Results 121 to 130 of about 99,476 (367)
The Anatomical Record, EarlyView.Abstract The pygmy sperm whale (Kogia breviceps) possesses an exocrine gland associated with its false gill slit pigmentation pattern. The cervical gill slit gland is a compound tubuloalveolar gland that produces a holocrine secretion and displays maturational changes in size and secretory histology. While the morphology of the cervical gill slit gland
Tiffany F. Keenan +13 more
wiley +1 more source
Communications BiologyTransglutaminase 2 (TG2) is a GTP-binding, protein-crosslinking enzyme that has been investigated as a therapeutic target for Celiac disease, neurological disorders, and aggressive cancers.
Cody Aplin +7 more
doaj +1 more source
Animal Research and One Health, EarlyView.This study characterizes a multidrug‐resistant and strong biofilm‐forming Enterococcus faecalis strain obtained from a shrimp sample in Bangladesh. ABSTRACT Enterococcus faecalis is known for its ability to form strong biofilms and its role as an opportunistic pathogen. In this study, we screened and characterized a multidrug‐resistant (MDR) and strong
Md. Ashek Ullah +4 more
wiley +1 more source
Characterizing large scale base composition structures of genomes [PDF]
arXiv, 2004 Intermittent density fluctuations of nucleotide molecules (adenine, guanine, cytosine and thymine) along DNA sequences are studied in the framework of a hierarchical structure (HS) model originally proposed for the study of fully developed turbulence [She and Leque, Phys. Rev. Lett. 72}, 336 (1994)].
arxiv
Stability analysis of a signaling circuit with dual species of GTPase switches [PDF]
arXiv, 2020 GTPases are molecular switches that regulate a wide range of cellular processes, such as organelle biogenesis, position, shape, and signal transduction. These enzymes operate by toggling between an active ("ON") guanosine triphosphate (GTP)-bound state and an inactive ("OFF") guanosine diphosphate (GDP)-bound state; such a toggle is regulated by GEFs ...
arxiv
British Journal of Clinical Pharmacology, EarlyView.Aims Shunting (hypermethylating) thiopurine metabolism, characterized by excessive 6‐MMPR production and (sub)therapeutic 6‐TGN levels, poses a significant challenge in the treatment of inflammatory bowel disease (IBD). This study evaluates the metabolic outcomes of switching to low‐dose thiopurine with allopurinol (LDTA) or thioguanine (TG) in IBD ...
Ahmed B. Bayoumy +4 more
wiley +1 more source
The gateway to guanine nucleotides: Allosteric regulation of IMP dehydrogenases. [PDF]
Protein Sci, 2022 Buey RM +3 more
europepmc +1 more source
Correlation Between GC-content and Palindromes in Randomly Generated Sequences and Viral Genomes [PDF]
arXiv, 2013 GC-content, the ratio of guanine and cytosine bases in an entire nucleotide sequence, and palindromic sequences are unique for every organism due to genomic evolution. The goals of our research was to establish a correlation between GC-content and palindromic densities in wild-type viral and randomly-generated genomes.
arxiv
Methods for Controlling Small GTPase Activity
ChemBioChem, EarlyView.This concept highlights recent and emerging methods for controlling small GTPase activity, encompassing both small‐molecule‐based approaches and protein engineering strategies. The use of these approaches to advance the understanding of small GTPase function, current limitations, and future outlook is discussed.
Benjamin Faulkner +3 more
wiley +1 more source
Nature CommunicationsChemically modified nucleosi(ti)des and functional oligonucleotides (ONs, including therapeutic oligonucleotides, aptamer, nuclease, etc.) have been identified playing an essential role in the areas of medicinal chemistry, chemical biology, biotechnology,
Ruoqian Xie +8 more
doaj +1 more source