Results 101 to 110 of about 6,159 (212)

Effects of (p)ppGpp on the progression of the cell cycle of Caulobacter crescentus. [PDF]

, 2014
Bacteria must control the progression of their cell cycle in response to nutrient availability. This regulation can be mediated by guanosine tetra- or pentaphosphate [(p)ppGpp], which are synthesized by enzymes of the RelA/SpoT homologue (Rsh) family ...
Collier, J., Gonzalez, D.
core   +1 more source

Phages produce persisters

Microbial Biotechnology, Volume 17, Issue 8, August 2024.
Bacterial infections are predicted to be the main cause of death by 2050, and persister cells often form during periods of lethal stress. Here, we show phage infections generate persister cells, and these persisters may undermine phage therapy. Abstract Arguably, the greatest threat to bacteria is phages.
Laura Fernández‐García, Joy Kirigo, Daniel Huelgas‐Méndez, Michael J. Benedik, María Tomás, Rodolfo García‐Contreras, Thomas K. Wood   +6 more
wiley   +1 more source

Ribosomal dormancy at the nexus of ribosome homeostasis and protein synthesis

BioEssays, Volume 46, Issue 7, July 2024.
Both prokaryotes and eukaryotes possess multiple forms of dormant ribosomes under unfavorable conditions. Dormancy factors act as translation repressors by occupying functionally crucial ribosomal sites. Dormancy factors protect the ribosomes from the degradation pathways.
Saloni Koli, Sunil Shetty
wiley   +1 more source

Harnessing antimicrobial peptides in endodontics

International Endodontic Journal, Volume 57, Issue 7, Page 815-840, July 2024.
Abstract Endodontic therapy includes various procedures such as vital pulp therapy, root canal treatment and retreatment, surgical endodontic treatment and regenerative endodontic procedures. Disinfection and tissue repair are crucial for the success of these therapies, necessitating the development of therapeutics that can effectively target ...
Xinzi Kong, Vijetha Vishwanath, Prasanna Neelakantan, Zhou Ye   +3 more
wiley   +1 more source

Activation of the Listeria monocytogenes Virulence Program by a Reducing Environment. [PDF]

, 2017
Upon entry into the host cell cytosol, the facultative intracellular pathogen Listeria monocytogenes coordinates the expression of numerous essential virulence factors by allosteric binding of glutathione (GSH) to the Crp-Fnr family transcriptional ...
Aaron T. Whiteley, Bret N. Peterson, Daniel A. Portnoy, Jeff F. Miller, Jonathan L. Portman, Samuel B. Dubensky   +5 more
core   +2 more sources

The activation of Chlamydomonas reinhardtii alpha amylase 2 by glutamine requires its N‐terminal aspartate kinase–chorismate mutase–tyrA (ACT) domain

Plant Direct, Volume 8, Issue 6, June 2024.
Abstract The coordination of assimilation pathways for all the elements that make up cellular components is a vital task for every organism. Integrating the assimilation and use of carbon (C) and nitrogen (N) is of particular importance because of the high cellular abundance of these elements.
Lisa Scholtysek, Ansgar Poetsch, Eckhard Hofmann, Anja Hemschemeier   +3 more
wiley   +1 more source

Intracanal microbiome profiles of two apical periodontitis cases in one patient: A comparison with saliva and plaque profiles

Clinical and Experimental Dental Research, Volume 10, Issue 2, April 2024.
Abstract Objectives To determine the characteristics of the endodontic microbiome. Material and Methods Saliva, plaque, and infected root canal wall dentin of two teeth suffering from apical periodontitis were harvested from a 58‐year‐old man. Bacterial DNA was extracted from each sample, and 16S rRNA gene analysis targeting the V3–V4 region was ...
Keiko Yamaki, Toru Tamahara, Jumpei Washio, Takuichi Sato, Ritsuko Shimizu, Satoru Yamada   +5 more
wiley   +1 more source

Exploring bias in platelet P2Y1 signalling: Host defence versus haemostasis

British Journal of Pharmacology, Volume 181, Issue 4, Page 580-592, February 2024.
Abstract Platelets are necessary for maintaining haemostasis. Separately, platelets are important for the propagation of inflammation during the host immune response against infection. The activation of platelets also causes inappropriate inflammation in various disease pathologies, often in the absence of changes to haemostasis. The separate functions
Dingxin Pan, Graham Ladds, Khondaker Miraz Rahman, Simon C. Pitchford   +3 more
wiley   +1 more source

Molecular regulation of virulence in Legionella pneumophila

Molecular Microbiology, Volume 121, Issue 2, Page 167-195, February 2024.
Enabled by the Type IV Dot/Icm secretion system, the bacterial parasite Legionella pneumophila is evolutionarily adapted to dwell intracellularly in a multitude of eukaryotic hosts including humans. This review is focused on the regulatory mechanisms that govern the switch from bacterial replicative forms to environmentally resilient forms, in response
Christopher I. Graham, Teassa L. MacMartin, Teresa R. de Kievit, Ann Karen C. Brassinga   +3 more
wiley   +1 more source

The architecture and ppGpp-dependent expression of the primary transcriptome of Salmonella Typhimurium during invasion gene expression

BMC Genomics, 2012
Background Invasion of intestinal epithelial cells by Salmonella enterica serovar Typhimurium (S. Typhimurium) requires expression of the extracellular virulence gene expression programme (STEX), activation of which is dependent on the signalling ...
Ramachandran Vinoy K, Shearer Neil, Jacob Jobin J, Sharma Cynthia M, Thompson Arthur   +4 more
doaj   +1 more source