Results 231 to 240 of about 52,163 (306)

Mechanistic studies on HNRNPA2B1 suggest binding but not selective recognition of m⁶A. [PDF]

RNA Biol
Park R, Demny M, Miller LG, Pedraza C, Xenophontos X, Hunt RK, Orr AA, Perez LM, Montalbano M, Contreras LM, Tamamis P.   +10 more
europepmc   +1 more source

Long‐Term Salt Exposure Reprograms the Nicotiana tabacum BY‐2 Suspension Proteome and Metabolome Toward Stabilization of the Core Metabolic Pathways, Protein Turnover Machinery Modifications, and Protective Metabolome Adjustments

Plant, Cell &Environment, EarlyView.
ABSTRACT In this study, we analyzed a unique Nicotiana tabacum BY‐2 line that was gradually adapted to and subsequently maintained in 190 mM NaCl for over 15 years. Years of continuous high salinity shaped a stable “new homeostasis” in BY‐2 suspension cells. Salt‐adapted cells were smaller and formed tighter clusters. Metabolomics revealed constitutive
Anita Rzadkiewicz, Łukasz Marczak, Aleksander Strugała, Maria Tomys, Ewelina Ratajczak, Tomasz Skrzypczak, Przemysław Wojtaszek, Anna Kasprowicz‐Maluśki, Agnieszka Szuba   +8 more
wiley   +1 more source

Targeting <i>Plasmodium falciparum</i> with purine antimetabolites as a therapeutic strategy. [PDF]

Front Microbiol
Tashie W, de Koning HP, Duah-Quashie NO, Quashie NB.   +3 more
europepmc   +1 more source

Structure-based insights into the ligand specificity tuning of 2'-dG-III riboswitch. [PDF]

Nucleic Acids Res
Shen X, Li H, Xu X, Song Q, Tai X, He M, Ren A.   +6 more
europepmc   +1 more source

G-quadruplexes self-assembled from nucleotide monomers as stable prepolymer scaffolds in aqueous environments. [PDF]

Sci Rep
Eiby SHJ, Catley TE, Gamill MC, Pyne ALB, Hassenkam T.   +4 more
europepmc   +1 more source

Integrative Phosphoproteomic Profiling Reveals Stage‐Specific Signalling and Metabolism in Equine Melanocytic Neoplasm

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Equine melanocytic neoplasms (EMN) are aggressive tumours characterised by high metastatic potential and limited therapeutic options available. However, the molecular mechanisms underlying their progression remain poorly understood. This study therefore presents the integrative phosphoproteomic analysis of EMN tissue, with the aim of ...
Paitoon Srimontri, Amornthep Kingkaw, Nawarus Prapaiwan, Rangsima Sujittosakul, Nichapat Iamkaewprasert, Jiraschaya Piputwat, Puetta Isama‐al, Thanutchanok Munkongdee, Thanapon Chotikaprakal, Petchpailin Yanyongsirikarn, Narumon Phaonakrop, Sittiruk Roytrakul, Wanwipa Vongsangnak, Parichart Tesena   +13 more
wiley   +1 more source

DNA damage reflected in the evolution of G-runs in genomes. [PDF]

Vavilovskii Zhurnal Genet Selektsii
Grin IR, Zharkov DO.
europepmc   +1 more source

A multi‐omics investigation of sarcopenia and frailty: Integrating genomic, epigenomic and telomere length data

Experimental Physiology, EarlyView.
Abstract Sarcopenia and frailty are complex geriatric syndromes influenced by a combination of genetic and environmental factors. Recent studies suggest that specific genetic variants, DNA methylation patterns and shortened telomeres are associated with age‐related diseases and might contribute to the development of both sarcopenia and frailty. In this
Valentina Ginevičienė, Erinija Pranckevičienė, Alina Urnikytė, Laura Jurkūnaitė, Kristijona Gutauskaitė, Rūta Dadelienė, Justina Kilaitė, Ieva Eglė Jamontaitė, Asta Mastavičiūtė, Ildus I. Ahmetov, Vidmantas Alekna   +10 more
wiley   +1 more source

Mutagenic Potentials of DNA Interstrand Cross-Links Induced by 7,8-Dihydro-8-Oxoadenine. [PDF]

Molecules
Schmaltz LF, Rodriguez N, Lee S.
europepmc   +1 more source

Acute capillary blood DNA methylation responses to swimming exercise in high‐performance male and female swimmers

Experimental Physiology, EarlyView.
Abstract Epigenetic markers, particularly DNA methylation, are promising tools for monitoring athlete health and training due to their role in cellular regulation, exercise responsiveness and molecular stability. However, exercise‐induced epigenetic changes in peripheral blood in trained individuals remain unexplored.
C. D. Goldsmith, N. G. Lawler, D. B. Pyne, M. Kozlovskaia, K. McGibbon, L. J. G. Mitchell, A. D. Govus   +6 more
wiley   +1 more source