Role of ARHGEF3 as a GEF and mTORC2 Regulator
Frontiers in Cell and Developmental Biology, 2022 Guanine nucleotide exchange factors (GEFs) activate GTPases by stimulating the release of guanosine diphosphate to permit the binding of guanosine triphosphate.
Sana Abdul Khaliq +5 more
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Targeting Rac and Cdc42 GEFs in Metastatic Cancer
Frontiers in Cell and Developmental Biology, 2020 The Rho family GTPases Rho, Rac, and Cdc42 have emerged as key players in cancer metastasis, due to their essential roles in regulating cell division and actin cytoskeletal rearrangements; and thus, cell growth, migration/invasion, polarity, and adhesion.
Maria del Mar Maldonado +3 more
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Divergent Mechanisms Activating RAS and Small GTPases Through Post-translational Modification
Frontiers in Molecular Biosciences, 2021 RAS is a founding member of the RAS superfamily of GTPases. These small 21 kDa proteins function as molecular switches to initialize signaling cascades involved in various cellular processes, including gene expression, cell growth, and differentiation ...
Natsuki Osaka +18 more
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Novel insights into the RTK-dependent metastatic phenotype of KRAS-mutant lung adenocarcinoma
Molecular & Cellular Oncology, 2021 In a recent study, our group identified RAC guanine nucleotide exchange factors (RAC-GEFs) driving motility signaling in KRAS mutant lung adenocarcinoma cells.
Mariana Cooke
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Guanine Nucleotide Exchange Assay Using Fluorescent MANT-GDP
Bio-Protocol, 2018 GTPases are molecular switches that cycle between the inactive GDP-bound state and the active GTP-bound state. GTPases exchange nucleotides either by its intrinsic nucleotide exchange or by interaction with guanine nucleotide exchange factors (GEFs ...
Tomoharu Kanie, Peter Jackson
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Eukaryotic translation elongation factor 1A (eEF1A) domain I from S. cerevisiae is required but not sufficient for inter-species complementation [PDF]
, 2012 Ethanolamine phosphoglycerol (EPG) is a protein modification attached exclusively to eukaryotic elongation factor 1A (eEF1A). In mammals and plants, EPG is linked to conserved glutamate residues located in eEF1A domains II and III, whereas in the ...
Eva Greganova +5 more
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Influence of guanine nucleotides on complex formation between Ras and CDC25 proteins [PDF]
, 1993 The Saccharomyces cerevisiae CDC25 gene and closely homologous genes in other eukaryotes encode guanine nucleotide exchange factors for Ras proteins. We have determined the minimal region of the budding yeast CDC25 gene capable of activity in vivo.
Lai, C. C. +3 more
core +1 more source
Chlamydial entry involves TARP binding of guanine nucleotide exchange factors.
PLoS Pathogens, 2008 Chlamydia trachomatis attachment to cells induces the secretion of the elementary body-associated protein TARP (Translocated Actin Recruiting Protein).
B Josh Lane +4 more
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Clinical implication and potential function of ARHGEF6 in acute myeloid leukemia: An in vitro study.
PLoS ONE, 2023 The roles of Rho GTPases in various types of cancer have been extensively studied, but the research of Rho guanine nucleotide exchange factors (GEFs) in cancer is not comprehensive.
Kang Li +5 more
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Genetics and Molecular Biology, 2021 Pain is a significant problem worldwide that affects the quality of life of patients. Dezocine is a non-addictive analgesic drug with kappa-opioid antagonist activity and has been successfully used to alleviate of postoperative pain.
Xue Liu +6 more
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