han Liu, Xuechen Li   +5 more
wiley   +1 more source

Comparison of Pre‐ and Postoperative Gut Microbiota Diversity in Patients With Rectal Cancer Undergoing Stoma Creation and Closure

Annals of Gastroenterological Surgery, Volume 10, Issue 2, Page 492-501, March 2026.
We investigated the impact of temporary stoma creation and closure on gut microbiota diversity in rectal cancer patients. 16S rRNA sequencing revealed that microbial diversity significantly decreased postoperatively in the stoma group but remained stable in non‐stoma patients.
Yusuke Suzuki, Wataru Osumi, Kohei Taniguchi, Nahoko Kato‐Kogoe, Shoichi Sakaguchi, Shota Nakamura, Yoshiro Imai, Takashi Nakano, Takaaki Ueno, Sang‐Woong Lee   +9 more
wiley   +1 more source

Photo‐Catalyzed Labeling of Amyloid Deposits in Human Tissue to Proteotype Amyloidosis Diseases

Aggregate, Volume 7, Issue 3, March 2026.
Amyloid‐ID, a ThT‐like photocatalytic probe, enables proteotyping of amyloid deposits by ROS‐mediated protein labeling. Applied to patient biopsies, amyloid‐ID identifies potential fibrinogen‐derived amyloid in laryngeal amyloidosis, revealing a mechanically sensitive fibrillation mechanism linked to vocal cord friction.
Huan Feng, Fangliang Guo, Yan Wang, Meng You, Qiuxuan Xia, Wang Wan, Di Shen, Kaini Shen, Xin Zhang, Wei Li, Yu Liu   +10 more
wiley   +1 more source