Results 51 to 60 of about 1,467 (160)

Guanidinoacetic acid supplementation on growth performance and molecular mechanisms of lean mass gain in nursery pigs [PDF]

Ciência Rural, 2020
: The objective with the present study was to evaluate the effect of guanidinoacetic acid (GAA) on the growth performance of nursery piglets as well as a possible molecular mechanism of action on lean mass gain. Seventy-two pigs, weaned at 21 d, weighing
Graziela Alves da Cunha Valini, Marcio de Souza Duarte, Gustavo de Amorim Rodrigues, Renata Veroneze, Alysson Saraiva, Gary Hausman, Gabriel Cipriano Rocha   +6 more
doaj   +1 more source

Effects of feeding guanidinoacetic acid on oxidative status and creatine metabolism in broilers subjected to chronic cyclic heat stress in the finisher phase

Poultry Science, 2023
: Dietary guanidinoacetic acid (GAA) has been shown to affect creatine (Cr) metabolic pathways resulting in increased cellular Cr and hitherto broiler performances. Yet, the impact of dietary GAA on improving markers of oxidative status remains equivocal.
M. Majdeddin, U. Braun, A. Lemme, A. Golian, H. Kermanshahi, S. De Smet, J. Michiels   +6 more
doaj   +1 more source

Molecular and cellular mechanisms underlying gyrate atrophy: Why is the retina primarily affected?

Acta Ophthalmologica, Volume 103, Issue 7, Page e436-e455, November 2025.
Abstract Gyrate atrophy of the choroid and retina (GACR; OMIM #258870) is a rare early‐onset autosomal recessive disorder, caused by bi‐allelic pathogenic variants in the gene coding for ornithine aminotransferase (OAT) resulting in hyperornithinaemia.
Mark J. N. Buijs, Berith M. Balfoort, Marion M. Brands, Anneloor L. M. A. ten Asbroek, Camiel J. F. Boon, Roselie M. H. Diederen, Corrie Timmer, Margreet A. E. M. Wagenmakers, Hans R. Waterham, Ronald J. A. Wanders, Riekelt H. Houtkooper, Clara D. van Karnebeek, Arthur A. Bergen   +12 more
wiley   +1 more source

Dynamic electro‐clinical features in Guanidinoacetate N‐methyltransferase deficiency: A familial case series

Epilepsia Open, Volume 10, Issue 4, Page 1244-1252, August 2025.
Abstract Guanidinoacetate N‐methyltransferase deficiency is an inborn error of creatine metabolism, responsible for the absent conversion of guanidinoacetic acid into creatine, resulting in cerebral creatine deficit. It could present a variety of symptoms such as neurodevelopmental delay, epilepsy, movement disorder (ataxia, dystonia, and chorea), and ...
Mariapaola Schifino, Emanuele Bartolini, Stefano Pagano, Camilla Meossi, Rosa Pasquariello, Roberta Battini   +5 more
wiley   +1 more source

Dietary guanidinoacetic acid increases the longissimus dorsi muscle depth of finishing pigs without requiring a higher standardised ileal digestible methionine + cysteine concentration

Italian Journal of Animal Science, 2022
The objective of this study was to evaluate the interaction of guanidinoacetic acid (GAA) with standardised ileal digestible methionine + cysteine (SID Met + Cys) levels in finishing pig diets on the performance, carcase characteristics, pork quality ...
Natália Yoko Sitanaka, Alice Eiko Murakami, Lucas Antônio Costa Esteves, Paula Carina de Oliveira, Eliane Gasparino, Angélica de Souza Khatlab, Paulo Cesar Pozza   +6 more
doaj   +1 more source

Long‐Term Efficacy and Tolerability of Pegzilarginase in Arginase 1 Deficiency: Results of Two International Multicentre Open‐Label Extension Studies

Journal of Inherited Metabolic Disease, Volume 48, Issue 4, July 2025.
ABSTRACT Arginase 1 deficiency (ARG1‐D) is an autosomal recessive urea cycle disorder characterised by chronic hyperargininaemia, progressive spasticity, loss of mobility, and cognitive dysfunction. Standard of care (SOC), based on dietary protein restriction, rarely prevents progression.
Markey McNutt, Frank Rutsch, Rossana Sanchez Russo, Serena Gasperini, Spyros Batzios, Elisa Leão Teles, Anaïs Brassier, Jaya Ganesh, Andreas Schulze, Gregory M. Enns, Mattias Rudebeck   +10 more
wiley   +1 more source

Effect of Dietary Guanidinoacetic Acid Levels on the Mitigation of Greenhouse Gas Production and the Rumen Fermentation Profile of Alfalfa-Based Diets

Animals, 2023
The objective of this study was to evaluate the effect of different percentages of alfalfa (Medicago sativa L.) hay (AH) and doses of guanidinoacetic acid (GAA) in the diet on the mitigation of greenhouse gas production, the in vitro rumen fermentation ...
Oscar Vicente Vazquez-Mendoza, Veronica Andrade-Yucailla, Mona Mohamed Mohamed Yasseen Elghandour, Diego Armando Masaquiza-Moposita, Jorge Adalberto Cayetano-De-Jesús, Edwin Rafael Alvarado-Ramírez, Moyosore Joseph Adegbeye, Marcos Barros-Rodríguez, Abdelfattah Zeidan Mohamed Salem   +8 more
doaj   +1 more source

Enhancing transporter activity in heterologous expression systems with SAHA: a 2500‐times more potent and odorless alternative to butyrate

FEBS Open Bio, Volume 15, Issue 6, Page 906-913, June 2025.
Heterologous expression of membrane transporters in cultured cells is essential for functional characterization, but is sometimes limited by low activity. Our study compares the HDAC inhibitors butyrate, VPA and SAHA to enhance transport activity. We propose to replace butyrate by SAHA: it is equally effective, devoid of repulsive odor, costs less, and
Svenja Flögel, Maurice Tust, Samira Boussettaoui, Dietmar Fischer, Dirk Gründemann   +4 more
wiley   +1 more source

Homoarginine, the methylene homologue of arginine, as a substrate of human arginine:glycine amidinotransferase and arginases

Бюллетень сибирской медицины, 2018
L-homoarginine (hArg) is a non-coding amino acid, the blood level reduction of which is associated with an increased risk of stroke and heart attack.
E. S. Alekseevskaya, T. F. Subbotina, A. A. Zhloba   +2 more
doaj   +1 more source

Age-Related Changes in Serum Guanidinoacetic Acid in Women

Physiological Research, 2019
Guanidinoacetic acid (GAA) is a fundamental intermediate in cellular bioenergetics, with circulating levels of GAA often reflects disturbances in its conversion due to many intrinsic and extrinsic factors, including gender or age. Here, we evaluated serum GAA in 172 healthy women aged 18 to 65 years, with age found to significantly predict serum GAA ...
A, Olah, V, Stajer, L, Ratgeber, J, Betlehem, S M, Ostojic   +4 more
openaire   +2 more sources