Results 61 to 70 of about 1,467 (160)

Supplementation with Guanidinoacetic Acid in Women with Chronic Fatigue Syndrome [PDF]

Nutrients, 2016
A variety of dietary interventions has been used in the management of chronic fatigue syndrome (CFS), yet no therapeutic modality has demonstrated conclusive positive results in terms of effectiveness. The main aim of this study was to evaluate the effects of orally administered guanidinoacetic acid (GAA) on multidimensional fatigue inventory (MFI ...
Sergej Ostojic, Marko Stojanovic, Patrik Drid, Jay Hoffman, Damir Sekulic, Natasa Zenic   +5 more
openaire   +3 more sources

Oxidative stress‐induced changes in wooden breast and mitigation strategies: A review

Comprehensive Reviews in Food Science and Food Safety, Volume 24, Issue 2, March 2025.
Abstract Wooden breast (WB) is a multifactorial muscular abnormality resulting from the interplay between genetic predispositions for rapid growth, physiological stress, and anatomical impairments. This myopathy has been a persistent challenge in the poultry industry since its initial identification a decade ago.
Yaqin Wang, Binbin Li, Ching Jian, Mohammed Gagaoua, Mario Estévez, Eero Puolanne, Per Ertbjerg   +6 more
wiley   +1 more source

A creatine efflux transporter in oligodendrocytes

The FEBS Journal, Volume 292, Issue 5, Page 1124-1140, March 2025.
Creatine deficiency leads to severe neurodevelopmental disorders. In the brain, creatine is synthesized by oligodendrocytes to supply neighboring neurons. While SLC6A8 mediates neuronal uptake, the creatine release mechanism was unclear. Our results establish SLC22A15 as a key creatine efflux transporter.
Svenja Flögel, Miriam Strater, Dietmar Fischer, Dirk Gründemann   +3 more
wiley   +1 more source

Effects of patent foramen ovale in migraine: a metabolomics‐based study

The Journal of Physiology, Volume 603, Issue 4, Page 809-835, 15 February 2025.
Abstract figure legend Aura, cystatin‐C and calcium are biomarkers of PFO in migraine. PFO closure relieves migraine by regulating 5‐HT metabolism and redox reactions, especially in the posterior head. cTTE, contrast‐transthoracic echocardiography; DESI‐MSI, desorption electrospray ionization mass imaging; H&E, haematoxylin and eosin; PFO, patent ...
Bosi Dong, Xin Li, Lu Zhang, Ge Liang, Wen Zheng, Luolan Gui, Shuming Ji, Yusha Tang, Hua Li, Wanling Li, Ruiqi Yang, Yajiao Li, Anjiao Peng, Yucheng Chen, Meng Gong, Lei Chen   +15 more
wiley   +1 more source

Novel Insights Into Gyrate Atrophy of the Choroid and Retina (GACR): A Cohort Study

Journal of Inherited Metabolic Disease, Volume 48, Issue 1, January 2025.
ABSTRACT Gyrate atrophy of the choroid and retina (GACR, OMIM #258870) is a rare inherited metabolic disorder characterized by progressive chorioretinal degeneration and hyperornithinemia. Current therapeutic modalities potentially slow disease progression but are not successful in preventing blindness.
Berith M. Balfoort, Filip Van den Broeck, Camiel J. F. Boon, Martijn C. G. J. Brouwers, Roselie M. H. Diederen, Preet Dhillon, GACR “Bird's Eye View” Consortium, Anneloor L.M.A. Ten Asbroek, Berith M. Balfoort, Arthur A. Bergen, Camiel J.F. Boon, Marion M. Brands, Mark J.N. Buijs, Roselie M.H. Diederen, Sacha Ferdinandusse, Riekelt H. Houtkooper, Clara D. M. Van Karnebeek, Patrick Schultink, Corrie Timmer, Frédéric M. Vaz, Margreet A.E.M. Wagenmakers, Ronald J.A. Wanders, Hans R. Waterham, Frits Wijburg, Peter M. van Hasselt, Bregje Jaeger, Jessica S. Karuntu, Alexander J. M. Rennings, Francjan J. van Spronsen, Corrie Timmer, Margreet A. E. M. Wagenmakers, Julie De Zaeytijd, Bart P. Leroy, Andreas Schulze, Clara D. van Karnebeek, Marion M. Brands   +35 more
wiley   +1 more source

