Results 81 to 90 of about 46,713 (191)
Chemistry – A European Journal, EarlyView.The late‐stage intermolecular O‐acylation of the threonine (Thr) side chain was accomplished by reacting thiol‐incorporated Thr with a peptide thioester in open air. The thioester, which contained the volatile trifluoroethanethiol, facilitated the formation of S,O‐diacyl peptides.
Daiki Sato +4 more
wiley +1 more source
Strategy‐Level Prodrug Synthesis
Chemistry – A European Journal, EarlyView.Prodrug approaches can be expanded by increasing options for controlling site‐selective functionalization, boosting the range of linking groups, and enhancing the chemoselectivity of reactive group incorporation. This Concept describes strategy‐level prodrug synthesis, whereby these issues are addressed at an early stage of a sequence.
Paul J. Geaneotes, Paul E. Floreancig
wiley +1 more source
Chemistry – A European Journal, EarlyView.A new class of catalytically highly efficient bifunctional imidazopyridine (ImPy)‐based gold(I) complexes was synthesized. The ligands are based on tetrahedral C‐stereogenic centers derived from straightforward chiral pool synthesis. Unprecedented cycloisomerization products of 1,6‐enynols were observed in excellent enantioselectivity up to 99:1 er ...
Lukas Enders +4 more
wiley +1 more source
ChemMedChem, EarlyView.The serine capsid protease (CP) catalyzes a crucial process of the alphaviral replication cycle; therefore, it constitutes an interesting therapy target. Herein, the O'nyong‐nyong virus CP profile activity with a specific fluorogenic substrate is analyzed and examines the inhibitory activity of a new series of phosphonic analogs of tryptophan and ...
Karolina Torzyk‐Jurowska +5 more
wiley +1 more source
Chemistry–Methods, EarlyView.This review briefly highlights the construction of charge‐assisted hydrogen‐bonded organic frameworks using a variety of organic acids and organic bases, which feature different hydrogen‐bonding motifs, along with their applications, including negative linear compressibility, proton conduction, atmospheric water harvesting, gas adsorption and ...
Xian‐Xian Xiao +5 more
wiley +1 more source
The Prefusogenic Intermediate of HIV-1 gp41 Contains Exposed C-peptide Regions [PDF]
, 2003 The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein is composed of a complex between the surface subunit gp120, which binds to cellular receptors, and the transmembrane subunit gp41.
Chan, David C., Koshiba, Takumi
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Reactions of 1,4‐Diborinine Derivatives with CO2
ChemPhysChem, EarlyView.The reaction of CO2 with seven molecules featuring a 1,4‐diborinine central ring is studied by means of density functional theory calculations. The selected systems present five‐ and six‐membered aza rings surrounding 1,4‐diborinine. The computed reactivity trends and origin of regioselectivity are quantitatively analyzed with the activation strain ...
Maxime Ferrer +3 more
wiley +1 more source
Organocatalyzed Diels‐Alder Reactions: Unexplored Hydrogen Bond Donor Catalysts
ChemPlusChem, EarlyView.Quantum chemical activation strain analyses show that urea‐derived hydrogen‐bond organocatalysts, including unconventional alternatives to the C=O group (e. g., C=C and C=Si), lower the Diels‐Alder reaction barrier between butadiene and acrolein by Pauli lowering catalysis.
Eveline H. Tiekink +3 more
wiley +1 more source
Mechanochemical Activation of NaHCO3: A Solid CO2 Surrogate in Carboxylation Reactions
ChemSusChem, EarlyView.This study presents sodium bicarbonate (NaHCO3) as a safe, solid source of CO2 for mechanochemical carboxylation reactions. Mechanochemical methods for synthesizing cyclic carbamates and organic carbonates from NaHCO3 are developed. This approach holds significant potential for pharmaceutical applications, highlighting solvent‐minimized synthesis and ...
Francesco Mele +11 more
wiley +1 more source