Results 31 to 40 of about 474 (133)

The advantage of channeling nucleotides for very processive functions [version 1; referees: 3 approved]

F1000Research, 2017
Nucleoside triphosphate (NTP)s, like ATP (adenosine 5’-triphosphate) and GTP (guanosine 5’-triphosphate), have long been considered sufficiently concentrated and diffusible to fuel all cellular ATPases (adenosine triphosphatases) and GTPases (guanosine ...
Diana Zala, Uwe Schlattner, Thomas Desvignes, Julien Bobe, Aurélien Roux, Philippe Chavrier, Mathieu Boissan   +6 more
doaj   +1 more source

Methods for Controlling Small GTPase Activity

ChemBioChem, EarlyView.
This concept highlights recent and emerging methods for controlling small GTPase activity, encompassing both small‐molecule‐based approaches and protein engineering strategies. The use of these approaches to advance the understanding of small GTPase function, current limitations, and future outlook is discussed.
Benjamin Faulkner, Yuchen He, Daniel Sitrin, Cliff I. Stains   +3 more
wiley   +1 more source

AMP-Activated Protein Kinase Activation by 5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) Inhibits Palmitate-Induced Endothelial Cell Apoptosis Through Reactive Oxygen Species Suppression

Journal of Pharmacological Sciences, 2008
AMP-activated protein kinase (AMPK) activation has an antiapoptotic effect in endothelial cells, but the mechanisms involved remain unclear. Here, we investigated whether AMPK activation could inhibit palmitate-induced apoptosis through suppression of ...
Ji-Eun Kim, Yong-Woon Kim, In Kyu Lee, Jong-Yeon Kim, Young Jin Kang, So-Young Park   +5 more
doaj  

Innovative Cyclic Nucleotides – Nucleoside 2′,3′‐Seven‐Membered Cyclic Diphosphonate Derivatives. Theoretical Feasibility, Synthesis, and Properties

Chemistry – A European Journal, EarlyView.
First report on 7‐membered cyclic nucleotides, 2',3'‐cNTDPs, obtained from all‐natural free ribonucleosides in robust, step‐economic synthesis involving instantaneous and regio‐selective reaction. DFT calculations confirmed the feasibility of 7‐membered cyclic nucleotide formation and deciphered the basis for regioselectivity.
Sveta Liberman, Lea Bobot, Hadar T Ben Daniel, Dan T Major, Bilha Fischer   +4 more
wiley   +1 more source

Sports Participation Promotes Beneficial Adaptations in the Erythrocyte Guanylate Nucleotide Pool in Male Athletes Aged 20–90 Years

Clinical Interventions in Aging, 2023
Barbara Pospieszna,1 Krzysztof Kusy,1 Ewa Maria Slominska,2 Monika Ciekot-Sołtysiak,1 Jacek Zieliński1 1Department of Athletics, Strength and Conditioning, Poznan University of Physical Education, Poznan, Poland; 2Department of Biochemistry,
Pospieszna B, Kusy K, Slominska EM, Ciekot-Sołtysiak M, Zieliński J   +4 more
doaj  

The advantage of channeling nucleotides for very processive functions [version 2; referees: 3 approved]

F1000Research, 2017
Nucleoside triphosphate (NTP)s, like ATP (adenosine 5’-triphosphate) and GTP (guanosine 5’-triphosphate), have long been considered sufficiently concentrated and diffusible to fuel all cellular ATPases (adenosine triphosphatases) and GTPases (guanosine ...
Diana Zala, Uwe Schlattner, Thomas Desvignes, Julien Bobe, Aurélien Roux, Philippe Chavrier, Mathieu Boissan   +6 more
doaj   +1 more source

ARC Expands the DAAM1 Microexon‐Mediated Actin–RHOA/ROCK Interplay

Cytoskeleton, EarlyView.
ABSTRACT Actin cytoskeleton and its dynamics play a crucial role in synaptic function, influencing dendritic spines' structural and functional plasticity. Recent findings unveiled the significance of alternative splicing of a neural‐specific microexon in DAAM1 in modulating actin's role in synaptic processes.
Patryk Poliński, Marta Miret Cuesta, Manuel Irimia   +2 more
wiley   +1 more source

Angiogenesis as a Therapeutic Target of (Poly)phenols: Tackling Cancer and Vascular‐Related Complications

Molecular Nutrition &Food Research, EarlyView.
(Poly)phenols constitute a source of natural therapeutic molecules capable of targeting angiogenesis in different scenarios. This review summarizes the current evidence of the role of (poly)phenols in modulating angiogenesis. The reader can find a compilation of preclinical and human investigations describing pro‐ and anti‐angiogenic effects of these ...
María Ángeles Ávila‐Gálvez, Antonio Vico‐Padilla, Claus Schneider, Juan Carlos Espín, Antonio González‐Sarrías, Juan Antonio Giménez‐Bastida   +5 more
wiley   +1 more source

Engineering ascorbic acid biosynthetic pathway in Arabidopsis leaves by single and double gene transformation

Biologia Plantarum, 2012
Six genes, which encode enzymes involved in ascorbic acid (AsA) biosynthesis, including guanosine diphosphate (GDP)-mannose pyrophosphorylase (GMP), GDP-mannose-3',5'-epimerase (GME), GDP-galactose guanylyltransferase (GGT), L-galactose-1-phosphate ...
Y. Zhou, Q. C. Tao, Z. N. Wang, R. Fan, Y. Li, X. F. Sun, K. X. Tang   +6 more
doaj   +1 more source

Repurposing Small Molecules to Target PPAR-γ as New Therapies for Peripheral Nerve Injuries

Biomolecules, 2021
The slow rate of neuronal regeneration that follows peripheral nerve repair results in poor recovery, particularly where reinnervation of muscles is delayed, leading to atrophy and permanent loss of function.
Melissa L. D. Rayner, Jess Healy, James B. Phillips   +2 more
doaj   +1 more source