Results 51 to 60 of about 15,901 (303)
PPP1R15A-mediated dephosphorylation of eIF2α is unaffected by Sephin1 or Guanabenz
eLife, 2017 Dephosphorylation of translation initiation factor 2 (eIF2α) terminates signalling in the mammalian integrated stress response (ISR) and has emerged as a promising target for modifying the course of protein misfolding diseases.
Ana Crespillo-Casado +4 more
doaj +1 more source
Phase‐Change Solvents for Thermally Switchable Ion Conduction in Organogels
Advanced Materials, EarlyView.Organogels containing salts dissolved in phase‐change solvents exhibit thermally switchable ion conduction. The organogels, which display an over 10 000‐fold on‐off ratio and high cycling stability, can be synthesized with a wide range of salts and customizable conductivity/temperature relations for applications in ionotronics and energy storage ...
Yi‐ming Yuan, Thomas B. H. Schroeder
wiley +1 more source
Beilstein Journal of Organic Chemistry, 2017 Depending on the reaction conditions, N,N’,N’’-tris(benzylamino)guanidinium salts can react with carboxylic acid chlorides to form either symmetrical N,N’,N’’-tris(N-acyl-N-benzylamido)guanidines 6 or mesoionic 4-amino-1,2,4-triazolium-3-hydrazinides 7 ...
Jan Szabo, Julian Greiner, Gerhard Maas
doaj +1 more source
Journal of Synthetic Organic Chemistry, Japan, 2003 AbstractFor Abstract see ChemInform Abstract in Full Text.
Tsutomu Ishikawa, Toshio Isobe
openaire +2 more sources
Chiral benzimidazoles as hydrogen bonding organocatalysts [PDF]
, 2015 Several bifunctional organocatalysts bearing the benzimidazole unit have been designed in order to act as bifunctional systems by hydrogen bonding. Chiral 2-aminobenzimidazoles are conformational rigid guanidines able to catalyze enantioselectively ...
Nájera, Carmen, Yus, Miguel
core +2 more sources
EIF1AX Nucleolar Condensates Enhance Susceptibilities for the Management of Endometrial Cancer
Advanced Science, EarlyView.This schematic illustrates the mechanism of a senolytic strategy in endometrial cancer. EIF1AX facilitates the incorporation of DDX21 into nucleolar condensates, an event that suppresses rDNA transcription and induces cellular senescence. The compound 2,5‐MeC exploits this pathway by promoting EIF1AX nucleolar translocation and condensate formation ...
Chengyu Lv +8 more
wiley +1 more source
Heterocycle-based bifunctional organocatalysts in asymmetric synthesis [PDF]
, 2016 Different chiral bifunctional organocatalysts derived from trans-cyclohexane-1,2-diamine bearing different types of guanidine units able to form-hydrogen bonding activation have been designed. Conformational rigid 2-aminobenzimidazoles bearing a tertiary
Gómez Bengoa, Enrique +2 more
core +2 more sources
Neddylation Targets and Stabilizes NLRP3 to Augment Inflammasome‐Mediated Colitis and Mood Disorder
Advanced Science, EarlyView.NLRP3 inflammasome contributes to colitis and mood disorder. This study demonstrates that neddylation targets NLRP3 at K287, which hinders its interaction with K48‐linked ubiquitination E3 Trim31 and thereby stabilizes it. Neddylation blockade in myeloid cells and microglia mitigates DSS‐induced colitis and psychological stress‐induced anxiety‐like ...
Wenbin Gai +13 more
wiley +1 more source
Catalisadores heterogêneos para a produção de monoésteres graxos (biodiesel)
Química Nova, 2011 The recent increase in the world biodiesel demand, along with the need to reduce costs while improving the environmental sustainability of the entire biodiesel production chain, have led to the search for heterogeneous catalysts that would be efficient ...
Claudiney Soares Cordeiro +3 more
doaj +1 more source
Mitochondria targeting molecular transporters: synthesis, lipophilic effect, and ionic complex
Drug Delivery, 2022 As mitochondria are potential therapeutic targeting sites for the treatment of human diseases, delivering cytotoxic drugs, antioxidants, and imaging molecules to mitochondria can provide new therapeutic opportunities.
Akula S. N. Murthy +6 more
doaj +1 more source