Positive Clinical, Neuropsychological, and Metabolic Impact of Liver Transplantation in Patients With Argininosuccinate Lyase Deficiency

Journal of Inherited Metabolic Disease, Volume 48, Issue 1, January 2025.
ABSTRACT Liver transplantation (LTx) is increasingly used in Urea Cycle Defects (UCDs) to prevent recurrent hyperammonemia and related neurological irreversible injury. Among UCDs, argininosuccinate lyase deficiency (ASLD) has a more complex phenotype than other UCDs, with long‐term neurocognitive deficits.
Barbara Siri, Benedetta Greco, Diego Martinelli, Sara Cairoli, Alessia Guarnera, Daniela Longo, Antonio Napolitano, Chiara Parrillo, Lucilla Ravà, Raffaele Simeoli, Gionata Spagnoletti, Roberta Taurisano, Silvio Veraldi, Andrea Pietrobattista, Marco Spada, Carlo Dionisi‐Vici   +15 more
wiley   +1 more source

Proton Magnetic Resonance Spectroscopy of the Developing Human Brain

Clinical Neuroimaging, Volume 2, Issue 1, 2025.
ABSTRACT Neurodevelopmental disorders are pervasive and pose a significant public health problem. Many of these disorders can have a lifelong impact on the quality of life and may affect an individual's ability to function independently. In numerous pediatric and fetal neurological disorders, biochemical alterations precede or mediate structural and ...
Firoozeh Shomal Zadeh, Qinqin Yang, Ali Gholipour, Camilo Jaimes   +3 more
wiley   +1 more source

Creatine Ameliorates the Adverse Effects of High‐Fat Diet on Hepatic Lipid Metabolism via Activating Mfn2‐Mediated Mitochondrial Fusion in Juvenile Grass Carp

Aquaculture Nutrition, Volume 2025, Issue 1, 2025.
With the increasing prevalence of high‐fat diets (HFD) in aquaculture practices, the detrimental effects of HFD on farmed fish have garnered significant attention. Creatine has emerged as a promising green feed additive for aquaculture species; however, its potential role in mitigating the negative impacts of HFD remains poorly understood.
Nan-Jun Hu, Guang-Li Feng, Xiao-Hong Lai, Mo Peng, Yu-Feng Song, Shouqi Xie   +5 more
wiley   +1 more source

The central role of creatine and polyamines in fetal growth restriction

The FASEB Journal, Volume 38, Issue 23, 15 December 2024.
Placental insufficiency is often associated with FGR. Placental biopsies and organoids (PlOs) from AGA, SGA, and FGR placentas were analyzed using transcriptomics and metabolomics. Significant metabolic changes were detected in FGR placentas and PlOs, including adaptations to low oxygen levels and altered arginine metabolism in polyamine and creatine ...
Eros Di Giorgio, Serena Xodo, Maria Orsaria, Laura Mariuzzi, Raffaella Picco, Vanessa Tolotto, Ylenia Cortolezzis, Francesca D'Este, Nicole Grandi, Lorenza Driul, Ambrogio Londero, Luigi E. Xodo   +11 more
wiley   +1 more source

Guanidinoacetic Acid Consumption via Regular Diet in Adults [PDF]

Annals of Nutrition and Metabolism, 2021
Sergej M. Ostojic, Valdemar Stajer, Laszlo Ratgeber, Jozsef Betlehem, Pongrac Acs   +4 more
openaire   +2 more sources