Results 31 to 40 of about 4,514 (202)

Functional Characterization of Small Alarmone Synthetase and Small Alarmone Hydrolase Proteins from Treponema denticola

Microbiology Spectrum, 2023
The stringent response enables bacteria to survive nutrient starvation, antibiotic challenge, and other threats to cellular survival. Two alarmone (magic spot) second messengers, guanosine pentaphosphate (pppGpp) and guanosine tetraphosphate (ppGpp ...
Miao Wang, Nga-Yeung Tang, Shujie Xie, Rory M. Watt   +3 more
doaj   +1 more source

Mutating both relA and spoT of enteropathogenic Escherichia coli E2348/69 attenuates its virulence and induces interleukin 6 in vivo

Frontiers in Microbiology, 2023
Here, we report for the first time that disrupting both relA and spoT genes in enteropathogenic Escherichia coli E2348/69 can attenuate its virulence and significantly induce interleukin 6 (IL-6) in vivo.
Jun Bong Lee, Se Kye Kim, Dalmuri Han, Jang Won Yoon   +3 more
doaj   +1 more source

Emerging and divergent roles of pyrophosphorylated nucleotides in bacterial physiology and pathogenesis.

PLoS Pathogens, 2021
Bacteria inhabit diverse environmental niches and consequently must modulate their metabolism to adapt to stress. The nucleotide second messengers guanosine tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp) (collectively referred to as (p ...
N Y Elizabeth Chau, Shehryar Ahmad, John C Whitney, Brian K Coombes   +3 more
doaj   +1 more source

Identification of a RelA/SpoT Homolog and Its Possible Role in the Accumulation of Astaxanthin in Haematococcus pluvialis

Frontiers in Plant Science, 2022
A RelA/SpoT homolog, HpRSH, was identified in Haematococcus pluvialis. HpRSH was found to catalyze Mg2+-dependent guanosine tetraphosphate (ppGpp) synthesis and Mn2+-dependent ppGpp hydrolysis, respectively.
Hui Jin, Hui Jin, Yong Min Lao, Jin Zhou, Zhong Hua Cai   +4 more
doaj   +1 more source

The two PPX-GppA homologues from Mycobacterium tuberculosis have distinct biochemical activities. [PDF]

PLoS ONE, 2012
Inorganic polyphosphate (poly-P), guanosine pentaphosphate (pppGpp) and guanosine tetraphosphate (ppGpp) are ubiquitous in bacteria. These molecules play a variety of important physiological roles associated with stress resistance, persistence, and ...
Mei Y Choi, Ying Wang, Leo L Y Wong, Bing-Tai Lu, Wen-Yang Chen, Jian-Dong Huang, Julian A Tanner, Rory M Watt   +7 more
doaj   +1 more source

Forming and waking dormant cells: The ppGpp ribosome dimerization persister model

Biofilm, 2020
Procaryotes starve and face myriad stresses. The bulk population actively resists the stress, but a small population weathers the stress by entering a resting stage known as persistence.
Thomas K. Wood, Sooyeon Song
doaj   +1 more source

Recent functional insights into the magic role of (p)ppGpp in growth control

Computational and Structural Biotechnology Journal, 2023
Rapid growth and survival are two key traits that enable bacterial cells to thrive in their natural habitat. The guanosine tetraphosphate and pentaphosphate [(p)ppGpp], also known as “magic spot”, is a key second messenger inside bacterial cells as well ...
Haoyan Mu, Fei Han, Qian Wang, Yanling Wang, Xiongfeng Dai, Manlu Zhu   +5 more
doaj   +1 more source

Salmonella Reprograms Nucleotide Metabolism in Its Adaptation to Nitrosative Stress

mBio, 2018
The adaptations that protect pathogenic microorganisms against the cytotoxicity of nitric oxide (NO) engendered in the immune response are incompletely understood.
Liam F. Fitzsimmons, Lin Liu, Ju-Sim Kim, Jessica Jones-Carson, Andrés Vázquez-Torres   +4 more
doaj   +1 more source

ppGpp Controls Global Gene Expression in Light and in Darkness in S. elongatus

Cell Reports, 2017
The bacterial and plant stringent response involves production of the signaling molecules guanosine tetraphosphate and guanosine pentaphosphate ((p)ppGpp), leading to global reorganization of gene expression.
Anna M. Puszynska, Erin K. O’Shea
doaj   +1 more source

Regulation of ytfK by cAMP-CRP Contributes to SpoT-Dependent Accumulation of (p)ppGpp in Response to Carbon Starvation YtfK Responds to Glucose Exhaustion

Frontiers in Microbiology, 2021
Guanosine penta- or tetraphosphate (known as (p)ppGpp) serves as second messenger to respond to nutrient downshift and other environmental stresses, a phenomenon called stringent response.
Laura Meyer, Elsa Germain, Etienne Maisonneuve   +2 more
doaj   +1 more source