Results 41 to 50 of about 4,514 (202)
Regulation of Phospholipid Synthesis in Escherichia coli by Guanosine Tetraphosphate [PDF]
Journal of Bacteriology, 1973 Phospholipid synthesis has been reported to be subject to stringent control in Escherichia coli . We present evidence that demonstrates a strict correlation between guanosine tetraphosphate accumulation and inhibition of phospholipid synthesis.
J P, Merlie, L I, Pizer
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Theoretical perspective on synthetic man‐made life: Learning from the origin of life
Quantitative Biology, Volume 11, Issue 4, Page 376-394, December 2023., 2023 Abstract Creating a man‐made life in the laboratory is one of life science’s most intriguing yet challenging problems. Advances in synthetic biology and related theories, particularly those related to the origin of life, have laid the groundwork for further exploration and understanding in this field of artificial life or man‐made life.
Lu Peng +11 more
wiley +1 more source
Bio-Protocol, 2016 The stringent response in bacteria is a stress response that is mediated by the signaling molecules guanosine tetraphosphate and pentaphosphate [(p)ppGpp], alarmones that are also directly related to virulence. Therefore, determination of (p)ppGpp levels
Smitha Sivapragasam, Anne Grove
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The Borrelia burgdorferi RelA/SpoT Homolog and Stringent Response Regulate Survival in the Tick Vector and Global Gene Expression during Starvation. [PDF]
PLoS Pathogens, 2015 As the Lyme disease bacterium Borrelia burgdorferi traverses its enzootic cycle, alternating between a tick vector and a vertebrate host, the spirochete must adapt and persist in the tick midgut under prolonged nutrient stress between blood meals.
Dan Drecktrah +5 more
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Promoter domain mediates guanosine tetraphosphate activation of the histidine operon. [PDF]
Proceedings of the National Academy of Sciences, 1986 We have analyzed the effects of the "alarmone" guanosine 5'-diphosphate 3'-diphosphate (ppGpp) on regulation of the Salmonella typhimurium histidine operon in vitro. Expression of the wild-type promoter, measured in a DNA-dependent transcription-translation system, was strongly dependent on ppGpp; addition of ppGpp stimulated his expression 22-fold ...
D L, Riggs +3 more
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Communications Biology, 2023 The cyanobacterium Synechococcus elongatus PCC 7942 accumulates alarmone guanosine tetraphosphate (ppGpp) under stress conditions, such as darkness. A previous study observed that artificial ppGpp accumulation under photosynthetic conditions led to the ...
Ryota Hidese +8 more
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npj Systems Biology and Applications, 2022 Growth and environmental responses are essential for living organisms to survive and adapt to constantly changing environments. In order to simulate new conditions and capture dynamic responses to environmental shifts in a developing whole-cell model of ...
Travis A. Ahn-Horst +4 more
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SpoT Induces Intracellular
mBio, 2020 Guanosine tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp), together named (p)ppGpp, regulate diverse aspects of Salmonella pathogenesis, including synthesis of nutrients, resistance to inflammatory mediators, and expression of secretion ...
Liam F. Fitzsimmons +8 more
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EBioMedicine, 2016 Cutaneous abscess infections are difficult to treat with current therapies and alternatives to conventional antibiotics are needed. Understanding the regulatory mechanisms that govern abscess pathology should reveal therapeutic interventions for these ...
Sarah C. Mansour +7 more
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relA enhances the adherence of enteropathogenic Escherichia coli. [PDF]
PLoS ONE, 2014 Enteropathogenic Escherichia coli (EPEC) is a known causative agent of diarrhea in children. In the process of colonization of the small intestine, EPEC synthesizes two types of adhesins, the bundle-forming pilus (BFP) and intimin.
Beny Spira +2 more
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