Results 31 to 40 of about 37,354 (378)
Synthesis and Activity of Biomimetic Biofilm Disruptors [PDF]
, 2013 Biofilms are often associated with human bacterial infections, and the natural tolerance of biofilms to antibiotics challenges treatment. Compounds with antibiofilm activity could become useful adjuncts to antibiotic therapy.
Böttcher, Thomas +4 more
core +1 more source
Norbornane-based antibacterial agents: Benzyl and benzoyl substituted guanidines
European Journal of Medicinal Chemistry Reports, 2022 There is a pressing need to develop new antibiotics to replace those rendered ineffective as a result of widespread antimicrobial resistance. Naturally occurring cationic antimicrobial peptides (CAMPs) exhibit broad-spectrum antibacterial activity and ...
Gareth E. Boer +3 more
doaj +1 more source
Molecules, 2019 The screening of more than 30 million compounds derived from 81 small molecule libraries built on 81 distinct scaffolds identified pyrrolidine bis-cyclic guanidine library (TPI-1955) to be one of the most active and selective antiplasmodial libraries ...
David L. Perry +5 more
doaj +1 more source
Molecules, 2021 This paper reports the synthesis of branched alkylene guanidines using microfluidic technologies. We describe the preparation of guanidine derivatives at lower temperatures, and with significantly less time than that required in the previously applicable
Denis O. Shatalov +10 more
doaj +1 more source
Organocatalytic Enantioselective Henry Reactions [PDF]
, 2011 This is an open access article distributed under the Creative Commons Attribution License.A large number of interesting organocatalytic enantioselective protocols have been explored and successfully applied in the last decade.
Herrera, Raquel P. +2 more
core +2 more sources
Synthesis of an advanced intermediate of alfa-alloenduracididine from allylglycine
Orbital: The Electronic Journal of Chemistry, 2012 α-Alloenduracididine, 3-(2-amino-4,5-dihydro-1Himidazole-4-yl)-2-aminopropionic acid)1 and its diastereoisomer, enduracididine 2, are two nonproteinogenic amino acids isolated in 1968 from Streptomyces fungicidicus as part of a cyclopeptide the ...
Silvia Helena Cardoso +3 more
doaj +1 more source
Zinc-Catalyzed Guanylation Reaction of Amines to Carbodiimides/Isocyanate Leading to of Guanidines/Urea Derivatives Formation [PDF]
, 2016 [Not ...
Bhattacharjee, J +2 more
core +1 more source
CrystalsGuanidine-containing molecules are an interesting class of compounds within both medicinal and material sciences. Having knowledge of their tautomerism is key in designing guanidines that interact with biological and chemical receptors.
Vijayaragavan Elumalai +6 more
doaj +1 more source
An Expeditious and Greener Synthesis of 2-Aminoimidazoles in Deep Eutectic Solvents
Molecules, 2016 A high-yield one-pot two-step synthesis of 2-aminoimidazoles (2-AI), exploiting an under-air heterocyclodehydration process between α-chloroketones and guanidine derivatives, and using deep eutectic solvents (DESs) as nonconventional, “green” and ...
Martina Capua +6 more
doaj +1 more source
Chemical and Pharmaceutical Bulletin, 2010 Guanidines are categorized as strong organobases; however, their catalytic utility in organic synthesis has not been discussed thoroughly. The author's group has extensively and systematically studied their potential ability focusing on: 1) modified guanidines as chiral auxiliaries; 2) guanidinium ylides for aziridine formation; 3) the affinity of ...
openaire +3 more sources