Results 121 to 130 of about 150,931 (301)

A Cytosine‑Bulged (3+1) Hybrid G‑Quadruplex Formed by the Chicken DNA Replication Origin

Chemistry – A European Journal, EarlyView.
The first high‐resolution structure of an OGRE‐derived G‐quadruplex from the chicken β‐globin replication origin reveals an intramolecular three‐layer (3+1) hybrid fold with a cytosine bulge and an unprecedented 5'‐outer‐quartet anti guanine, creating a distinctive surface for molecular recognition.
Yingying You, Monica Ching Suen, Haitao Miao, Yanyan Geng, Rahman Ud Din, Mu Yuan, Qiang Xue, Xiaoting Li, Naining Xu, Zhihong Guo, Hon‐Ming Lam, Kwok‐Wai Lo, Changdong Liu, Guang Zhu   +13 more
wiley   +1 more source

HPLC method to resolve, identify and quantify guanine nucleotides bound to recombinant ras GTPase. [PDF]

Anal Biochem, 2021
Hannan JP, Swisher GH, Martyr JG, Cordaro NJ, Erbse AH, Falke JJ.   +5 more
europepmc   +1 more source

Introduction of a Double‐Headed Nucleotide Into G‐Quadruplex DNA: Position‐Dependent Stabilization and Structural Insights

Chemistry – A European Journal, EarlyView.
A double‐headed bis‐guanine (G) nucleotide (GG) was evaluated as a noncanonical building block in G‐quadruplexes (G4s). Biophysical and computational analyses reveal that GG can directly participate in G‐tetrads and strongly stabilize G4s in a position‐ and topology‐dependent manner. These findings establish design rules for using GG to engineer highly
Krista Urup, Peter Reinholdt, Kasper Munch Beck, Michael Petersen, Jean‐Louis Mergny, Poul Nielsen   +5 more
wiley   +1 more source

Expression, purification, crystallization and X-ray data collection for RAS and its mutants

Data in Brief, 2016
This article expands on crystal structure data for human H-RAS with mutations at position Y137, briefly described in a paper on the effects of phosphorylation of Y137 by ABL kinases (Tyrosine phosphorylation of RAS by ABL allosterically enhances effector
Christian W. Johnson, Greg Buhrman, Pamela Y. Ting, John Colicelli, Carla Mattos   +4 more
doaj   +1 more source

Guanine nucleotide determination in extracts of wheat embryo

FEBS Letters, 1976
A number of recent studies have been concerned with the relationship between the rates of RNA and protein synthesis and the cellular levels of nucleotide triphosphates [l-4] . Prerequisite for such studies are methods for accurate nucleotide analysis. While in the case of the adenine nucleotides a number of satisfactory procedures have been described ...
Cheung, Chi P., Marcus, Abraham
openaire   +2 more sources

Estudo dos derivados da guanina como agentes protetores e tróficos em astrócitos e neurônios cerebelares [PDF]

, 2004
Dissertação (mestrado) - Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Programa de Pós-Graduação em Neurociências.Os nucleotídeos e o nucleosídeo derivados da guanina (DG) têm sido implicados em diversas funções extracelulares ...
Francisco, Sheila Regina Schmidt
core  

Characterization of the Immune Response after Oral Cholera Vaccination (OCV) and Effects of Mycophenolate Mofetil on Priming of this Immune Response—A Randomized, Placebo‐Controlled Trial

Clinical Pharmacology &Therapeutics, EarlyView.
Mycophenolate mofetil (MMF) is an immunosuppressive drug widely used by solid organ transplant recipients. Although it is known that MMF suppresses immune responses, its exact effects on specific vaccinations have not been investigated yet. Mucosal vaccinations are increasingly used, such as a cholera vaccination consisting of two oral immunizations ...
Boukje C. Eveleens Maarse, Aliede E. in 't Veld, Hendrika W. Grievink, Manon A.A. Jansen, Matthijs Moerland   +4 more
wiley   +1 more source

Diversity of mechanisms to control bacterial GTP homeostasis by the mutually exclusive binding of adenine and guanine nucleotides to IMP dehydrogenase. [PDF]

Protein Sci, 2022
Fernández-Justel D, Marcos-Alcalde Í, Abascal F, Vidaña N, Gómez-Puertas P, Jiménez A, Revuelta JL, Buey RM.   +7 more
europepmc   +1 more source

Influence of ground-state structure and Mg2+ binding on folding kinetics of the guanine-sensing riboswitch aptamer domain [PDF]

, 2011
Riboswitch RNAs fold into complex tertiary structures upon binding to their cognate ligand. Ligand recognition is accomplished by key residues in the binding pocket.
Julia Wirmer-Bartoschek, Anna Wacker, Wirmer-Bartoschek, J., Schwalbe, H., Wacker, A., Wirmer-Bartoschek, Julia, Eberhart Warkentin, Buck, Janina, Warkentin, E., Wacker, Anna, Wöhnert, Jens, Schwalbe, Harald, Harald Schwalbe, Wöhnert, J., Jens Wöhnert, Warkentin, Eberhart, Buck, J., Janina Buck   +17 more
core   +1 more source

The role of Rho GTPases in facial morphogenesis

Developmental Dynamics, EarlyView.
The role of small GTPases, RHOA, RAC1, and CDC42 and pathway mediators is reviewed in the context of embryonic facial development. Lip fusion requires cytoskeletal remodeling during morphogenesis of the facial processes and during lip fusion. Fnm, frontonasal mass; lnp, lateral nasal process; mnp, medial nasal process; mxp, maxillary process; np, nasal
Isra Ibrahim, Joy M. Richman
wiley   +1 more source