Results 51 to 60 of about 201,610 (282)
Back-electron transfer suppresses the periodic length dependence of DNA-mediated charge transport across adenine tracts [PDF]
, 2008 DNA-mediated charge transport (CT) is exquisitely sensitive to the integrity of the bridging π-stack and is characterized by a shallow distance dependence. These properties are obscured by poor coupling between the donor/acceptor pair and the DNA bridge,
Augustyn, Katherine E. +4 more
core +2 more sources
NanomaterialsCisplatin-based platinum compounds are important clinical chemotherapeutic agents that participate in most tumor chemotherapy regimens. Through density-functional theory calculations, the formation and stability of the inorganic oxide carrier, the ...
Zhenjun Song +6 more
doaj +1 more source
Gut and Liver, 2020 Background/Aims: Renal toxicity is a concern in patients with chronic hepatitis B taking nucleotide analogues, such as adefovir (ADV) and tenofovir disoproxil fumarate (TDF).
Young Youn Cho +8 more
doaj +1 more source
G-quartet biomolecular nanowires
, 2002 We present a first-principle investigation of quadruple helix nanowires, consisting of stacked planar hydrogen-bonded guanine tetramers. Our results show that long wires form and are stable in potassium-rich conditions.
Calzolari, A. +3 more
core +1 more source
Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif [PDF]
, 2017 Heterotrimeric G proteins are quintessential signalling switches activated by nucleotide exchange on Gα. Although activation is predominantly carried out by G-protein-coupled receptors (GPCRs), non-receptor guanine-nucleotide exchange factors (GEFs) have
Baillie, George S. +14 more
core +1 more source
The role of alkali metal cations in the stabilization of guanine quadruplexes: why K(+) is the best.
Physical Chemistry, Chemical Physics - PCCP, 2016 The alkali metal ion affinity of guanine quadruplexes has been studied using dispersion-corrected density functional theory (DFT-D). We have done computational investigations in aqueous solution that mimics artificial supramolecular conditions where ...
F. Zaccaria +2 more
semanticscholar +1 more source
The Journal of Organic Chemistry, 2023 Guanine is one out of five endogenous nucleobases and of key interest in drug discovery and chemical biology. Hitherto, the synthesis of guanine derivatives involves lengthy multistep sequential synthesis of low overall diversity, resulting in the quest for innovation. Using a "single-atom skeletal editing" approach, we designed 2-aminoimidazo[2,1-f][1,
Xin Li +4 more
openaire +3 more sources
CellsThe evolutionary loss of ednrb2 in specific vertebrate lineages, such as mammals and cypriniform fish, raises fundamental questions about its functional necessity and potential redundancy or synergy with paralogous endothelin receptors in pigment cell ...
Zilong Wen +7 more
doaj +1 more source
Application of Ammonium Persulfate for Selective Oxidation of Guanines for Nucleic Acid Sequencing
Molecules, 2017 Nucleic acids can be sequenced by a chemical procedure that partially damages the nucleotide positions at their base repetition. Many methods have been reported for the selective recognition of guanine.
Yafen Wang +7 more
doaj +1 more source
Guanine crystal formation by bacteria
BMC Biology, 2023 Background Guanine crystals are organic biogenic crystals found in many organisms. Due to their exceptionally high refractive index, they contribute to structural color and are responsible for the reflective effect in the skin and visual organs in ...
María Elisa Pavan +5 more
doaj +1 more source