Protein Science, Volume 35, Issue 6, June 2026.Abstract Accumulation of misfolded proteins is a hallmark of many neurodegenerative diseases. To characterize such misfolded species in vivo, conformation‐specific antibodies are widely used; however, limited knowledge of antibody–epitope interactions often hampers mechanistic insight.
Yuki Shino +7 more
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Understanding the Phenotypic Heterogeneity Within the Sporadic Creutzfeldt–Jakob Disease MV1 Subtype
Neuropathology and Applied Neurobiology, Volume 52, Issue 3, June 2026.We present the clinical, pathological and prion biophysical features of three atypical cases of the MV1 subtype of sporadic Creutzfeldt–Jakob disease (sCJD). We propose that these heterozygous cases exist on a spectrum ranging from MM1‐like to VV1‐like phenotypes and recommend that subtyping be performed at pH 6.9 to avoid missing atypical or mixed ...
Satish K. Nemani +6 more
wiley +1 more source
eLife Assessment: Single-molecule Ligand Response of Guanidine-IV riboswitch
Ishier Raote
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Tissue Engineered Human Elastic Cartilage From Primary Auricular Chondrocytes for Ear Reconstruction
Advanced Functional Materials, Volume 36, Issue 36, 4 May 2026.Despite over three decades of research, no tissue‐engineered solution for auricular reconstruction in microtia patients has reached clinical translation. The key challenge lies in generating functional elastic cartilage ex vivo. Here, we integrate synergistic cell‐biomaterial strategies to engineer auricular grafts with mechanical and histological ...
Philipp Fisch +13 more
wiley +1 more source
DFT Investigation into the Role of Superbases as the Auxiliary Groups in CO<sub>2</sub> Reduction. [PDF]
MoleculesGlasovac Z, Kovačević B, Margetić D.
europepmc +1 more source
XCVI.—Some compounds of guanidine with sugars. Part I
, 1907 R. S. Morrell, Albert Ernest Bellars
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Beiträge zum Crystal Engineering mit N,N'-überbrückten Guanidinium-Salzen: Topologische Analyse privilegierter Wasserstoffbrückennetzwerke und Validierung durch Röntgenstrukturanalyse [PDF]
, 2013 Wüstenberg, Reinhold Gregor
core
Digital seed amplification assay for TDP‐43 aggregate quantification in CSF
Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.Abstract INTRODUCTION Dementia is commonly caused by underlying pathologies driven by misfolded protein aggregates. Although dementia subtypes have distinct mechanisms, overlapping symptoms make diagnosis without biomarkers difficult. Misdiagnosis has previously hindered drug development by enrolling patients non‐specifically in trials.
Ella Borberg +7 more
wiley +1 more source
Spectral Quantum Chemistry and Infrared Resonance Library for Data-Driven Molecular Spectroscopy. [PDF]
Sci DataKrishnadas A +3 more
europepmc +1 more source