Results 51 to 60 of about 84,425 (312)

High-Resolution Three-Dimensional NMR Structure Of The KRAS Proto-Oncogene Promoter Reveals Key Features Of A G-Quadruplex Involved In Transcriptional Regulation [PDF]

, 2017
Non-canonical base pairing within guanine-rich DNA and RNA sequences can produce G-quartets, whose stacking leads to the formation of a G-quadruplex (G4).
Ivashchenko, S., Kerkour, A., Marquevielle, J., Mergny, J.-L., Salgado, G. F., Yatsunyk, Liliya A.   +5 more
core   +2 more sources

The nuclear guanine nucleotide exchange factors Ect2 and Net1 regulate RhoB-mediated cell death after DNA damage. [PDF]

PLoS ONE, 2011
Commonly used antitumor treatments, including radiation and chemotherapy, function by damaging the DNA of rapidly proliferating cells. However, resistance to these agents is a predominant clinical problem.
Melissa C Srougi, Keith Burridge
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Identification of Naegleria fowleri proteins linked to primary amoebic meningoencephalitis [PDF]

, 2017
Naegleria fowleri (N. fowleri) causes primary amoebic meningoencephalitis, a rapidly fatal disease of the central nervous system. N. fowleri can exist in cyst, flagellate or amoebic forms, depending on environmental conditions.
Cabral, Guy A, Jamerson, Melissa, Marciano-Cabral, Francine, Park, Jay, Schmoyer, Jacqueline A   +4 more
core   +2 more sources

The Role of Chemistry Across Disciplines From Humanities to Life Sciences in Understanding Complexity and Emergence

Angewandte Chemie, EarlyView.
This study explores the origins of life by linking prebiotic chemistry, the emergence of information‐carrying molecules such as RNA and proteins, and philosophical questions about consciousness. The study emphasizes the role of molecular evolution in the Central Dogma and provides insights into the chemical origins of biology and the basis of life's ...
Harald Schwalbe, Josef Wachtveitl, Alexander Heckel, Florian Buhr, Sabrina Toews, Thomas M. Schimmer   +5 more
wiley   +2 more sources

The domain architecture of large guanine nucleotide exchange factors for the small GTP-binding protein Arf

BMC Genomics, 2005
Background Small G proteins, which are essential regulators of multiple cellular functions, are activated by guanine nucleotide exchange factors (GEFs) that stimulate the exchange of the tightly bound GDP nucleotide by GTP.
Geldner Niko, Shields David J, Cohen Jean, Joubert Alexandra, Biou Valerie, Mouratou Barbara, Jürgens Gerd, Melançon Paul, Cherfils Jacqueline   +8 more
doaj   +1 more source

Covalent Inhibitors Allosterically Block the Activation of Rho Family Proteins and Suppress Cancer Cell Invasion

Advanced Science, 2020
The Rho family GTPases are crucial drivers of tumor growth and metastasis. However, it is difficult to develop GTPases inhibitors due to a lack of well‐characterized binding pockets for compounds.
Zhongya Sun, Hao Zhang, Yuanyuan Zhang, Liping Liao, Wen Zhou, Fengcai Zhang, Fulin Lian, Jing Huang, Pan Xu, Rukang Zhang, Wenchao Lu, Mingrui Zhu, Hongru Tao, Feng Yang, Hong Ding, Shijie Chen, Liyan Yue, Bing Zhou, Naixia Zhang, Minjia Tan, Hualiang Jiang, Kaixian Chen, Bo Liu, Chuanpeng Liu, Yongjun Dang, Cheng Luo   +25 more
doaj   +1 more source

Dbl oncogene expression in MCF-10 A epithelial cells disrupts mammary acinar architecture, induces EMT and angiogenic factor secretion. [PDF]

, 2015
The proteins of the Dbl family are guanine nucleotide exchange factors (GEFs) of Rho GTPases and are known to be involved in cell growth regulation. Alterations of the normal function of these proteins lead to pathological processes such as developmental
Bosco MC, Cabodi S, Donnini S, Eva A., Finetti F, MANCINI, Patrizia, Ognibene M, Segalerba D, TORRISI, Maria Rosaria, Vanni C, Varesio L   +10 more
core   +1 more source

VAV3 (vav 3 guanine nucleotide exchange factor) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on VAV3 (vav 3 guanine nucleotide exchange factor), with data on DNA, on the protein encoded, and where the gene is implicated.
Lyons, L, Burnstein, KL
openaire   +2 more sources