Results 281 to 290 of about 99,476 (367)

Cadherin‐6 controls neuronal migration during mouse neocortical development via an integrin‐mediated pathway

open access: yesThe FEBS Journal, EarlyView.
Neuronal migration plays essential roles in the establishment of mammalian brains, and its impairment causes severe developmental abnormalities and behavioral and cognitive deficits. Here, we report that cadherin‐6 (CDH6), an unusual cadherin molecule containing an RGD integrin‐binding motif in the first extracellular domain, controls the motility of ...
Yuki Hirota   +7 more
wiley   +1 more source

Flagellins as Vaccine Adjuvants and Cancer Immunotherapy: Recent Advances and Future Prospects

open access: yesImmunology, EarlyView.
The figure depicts the role of flagellin in immune cells. Flagellin interacts with TLR5, resulting in the formation of homodimers and the recruitment of MyD88, which activates the IκB and MAPK signalling pathways. This results in the activation of NF‐κB and AP‐1, producing TNF‐α, IL‐6, IL‐8, and IL‐12.
Asma Talukder   +4 more
wiley   +1 more source

Analysis of quadruplex propensity of aptamer sequences. [PDF]

open access: yesNucleic Acids Res
Cucchiarini A   +3 more
europepmc   +1 more source

A Recursive Model Approach to Include Epigenetic Effects in Genetic Evaluations Using Simulated DNA Methylation Effects

open access: yesJournal of Animal Breeding and Genetics, EarlyView.
ABSTRACT The advancement of epigenetics has highlighted DNA methylation as an intermediate‐omic influencing gene regulation and phenotypic expression. With emerging technologies enabling the large‐scale and affordable capture of methylation data, there is growing interest in integrating this information into genetic evaluation models for animal ...
Adrián López‐Catalina   +3 more
wiley   +1 more source

Integrative morphometric and molecular analyses reveal possible genetic contamination of silver catfish populations of the genus Rhamdia in Neotropical River basins

open access: yesJournal of Fish Biology, EarlyView.
Abstract Rhamdia quelen, Rhamdia branneri and Rhamdia voulezi are morphologically similar species that, until recently, were considered synonymous. Although R. quelen has wide distribution in the Neotropical region, R. branneri and R. voulezi are sympatric and endemic species of the Iguaçu River basin.
Thaís Souto Bignotto   +4 more
wiley   +1 more source

Late blight pathogen targets host Rab‐G3 GTPases with an atypical GTPase‐activating protein

open access: yesJournal of Integrative Plant Biology, EarlyView.
The Phytophthora infestans RXLR effector Pi17063 functions as an atypical GTPase‐activating protein of host positive immune regulators, specifically the small GTPase NbRab‐G3. Pi17063 promotes the relocalization of NbRab‐G3 proteins to the cytoplasm, where they are inactive, disrupting the balance of the NbRab‐G3 switch and thus leading to enhanced ...
Song Liu   +13 more
wiley   +1 more source

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