Results 61 to 70 of about 158,534 (314)
Universal 1/f noise, cross-overs of scaling exponents, and chromosome specific patterns of GC content in DNA sequences of the human genome [PDF]
Physical Review E, 71, 041910 (2005), 2004 Spatial fluctuations of guanine and cytosine base content (GC%) are studied by spectral analysis for the complete set of human genomic DNA sequences. We find that (i) the 1/f^alpha decay is universally observed in the power spectra of all twenty-four chromosomes, and that (ii) the exponent alpha \approx 1 extends to about 10^7 bases, one order of ...
arxiv +1 more source
RhoA and Rac1 as Mechanotransduction Mediators in Colorectal Cancer
Advanced Biology, EarlyView.Analysing RhoA and Rac1 protein levels in Colorectal cancer (CRC) samples under mechanical strain highlights their potential as diagnostic markers. Monitoring their activity could offer valuable insights into how cancer spreads, paving the way for new approaches to better understand and diagnose colorectal cancer.
Sharda Yadav +5 more
wiley +1 more source
Spectral Analysis of Guanine and Cytosine Fluctuations of Mouse Genomic DNA [PDF]
Fluctuation and Noise Letters, 4(3):L453-L464 (2004), 2004 We study global fluctuations of the guanine and cytosine base content (GC%) in mouse genomic DNA using spectral analyses. Power spectra S(f) of GC% fluctuations in all nineteen autosomal and two sex chromosomes are observed to have the universal functional form S(f) \sim 1/f^alpha (alpha \approx 1) over several orders of magnitude in the frequency ...
arxiv +1 more source
Advanced Engineering Materials, EarlyView.Molecular dynamics simulations are advancing the study of ribonucleic acid (RNA) and RNA‐conjugated molecules. These developments include improvements in force fields, long‐timescale dynamics, and coarse‐grained models, addressing limitations and refining methods.
Kanchan Yadav, Iksoo Jang, Jong Bum Lee
wiley +1 more source
Radiological Evaluation of Huntington’s Disease: A Case Report [PDF]
Journal of Clinical and Diagnostic ResearchHuntington’s Disease (HD) is a rare neurodegenerative condition inherited in an autosomal dominant pattern, where Gamma Amino Butyric Acid-ergic (GABAergic) neurons in the basal ganglia progressively deteriorate.
Soumyabrata Debnath, R Harshith
doaj +1 more source
Chemistry & Biology, 1997 iso-Guanine (iso-G) is the purine component of an isomeric Watson-Crick base pair that may have existed prebiotically. By comparing the abiotic molecular recognition properties of iso-G and its complement, iso-cytosine (iso-C), with those of genomic nucleotide bases, it may be possible to explain the exclusion of the iso-G-iso-C base pair from modern ...
Christopher Switzer +2 more
openaire +3 more sources
Converting the Guanine Phosphoribosyltransferase from Giardia lamblia to a Hypoxanthine-guanine Phosphoribosyltransferase [PDF]
Journal of Biological Chemistry, 2000 Guanine phosphoribosyltransferase from Giardia lamblia, a key enzyme in the purine salvage pathway, is a potential target for anti-giardiasis chemotherapy. Recent structural determination of GPRTase (Shi, W., Munagala, N. R., Wang, C. C., Li, C. M., Tyler, P. C., Furneaux, R. H., Grubmeyer, C., Schramm, V. L., and Almo, S. C.
Narsimha R. Munagala +2 more
openaire +3 more sources
Chiral Engineered Biomaterials: New Frontiers in Cellular Fate Regulation for Regenerative Medicine
Advanced Functional Materials, EarlyView.Chiral engineered biomaterials can selectively influence cell behaviors in regenerative medicine. This review covers chiral engineered biomaterials in terms of their fabrication methods, cellular response mechanisms, and applications in directing stem cell differentiation and tissue function.
Yuwen Wang +5 more
wiley +1 more source
Rheoscopic Fluids in a Post-Kalliroscope World [PDF]
D. Borrero-Echeverry, C.J. Crowley and T.P. Riddick, Phys. Fluids
30, 087103 (2018), 2018 In rheoscopic flow visualization, the working fluid is seeded with small reflective flakes that align preferentially in the flow due to their anisotropy. This leads to directed light scattering, which can be exploited to distinguish qualitatively different regions of the flow.
arxiv +1 more source
Real-Time Monitoring of Human Guanine Deaminase Activity by an Emissive Guanine Analog
ACS Chemical Biology, 2021 Guanine deaminase (GDA) deaminates guanine to xanthine. Despite its significance, the study of human GDA remains limited compared to other metabolic deaminases. As a result, its substrate and inhibitor repertoire are limited, and effective real-time activity, inhibitory, and discovery assays are missing.
Bucardo M. S. +5 more
openaire +5 more sources