Results 131 to 140 of about 6,480 (239)

Synthetic polymer nanocarrier enhances dsRNA stability but not RNAi efficacy in Brassicogethes aeneus

Pest Management Science, EarlyView.
Experimental setup for dsRNA feeding in Brassicogethes aeneus to evaluate the effect of a synthetic polymer nanocarrier on RNAi efficiency. The experiment assessed whether the nanocarrier enhances RNAi after oral dsRNA delivery. (a) Stability of dsRNA–nanocarrier complexes was tested in simulated gut conditions. (b) Gene expression of αCOP and dre4 was
Triin Kallavus, Liina Soonvald, Iris Callewaert, Ana Isabel Silva, Ericmar Ávila Dos Santos, Silva Vilumets, Riina Kaasik, Sven Vereecken, Lenny Van Daele, Peter Dubruel, Jonathan Willow, Clauvis Nji Tizi Taning, Kristof De Schutter, Eve Veromann   +13 more
wiley   +1 more source

UV mutagenesis‐enhanced Streptomyces nogalater produces a novel streptothricin‐like compound with strong activity against cabbage soft rot

Pest Management Science, EarlyView.
UV mutagenesis of Streptomyces sp. KRA0514‐6 yielded HL‐3, a novel streptothricin‐like compound (C17H29N7O8) with N‐methylglycine replacing β‐lysine, achieving 100% cabbage soft rot control at >1 ppm concentration. Abstract BACKGROUND A total of 1000 soil‐derived actinomycetes were isolated and screened for antibacterial activity against Pectobacterium
Young Sook Kim, Mirjalol Umurzokov, Hae Young Kim, Chun‐Zhi Jin, Eun Ae Kim, Kwang Min Cho   +5 more
wiley   +1 more source

Exploring the Fragmentation of Sodiated Species Involving Covalent‐Bond Cleavages for Metabolite Characterization

Rapid Communications in Mass Spectrometry, EarlyView.
ABSTRACT Rationale Electrospray (ESI), the most popular desorption/ionization technique used in mass spectrometry‐based metabolomics, generates both protonated and deprotonated molecules, as well as adduct ions, sodium being the most frequent monoatomic cation entering their composition.
Annelaure Damont, Ekaterina Darii, Chenqin Cao, Anaïs Legrand, Alain Perret, Sylvain Dechaumet, Amina S. Woods, Christophe Junot, Jean‐Claude Tabet, François Fenaille   +9 more
wiley   +1 more source

Peptide‐based antibacterial nanoplatforms: Design principles, stimuli‐regulated behaviors, and applications

Responsive Materials, EarlyView.
Peptide‐based antibacterial nanoplatforms, encompassing self‐assembled peptides and peptide‐engineered inorganic, polymeric, and lipid nanocarriers, are systematically reviewed. The article highlights design principles and stimuli‐responsive regulation for improving peptide stability, delivery efficiency, and antibacterial performance.
Peng Tan, Chenlong Zhou, Shuaikang Yang, Zhenduo Chen, Guanghui Zhao, Qi Tang, Haoyu Yan, Feng Li, Xi Ma   +8 more
wiley   +1 more source

Symmetry‐Guided Optical Control of Dynamic 1D Protein Self‐Assembly and Precise In Vitro Initiation of Biomolecular Condensation

Small, EarlyView.
A photoreversible 1D protein assembly has been developed by utilizing symmetry matching between StrepTactin and photoswitchable Dronpa145N. The light‐induced modulation of oligomerization allows for precise control over protein connectivity and valency.
Jangwon Bae, Yongwon Jung
wiley   +1 more source

Oppositely Charged Homopolypeptides Form Ordered Helix Assemblies With Hierarchical Structure

Small, EarlyView.
Hexagaonal and square assembly of polyarginine alfa‐helices formed in highly ordered polyarginine/polyaspartic acid complexes. The helices exhibit additional periodic staggering along their helical axis. ABSTRACT Oppositely charged polyelectrolytes are known to form polyelectrolyte complexes.
Ekaterina Buvalaia, Martin Dulle, Benoit David, Karoline Rengel, Michael Ohl, Beate Förster, Margarita Kruteva, Henrike Heise, Ralf Biehl, Holger Gohlke, Stephan Förster   +10 more
wiley   +1 more source

Nature‐Inspired Histidine and Guanidine Modification of Magnetic Nanoparticles for Urinary DNA Liquid Biopsy

Small Methods, EarlyView.
Nature‐inspired bi‐functionalized magnetic nanoparticles are engineered for the rapid, non‐invasive extraction of cell‐free DNA from unprocessed urine for liquid biopsy. These cationic particles leverage electrostatic interactions to outperform conventional kits, enhancing the recovery of short DNA fragments while maintaining DNA integrity.
Dina Haddad, Ishtiaq Ahmed, Manthos Pitoulias, Richard Mair, Ljiljana Fruk   +4 more
wiley   +1 more source

Modular Synthesis of α‐Quaternary Pyrrolines by Pyridoxal‐Catalyzed Sequential Reactions With Precise Chirality Relay

Transformative Chemistry, EarlyView.
Direct asymmetric α‐C conjugate addition of aminoacetonitrile enabled by carbonyl/iminium double activation, together with subsequent electrophilic functionalization, offers a one‐pot, two‐step modular strategy for synthesizing chiral α‐quaternary pyrrolines with precise chirality relay and high structural diversity.
Xingdie Yang, Pengwei Ji, Liang Liu, Tongyin Chen, Siqi Liu, Wen‐Wen Chen, Baoguo Zhao   +6 more
wiley   +1 more source

Derives d'acyl-guanidines modulateurs de la voie de signalisation des proteines hedgehog

, 2014
La présente invention est relative à des dérivés d'acyl-guanidines modulateurs de la voie de signalisation des protéines Hedgehog utilisés à titre de médicaments, notamment pour le traitement de pathologies impliquant un dysfonctionnement ...
Roudaut Hermine, Faure Hélène, Traiffort Elisabeth, Mann André, Schoenfelder Angèle, MANETTI, FABRIZIO, TADDEI, MAURIZIO, Solinas Antonio, Ruat Martial   +8 more
core   +1 more source

The synthesis of di(hydroxyalkyl) substituted bicyclic guanidines

, 1997
The synthesis of the enantiomerically pure bicyclic guanidines 3a and 3b is described. The convergent strategy is based on methodology developed by Schmidtchen.
Munster, I, Madder, Annemieke, De Clercq, Pierre, Rolle, U.   +3 more
core