Results 61 to 70 of about 201,610 (282)

Associations between purine metabolites and clinical symptoms in schizophrenia [PDF]

, 2012
Background: The antioxidant defense system, which is known to be dysregulated in schizophrenia, is closely linked to the dynamics of purine pathway. Thus, alterations in the homeostatic balance in the purine pathway may be involved in the pathophysiology
Debra M. Montrose, George G. Dougherty, Jeffrey K. Yao, Joseph McEvoy, Kenji Hashimoto, Matcheri S. Keshavan, Ravinder D. Reddy, Rima Kaddurah-Daouk, Ruth Condray, Wayne R. Matson   +9 more
core   +3 more sources

Silver (I) as DNA glue: Ag+-mediated guanine pairing revealed by removing Watson-Crick constraints

Scientific Reports, 2015
Metal ion interactions with DNA have far-reaching implications in biochemistry and DNA nanotechnology. Ag+ is uniquely interesting because it binds exclusively to the bases rather than the backbone of DNA, without the toxicity of Hg2+.
S. Swasey, L. E. Leal, O. Lopez-Acevedo, James Pavlovich, E. Gwinn   +4 more
semanticscholar   +1 more source

Guanine in Fishes' Skins [PDF]

Nature, 1895
IN a joint paper by Mr. J. T. Cunningham and myself (Phil. Trans. vol. clxxxiv., 1893, B, pp. 765–812), we have ventured to question the accuracy of the statement made in many text-books of physiological chemistry, that guanine occurs in combination with calcium in the skin of fishes. We found that the guanine occurs in the free state.
openaire   +2 more sources

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Ab initio study of electron transport in dry poly(G)-poly(C) A-DNA strands

, 2010
The bias-dependent transport properties of short poly(G)-poly(C) A-DNA strands attached to Au electrodes are investigated with first principles electronic transport methods.
Chen, X., Pemmaraju, C. D., Rocha, A. R., Rungger, I., Sanvito, S.   +4 more
core   +1 more source

Mechanisms of base selection by human single-stranded selective monofunctional uracil-DNA glycosylase [PDF]

, 2009
hSMUG1 (human single-stranded selective monofunctional uracil-DNA glyscosylase) is one of three glycosylases encoded within a small region of human chromosome 12. Those three glycosylases, UNG (uracil-DNA glycosylase), TDG (thymine-DNA glyscosylase), and
Agus Darwanto, Akbari, Alcantara, Barrett, Bennett, Bethod, Boorstein, Bryantsev, Cerny, Clough, Cui, Cybulski, Daniel K. Rogstad, Di Noia, Di Noia, Dunning, Fujimoto, Gait, Guerniou, Hansch, Haushalter, Hobza, Jacob A. Theruvathu, James L. Sowers, Jang, Kavli, Kelly, Kendall, Krokan, Krokan, La Francois, Lawrence C. Sowers, Liu, Marten, Masaoka, Matsubara, Matsubara, Matsudaira, Mendes, Morgan, Neddermann, Nilsen, Nilsen, Pearl, Perezjorda, Privat, Rao, Rogstad, SantaLucia, Sibghat-Ullah, Slupphaug, Sousa, Sowers, Sowers, Sugiyama, Tannor, Tod Pascal, Waters, Wibley, William Goddard, Zhao, Zhao, Zhao, Zielenkiewicz   +63 more
core   +3 more sources

Guanine nucleotide binding to the Bateman domain mediates the allosteric inhibition of eukaryotic IMP dehydrogenases

Nature Communications, 2015
Inosine-5′-monophosphate dehydrogenase (IMPDH) plays key roles in purine nucleotide metabolism and cell proliferation. Although IMPDH is a widely studied therapeutic target, there is limited information about its physiological regulation.
R. Buey, Rodrigo Ledesma‐Amaro, A. Velázquez‐Campoy, M. Balsera, M. Chagoyen, J. M. de Pereda, J. Revuelta   +6 more
semanticscholar   +1 more source

Single cis‐elements in brassinosteroid‐induced upregulated genes are insufficient to recruit both redox states of the BIL1/BZR1 DNA‐binding domain

FEBS Letters, EarlyView.
Phytohormone brassinosteroid‐induced gene regulation by the transcription factor BIL1/BZR1 involves redox‐dependent DNA‐binding alternation and interaction with the transcription factor PIF4. The reduced BIL1/BZR1 dimer binds preferred cis‐elements, while oxidation alters its oligomerization state and disrupts DNA‐binding ability.
Shohei Nosaki, Masae Ohtsuka, Takeshi Nakano, Masaru Tanokura, Takuya Miyakawa   +4 more
wiley   +1 more source

Intracellular metabolites in marine microorganisms during an experiment evaluating microbial mortality [PDF]

, 2020
© The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Longnecker, K., & Kujawinski, E. B.
Kujawinski, Elizabeth B., Longnecker, Krista   +1 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source