Results 91 to 100 of about 6,159 (212)

The contribution of mRNA targeting to spatial protein localization in bacteria

The FEBS Journal, Volume 291, Issue 21, Page 4639-4659, November 2024.
mRNA‐based targeting serves as a back‐up strategy for the canonical signal sequence‐based protein targeting in bacteria. While signal sequence‐based targeting depends on dedicated protein‐targeting factors, mRNAs encoding inner membrane proteins can bind directly to protein translocases.
Wenkang Shang, Elisabeth Lichtenberg, Andreea Mihaela Mlesnita, Annegret Wilde, Hans‐Georg Koch   +4 more
wiley   +1 more source

ppGpp Controlled by the Gac/Rsm Regulatory Pathway Sustains Biocontrol Activity in Pseudomonas fluorescens CHA0

Molecular Plant-Microbe Interactions, 2012
In Pseudomonas fluorescens CHA0 and other fluorescent pseudomonads, the Gac/Rsm signal transduction pathway is instrumental for secondary metabolism and biocontrol of root pathogens via the expression of regulatory small RNAs (sRNAs).
Kasumi Takeuchi, Kosumi Yamada, Dieter Haas   +2 more
doaj   +1 more source

The stringent response regulator (p) ppGpp mediates virulence gene expression and survival in Erwinia amylovora

BMC Genomics, 2020
Background The nucleotide second messengers, i.e., guanosine tetraphosphate and pentaphosphate [collectively referred to as (p) ppGpp], trigger the stringent response under nutrient starvation conditions and play an essential role in virulence in the ...
Ho-wen Yang, Menghao Yu, Jae Hoon Lee, Tiyakhon Chatnaparat, Youfu Zhao   +4 more
doaj   +1 more source

P2Y receptors in the mammalian nervous system: pharmacology, ligands and therapeutic potential [PDF]

, 2012
P2Y receptors for extracellular nucleotides are coupled to activation of a variety of G proteins and stimulate diverse intracellular signaling pathways that regulate functions of cell types that comprise the central nervous system (CNS).
Erb, Laurie, Seye, Cheik I., Weisman, Gary A., Woods, Lucas T.   +3 more
core   +1 more source

Antimicrobial efficacy of DJK‐5 peptide in combination with EDTA against biofilms in dentinal tubules: Primary irrigation, recovery and re‐irrigation

International Endodontic Journal, Volume 57, Issue 9, Page 1343-1359, September 2024.
Abstract Aim To investigate the dynamic recovery of biofilms within dentinal tubules after primary irrigation with different protocols, and to evaluate the efficacy of various re‐irrigation protocols on recovered biofilm, considering factors such as smear layer, nutrient conditions, and primary irrigants.
Mohamed Amhmed, He Liu, Lari Häkkinen, Markus Haapasalo, Ya Shen   +4 more
wiley   +1 more source

Evolution of a genome-encoded bias in amino acid biosynthetic pathways is a potential indicator of amino acid dynamics in the environment. [PDF]

, 2014
Overcoming the stress of starvation is one of an organism's most challenging phenotypic responses. Those organisms that frequently survive the challenge, by virtue of their fitness, will have evolved genomes that are shaped by their specific environments.
Fasani, Rick A, Savageau, Michael A
core   +1 more source

Synthesis and turnover of basal level guanosine tetraphosphate in Escherichia coli.

Journal of Biological Chemistry, 1975
Cultures of escherichia coli growing exponentially in Trisacetate medium were subjected to nutritional shift-up and the pool size of guanosine 5'-3'-diphosphate-3'diphosphate (ppGpp) as well as the rates of protein synthesis and net RNA synthesis were determined.
J D, Friesen, N P, Fiil, K, von Meyenburg   +2 more
openaire   +2 more sources

Broadening the Substrate Scope of a Polyphosphate Kinase for Canonical and Non‐Canonical Nucleotides

ChemCatChem, Volume 16, Issue 15, August 12, 2024.
In this study, we investigate the substrate spectrum of a polyphosphate kinase for the conversion of non‐canonical nucleotides. Guided by the structure, we created an enzyme variant with enhanced substrate scope for a broad variety of canonical and non‐canonical purine nucleotides. Abstract Polyphosphate kinases (PPKs) are valuable biocatalysts for ATP
Toni Querengässer, Jessica Wenzlaff, Christoph Loderer   +2 more
wiley   +1 more source

Intricate Crosstalk Between Lipopolysaccharide, Phospholipid and Fatty Acid Metabolism in Escherichia coli Modulates Proteolysis of LpxC

Frontiers in Microbiology, 2019
Lipopolysaccharides (LPS) in the outer membrane of Gram-negative bacteria provide the first line of defense against antibiotics and other harmful compounds. LPS biosynthesis critically depends on LpxC catalyzing the first committed enzyme in this process.
Nikolas Thomanek, Jan Arends, Claudia Lindemann, Katalin Barkovits, Helmut E. Meyer, Helmut E. Meyer, Katrin Marcus, Franz Narberhaus   +7 more
doaj   +1 more source

Versatile enzymatic system for the production of guanosine polyphosphates [PDF]

, 2010
Posters - ED02 Signalling and systems biology: abstract no. ED02/20During periods of environmental stress, bacteria synthesize guanosine tetraphosphate (ppGpp, magic spot I) and guanosine pentaphosphate (pppGpp, magic spot II) in a process known as the ...
Choi, MMY, Wang, Y, Watt, RM
core