Guanosine Tetraphosphate Has a Similar Affinity for Each of Its Two Binding Sites on Escherichia coli RNA Polymerase [PDF]
Frontiers in Microbiology, 2020 During nutrient deprivation, the bacterial cell undergoes a stress response known as the stringent response. This response is characterized by induction of the nucleotide derivative guanosine tetraphosphate (ppGpp) that dramatically modulates the cell’s ...
Angela R. Myers +3 more
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A guanosine tetraphosphate (ppGpp) mediated brake on photosynthesis is required for acclimation to nitrogen limitation in Arabidopsis [PDF]
eLife, 2022 Guanosine pentaphosphate and tetraphosphate (together referred to as ppGpp) are hyperphosphorylated nucleotides found in bacteria and the chloroplasts of plants and algae.
Shanna Romand +12 more
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Persistence Increases in the Absence of the Alarmone Guanosine Tetraphosphate by Reducing Cell Growth. [PDF]
Sci Rep, 2016 AbstractMost bacterial cells are stressed and as a result, some become tolerant to antibiotics by entering a dormant state known as persistence. The key intracellular metabolite that has been linked to this persister state is guanosine tetraphosphate (ppGpp), the alarmone that was first linked to nutrient stress.
Chowdhury N, Kwan BW, Wood TK.
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An interplay among FIS, H-NS and guanosine tetraphosphate modulates transcription of the Escherichia coli cspA gene under physiological growth conditions [PDF]
Frontiers in Molecular Biosciences, 2016 CspA, the most characterized member of the csp gene family of Escherichia coli, is highly expressed not only in response to cold stress, but also during the early phase of growth at 37°C.
Anna eBrandi +3 more
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Polyphosphate, cyclic AMP, guanosine tetraphosphate, and c-di-GMP reduce in vitro Lon activity. [PDF]
Bioengineered, 2014 Lon protease is conserved from bacteria to humans and regulates cellular processes by degrading different classes of proteins including antitoxins, transcriptional activators, unfolded proteins, and free ribosomal proteins. Since we found that Lon has several putative cyclic diguanylate (c-di-GMP) binding sites and since Lon binds polyphosphate (polyP)
Osbourne DO +3 more
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Conditions that trigger guanosine tetraphosphate accumulation in Caulobacter crescentus [PDF]
Journal of Bacteriology, 1981 Caulobacter crescentus accumulated guanosine tetraphosphate in response to nitrogen starvation but not in response to amino acid starvation. Nitrogen starvation also acted specifically to inhibit certain transitions in the C. crescentus life cycle, and guanosine tetraphosphate may act as an intracellular regulator of cell cycle events.
Teresa A. Chiaverotti +3 more
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The Elongation Factor Tu · Guanosine Tetraphosphate Complex [PDF]
European Journal of Biochemistry, 1981 The elongation factor Tu (EF‐Tu) isolated from Escherichia coli cells that have undergone the stringent response is predominantly complexed with guanosine 5′‐diphosphate 3′‐diphosphate. This complex can be separated by anion‐exchange chromatography from EF‐Tu · GDP‐ Unlike EF‐Tu complexed with guanosine 5′‐triphosphate 3′‐diphosphate, the complex with ...
Alfred Pingoud, W. Block
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Metabolism of Guanosine Tetraphosphate in Escherichia coli [PDF]
European Journal of Biochemistry, 1972 In rel+ strains of Escherichia coli guanosine 2′(3′)‐diphosphate‐5′‐diphosphate (ppGpp) was found to accumulate (a) during amino acid starvation of an auxotrophic strain, (b) during heating to the non‐permissive temperature of a valSts strain, (c) during heating of a wild‐type strain to temperatures above 46°C and (d) during treatment with trimethoprim
Elsebet Lund, Niels Ole Kjeldgaard
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Guanosine tetraphosphate (ppGpp) is a new player in Brassica napus L. seed development
Food Chemistry, 2023 Rapeseed oil, constituting 12% of global vegetable oil production, is susceptible to quality degradation due to stress-induced incomplete seed degreening, fatty acid oxidation, or poor nutrient accumulation. We hypothesise that the hyperphosphorylated nucleotide alarmone ppGpp (guanosine tetraphosphate), acts as a pivotal regulator of these processes ...
Sena Turkan +9 more
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Variation in guanosine 5' ,3'-tetraphosphate levels in Chromatium [PDF]
Journal of Bacteriology, 1977 Chromatium produces guanosine 5' ,3'-tetraphosphate, but there appears to be no correlation between guanosine 5' ,3'-tetraphosphate concentration and the inability of the organism to grow in certain light-dark regimes.
G Klaussmann, Margaret L. Miović
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