Results 81 to 90 of about 41,746 (257)

Ras-Activated Endocytosis Is Mediated by the Rab5 Guanine Nucleotide Exchange Activity of RIN1

, 2001
RIN1 was originally identified by its ability to inhibit activated Ras and likely participates in multiple signaling pathways because it binds c-ABL and 14-3-3 proteins, in addition to Ras.
Tall, Gregory G., Barbieri, M.Alejandro, Stahl, Philip D., Horazdovsky, Bruce F.   +3 more
core   +1 more source

RNA‐centric world of retroviruses: unravelling the molecular strategies of genomic RNA packaging

Biological Reviews, EarlyView.
ABSTRACT Retroviruses constitute a unique group of RNA viruses that have profoundly influenced both evolutionary trajectories and biomedical research. Their ability to reverse transcribe and integrate into host genomes has shaped genomic architecture across species and contributed to our understanding of oncogenes, gene regulation, and RNA biology ...
Mohammad Abdullah Jehad, Suresha G. Prabhu, Lizna M. Ali, Vineeta N. Pillai, Farah Mustafa, Tahir A. Rizvi   +5 more
wiley   +1 more source

Loss of ARHGEF6 Causes Hair Cell Stereocilia Deficits and Hearing Loss in Mice

Frontiers in Molecular Neuroscience, 2018
ARHGEF6 belongs to the family of guanine nucleotide exchange factors (GEFs) for Rho GTPases, and it specifically activates Rho GTPases CDC42 and RAC1.
Chengwen Zhu, Chengwen Zhu, Chengwen Zhu, Cheng Cheng, Cheng Cheng, Cheng Cheng, Cheng Cheng, Yanfei Wang, Yanfei Wang, Waqas Muhammad, Waqas Muhammad, Shuang Liu, Weijie Zhu, Buwei Shao, Zhong Zhang, Xiaoqian Yan, Qingqing He, Zhengrong Xu, Chenjie Yu, Xiaoyun Qian, Ling Lu, Shasha Zhang, Shasha Zhang, Shasha Zhang, Shasha Zhang, Yuan Zhang, Wei Xiong, Xia Gao, Xia Gao, Zhigang Xu, Zhigang Xu, Renjie Chai, Renjie Chai, Renjie Chai, Renjie Chai, Renjie Chai   +35 more
doaj   +1 more source

Liposome reconstitution and modulation of recombinant prenylated human Rac1 by GEFs, GDI1 and Pak1. [PDF]

PLoS ONE, 2014
Small Rho GTPases are well known to regulate a variety of cellular processes by acting as molecular switches. The regulatory function of Rho GTPases is critically dependent on their posttranslational modification at the carboxyl terminus by ...
Si-Cai Zhang, Lothar Gremer, Henrike Heise, Petra Janning, Aliaksei Shymanets, Ion C Cirstea, Eberhard Krause, Bernd Nürnberg, Mohammad Reza Ahmadian   +8 more
doaj   +1 more source

Membrane‐Permeable Nucleoside T‐1106 Diphosphate and Triphosphate Analogues as Antiviral Pronucleotides

Chemistry – A European Journal, EarlyView.
Favipiravir (T‐705) and the non‐fluorinated counterpart (T‐1106) are antiviral agents that inhibit the RNA‐dependent RNA polymerase (RdRp) of various RNA viruses. The antiviral efficacy of nucleoside analogues is strongly dependent on their intracellular activation by cellular kinases to produce their corresponding triphosphate metabolites (T‐705‐RTP ...
Chris Meier, Duan Li, Leentje Persoons, Graciela Andrei, Robert Snoeck, Dominique Schols, Lieve Naesens, Xiao Jia   +7 more
wiley   +1 more source

Guanine Nucleotide Exchange Factor [PDF]

, 2006
  +5 more sources

Identification of novel genes regulating the development of the palate

Developmental Dynamics, EarlyView.
Abstract Background The International Mouse Phenotyping Consortium (IMPC) has generated thousands of knockout mouse lines, many of which exhibit embryonic or perinatal lethality. Using micro‐computed tomography (micro‐CT), the IMPC has created and publicly released three‐dimensional image data sets of embryos from these lethal and subviable lines.
Ashwin Bhaskar, Sophie Astrof
wiley   +1 more source

Activation of an Estrogen/ Estrogen Receptor Signaling by BIG3 Through Its Inhibitory Effect on Nuclear Transport of PHB2/REA in Breast Cancer

, 2009
Breast cancer is known to be a hormone-dependent disease, and estrogens through an interaction with estrogen receptor (ER) enhance the proliferative and metastatic activity of breast tumor cells.
Yusuke Nakamura, Tomomi Ueki, Miki Akiyama, Meng-Lay Lin, Arata Shimo, Jae-Hyun Park, Yataro Daigo, Toyomasa Katagiri, Tatsuhiko Tsunoda, Jung-Won Kim, Toshihiko Nishidate   +10 more
core  

Tomato EF-Tsmt, a functional mitochondrial translation elongation factor from higher plants [PDF]

, 2003
Ethylene-induced ripening in tomato (Lycopersicon esculentum) resulted in the accumulation of a transcript designated LeEF-Tsmt that encodes a protein with significant homology to bacterial Ts translational elongation factor (EF-Ts).
Jauneau, Alain, Li, Zhengguo, Zegzouti, Hicham, Chaves, Ana, Bouzayen, Mondher, Spremulli, Linda L., Delalande, Corinne, Latché, Alain, Zhengguo, Li, Pech, Jean-Claude, Benichou, Mohamed, Chavez, Ana, Tournier, Barthélémy, Audran-Delalande, Corinne   +13 more
core   +1 more source

The role of Rho GTPases in facial morphogenesis

Developmental Dynamics, EarlyView.
The role of small GTPases, RHOA, RAC1, and CDC42 and pathway mediators is reviewed in the context of embryonic facial development. Lip fusion requires cytoskeletal remodeling during morphogenesis of the facial processes and during lip fusion. Fnm, frontonasal mass; lnp, lateral nasal process; mnp, medial nasal process; mxp, maxillary process; np, nasal
Isra Ibrahim, Joy M. Richman
wiley   +1 more source