Results 141 to 150 of about 6,480 (239)

Peptide‐directed nanovehicles enabling tumor‐selective ROS amplification and antitumor immunity

VIEW, EarlyView.
Cancer cells are vulnerable to oxidative stress, yet exploit immune tolerance to escape destruction. In contrast, their metabolic profile is markedly altered to support rapid proliferation, accompanied by elevated production of reactive oxygen species (ROS).
Manuela Calin, Galyna Bila, Ileana Manduteanu, Rostyslav Bilyy   +3 more
wiley   +1 more source

Polyaniline as a dual flame retardant and electrostatic dissipative additive in polyethylene nanocomposites

Journal of Vinyl and Additive Technology, Volume 31, Issue 2, Page 339-355, March 2025.
Effecft of co‐doping polyaniline with phosphoric acid and phytic acid on the heat release rate of polyethylene. Abstract Polyolefins, such as polyethylene (PE), are highly flammable and electrically insulative, limiting their applicability. The study explored the flame‐retardancy and electrical conductivity of PE/polyaniline (PE/PANI) nanocomposites ...
Akeem Adisa, Joseph K. O. Asante, Vincent O. Ojijo, António B. Mapossa, Washington Mhike   +4 more
wiley   +1 more source

α‐Synuclein strain homogeneity in multiple system atrophy subtypes

Brain Pathology, EarlyView.
Two different subtypes of multiple system atrophy are recognized: MSA‐C and MSA‐P. In this manuscript, Lau et al. investigate whether MSA‐C and MSA‐P are caused by different strains of α‐synuclein aggregates. By performing conformational fingerprinting experiments as well as in vitro and in vivo seeding assays, their findings suggest that both MSA‐C ...
Heather H. C. Lau, Nicholas R. G. Silver, Surabhi Mehra, Raphaella W. L. So, Le yao Li, Alison Mao, Erica Stuart, Cian Schmitt‐Ulms, Bradley T. Hyman, Martin Ingelsson, Joel C. Watts   +10 more
wiley   +1 more source

Selective modulation of NaV channel gating counteracts aberrant hyperexcitability and rescues motor function and survival in a model of spinal muscular atrophy

British Journal of Pharmacology, EarlyView.
Background and Purpose Spinal muscular atrophy (SMA) is a motor neuron disease caused by SMN1 gene loss, leading to reduced survival motor neuron (SMN) protein and progressive motor neuron degeneration. Although SMN‐restoring therapies improve outcomes, residual disease burden and non‐curative efficacy underscore the need for complementary treatments ...
Fernanda C. Cardoso, Jessica A. I. Muller, Yougang Zhang, Jean Giacomotto   +3 more
wiley   +1 more source

Occupational Allergic Contact Dermatitis From Over‐Ear Headphones: Chemical Analysis Reveals Octylisothiazolinone and Other Potential Skin Sensitizers

Contact Dermatitis, EarlyView.
ABSTRACT Background Over‐ear headphones are a growing source of allergic contact dermatitis (ACD). Identifying well‐known and new culprit sensitizers in such products is challenging because of a lack of labelling and limited cooperation from manufacturers.
Goël Fenech, Eddy Langlois, Eric Pelletier, Catherine Champmartin, Lynda Bensefa‐Colas, Marie‐Noëlle Crepy   +5 more
wiley   +1 more source

Occupational Allergic Contact Dermatitis due to Rubber Additives in Tunisia: A 27‐Year Retrospective Study of Clinical and Occupational Characteristics

Contact Dermatitis, EarlyView.
This study analyses data from 80 patients with occupational allergic contact dermatitis due to rubber additives in Tunisia, showing predominant sensitization to thiurams, frequent glove‐related exposure and major involvement of healthcare workers.
Emna Baraketi, Jihen Hsinet, Nihel Khouja, Aida Benzarti   +3 more
wiley   +1 more source

Directional information flow in human frataxin defines allosteric pathways connecting the hydrophobic core to the iron‐binding ridge

The FEBS Journal, EarlyView.
Human frataxin deficiency causes Friedreich's ataxia, yet how iron‐binding events are communicated across the protein is unclear. Using transfer entropy analysis of molecular dynamics simulations, we identify buried hydrophobic core leucines (LEU136, LEU140) as the source of directional signaling toward the iron‐binding acidic ridge.
Kevser Kübra Kırboğa, Ecir Uğur Küçüksille   +1 more
wiley   +1 more source

Guanidine-Based Ligands in Bioinorganic Chemistry: Coordination Modes and Applications in Anticancer Metallodrugs. [PDF]

Bioinorg Chem Appl
Del Campo-Balguerías A, Ocaña A, Bravo I, Alonso-Moreno C.   +3 more
europepmc   +1 more source

Constrictions and shear stress are key determinants of amyloidogenic light chain (AL) amyloidosis

The FEBS Journal, EarlyView.
In this study, we investigate how flow constrictions and shear stress trigger cardiac antibody light chain (AL) fibril formation and deposition. We mimic the mechanical forces exerted by the heart and the microvasculature network using a mini‐peristaltic pump setup and a grid‐type microchannel network, respectively.
Yuji Goto, Keiichi Yamaguchi, Kichitaro Nakajima, Ikuko Yumen, Ruiming He, Hirokazu Matsuda, Tetsuichi Wazawa, Takeharu Nagai, Nobuhiro Tsukada, Suguru Yamamoto, Johannes Buchner, Hirotsugu Ogi   +11 more
wiley   +1 more source

Hydroquinone Oxidation by Redox-active Guanidines and Thioguanidines: Faster Conversion to High-Potential Than to Low-Potential Quinones. [PDF]

Chemistry
Wild U, Hübner O, Jaworski S, Kaifer E, Himmel HJ.   +4 more
europepmc   +1 more source