Results 81 to 90 of about 9,354,840 (235)
Advanced Science, EarlyView.The maize BTB/POZ‐MATH (BPM) protein ZmBPM1 interacts with autophagy‐related protein ZmATG6 to relocate the NLR protein Rp1‐D21 from the nucleo‐cytoplasmic compartment into autophagosome‐like puncta, leading to autophagy‐mediated turnover and suppressing the hypersensitive response.
Chang‐Xiao Tang +8 more
wiley +1 more source
Integrated conformational and lipid-sensing regulation of endosomal ArfGEF BRAG2. [PDF]
PLoS Biology, 2013 The mechanisms whereby guanine nucleotide exchange factors (GEFs) coordinate their subcellular targeting to their activation of small GTPases remain poorly understood.
Kaheina Aizel +6 more
doaj +1 more source
Spatiotemporal regulation of Rap guanine nucleotide exchange factors [PDF]
, 2014 Guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs) orchestrate the activity of small G-proteins. In response to extracellular stimuli, GEFs and GAPs activate signaling cascades regulated by G-proteins by controlling their ...
Consonni, S.V.
core
Ras-Activated Endocytosis Is Mediated by the Rab5 Guanine Nucleotide Exchange Activity of RIN1 [PDF]
, 2001 RIN1 was originally identified by its ability to inhibit activated Ras and likely participates in multiple signaling pathways because it binds c-ABL and 14-3-3 proteins, in addition to Ras.
Tall, Gregory G. +3 more
core +1 more source
Quantum‐Level Influences on Enzyme Reactions and Their Ripple Effects on Biological Phenomena
Advanced Physics Research, EarlyView.Because living organisms are ultimately composed of atoms and molecules, quantum‐mechanical effects are expected to contribute to biological phenomena. Quantum biology seeks to elucidate life processes from a quantum‐mechanical perspective. This review discusses how quantum‐level effects, including quantum tunneling, may propagate from enzymatic proton‐
Takeshi Yasuda
wiley +1 more source
Functional Analysis of Cdc42 Residues Required for Guanine Nucleotide Exchange [PDF]
, 2002 Guanine nucleotide exchange factors (GEFs) directly engage small GTPases to facilitate the exchange of bound GDP for GTP, leading to GTPase activation. Several recent crystal structures of GEFs in complex with Rho family GTPases highlight the conserved ...
Whitehead, Ian P. +5 more
core +1 more source
BMEMat, EarlyView.Ultrasound‐responsive nanoplatforms reprogram the tumor immune microenvironment by targeting tumor cells, immune cells, and non‐immune stromal cells to enhance the efficacy of cancer immunotherapy. Abstract Cancer immunotherapy represents a significant advancement in cancer treatment by enhancing the specific recognition and elimination of cancer cells.
Shilong Zhao +4 more
wiley +1 more source
ARNO Is a Guanine Nucleotide Exchange Factor for ADP-ribosylation Factor 6 [PDF]
Journal of Biological Chemistry, 1998 ADP-ribosylation factors (ARFs) constitute a family of small monomeric GTPases. ARFs 1 and 3 function in the recruitment of coat proteins to membranes of the Golgi apparatus, whereas ARF6 is localized to the plasma membrane, where it appears to modulate both the assembly of the actin cytoskeleton and endocytosis.
S, Frank +3 more
openaire +2 more sources
A Small Molecule-Regulated Guanine Nucleotide Exchange Factor
, 2016 A Small Molecule-Regulated Guanine Nucleotide Exchange ...
Inna Goreshnik (2323045) +1 more
core +1 more source