Results 61 to 70 of about 4,514 (202)

Nanomedicine Strategies Against Biofilm‐Associated Infections: Advances, Challenges, and Translational Barriers

MicrobiologyOpen, Volume 15, Issue 1, February 2026.
Explore the key challenges and limitations in nanomedicine for biofilm treatment, from drug loading efficiency to antimicrobial resistance. ABSTRACT Antimicrobial resistance continues to rise globally, with biofilm‐associated infections intensifying the clinical burden through persistent tolerance to antibiotics and evasion of immune responses ...
Husni Farah, Munthar Kadhim‐Abosaoda, Hayjaa Mohaisen‐Mousa, S. Renuka Jyothi, Priya Priyadarshini‐Nayak, J. Bethanney Janney, Gurjant Singh, Ashish Singh‐Chauhan, Manoj Kumar‐Mishra   +8 more
wiley   +1 more source

Photocaged Dinucleoside Tetraphosphates for Light‐Mediated Activation of 5′ Cap Interactions and Translation In Vitro

ChemistryEurope, Volume 3, Issue 6, November 11, 2025.
Photocaged dinucleoside tetraphosphates can be incorporated into mRNA by T7 RNA polymerase. Subsequent irradiation with light activates 5′ cap interactions and translation. These 5′ cap analogs are useful tools to probe the functions of naturally occurring dinucleoside tetraphosphates and their role in bacteria and mammalian cells.
Cedrik Kühling, Wiebke Teich, Bayram Terzi, Helena Schepers, Sabine Hüwel, Andrea Rentmeister   +5 more
wiley   +1 more source

Advances and Strategies in Enhancing mRNA Cancer Vaccines

Advanced Materials, Volume 37, Issue 42, October 23, 2025.
Messenger RNA (mRNA) vaccines offer a powerful approach for cancer immunotherapy, but their clinical impact remains limited by delivery challenges and suboptimal immune activation. This review discusses key biological barriers and design strategies—including structural optimization, immunomodulation, organ targeting delivery, and advanced nanocarriers ...
Miao Zhang, Shengqi Chen, Haijun Hu, Yenhui Ong, Qianqian Ni   +4 more
wiley   +1 more source

Induction of the Stringent Response Underlies the Antimicrobial Action of Aliphatic Isothiocyanates

Frontiers in Microbiology, 2021
Bacterial resistance to known antibiotics comprises a serious threat to public health. Propagation of multidrug-resistant pathogenic strains is a reason for undertaking a search for new therapeutic strategies, based on newly developed chemical compounds ...
Dariusz Nowicki, Klaudyna Krause, Patrycja Szamborska, Adrianna Żukowska, Grzegorz M. Cech, Agnieszka Szalewska-Pałasz   +5 more
doaj   +1 more source

The primary transcriptome of Salmonella enterica Serovar Typhimurium and its dependence on ppGpp during late stationary phase. [PDF]

PLoS ONE, 2014
We have used differential RNA-seq (dRNA-seq) to characterise the transcriptomic architecture of S. Typhimurium SL1344, and its dependence on the bacterial alarmone, guanosine tetraphosphate (ppGpp) during late stationary phase, (LSP).
Vinoy K Ramachandran, Neil Shearer, Arthur Thompson   +2 more
doaj   +1 more source

Clavibacter michiganensis Reframed: The Story of How the Genomics Era Made a New Face for an Old Enemy

Molecular Plant Pathology, Volume 26, Issue 5, May 2025.
We provide a historical perspective and an updated overview on the aetiology, epidemiology and management strategies of tomato bacterial canker caused by Clavibacter michiganensis. ABSTRACT Objective Bacterial wilt and canker of tomato caused by the gram‐positive corynebacterial species Clavibacter michiganensis is an economically important disease ...
Ebrahim Osdaghi, Hamid Abachi, Marie‐Agnes Jacques   +2 more
wiley   +1 more source

Exogenous fatty acids inhibit fatty acid synthesis by competing with endogenously generated substrates for phospholipid synthesis in Escherichia coli

FEBS Letters, Volume 599, Issue 5, Page 667-681, March 2025.
Bacteria can absorb external fatty acids to build their membranes. Working in E. coli, we show that external fatty acids inhibit internal fatty acid production through competition for membrane synthesis. This rapid negative feedback helps bacteria conserve resources and preserve membrane properties. We predict similar mechanisms exist in many bacteria.
Stefan Pieter Hendrik van den Berg, Adja Zoumaro‐Djayoon, Flora Yang, Gregory Bokinsky   +3 more
wiley   +1 more source

Adenosine Awakens Metabolism to Enhance Growth-Independent Killing of Tolerant and Persister Bacteria across Multiple Classes of Antibiotics

mBio, 2022
Metabolic and growth arrest are primary drivers of antibiotic tolerance and persistence in clinically diverse bacterial pathogens. We recently showed that adenosine (ADO) suppresses bacterial growth under nutrient-limiting conditions.
David A. Kitzenberg, J. Scott Lee, Krista B. Mills, Ju-Sim Kim, Lin Liu, Andrés Vázquez-Torres, Sean P. Colgan, Daniel J. Kao   +7 more
doaj   +1 more source

The Mysterious World of Non‐Canonical Caps – What We Know and Why We Need New Sequencing Techniques

ChemBioChem, Volume 26, Issue 3, February 1, 2025.
This review describes sophisticated methodologies such as LC–MS that enabled the identification of 5’ non‐canonical RNA caps and also surveys so far developed sequencing methods, evaluating their advantages and disadvantages. It emphasizes the need for developing new, reliable sequencing techniques to identify RNA types with non‐canonical caps enabling
Flaminia Mancini, Hana Cahova
wiley   +1 more source

Distinguishing Crohn’s Disease From Non–Crohn’s Ileitis: A Gut Microbiome–Based Approach

Advanced Gut &Microbiome Research, Volume 2025, Issue 1, 2025.
Background: The differential diagnosis between symptomatic non–Crohn’s ileitis (NCI) and Crohn’s disease (CD) has been a long‐standing dilemma with similar clinical, endoscopic, and histopathology findings. We aimed to conduct a pilot study to compare the fecal microbiome between NCI and CD.
Nalini Raghunathan, Varun Joshi, Dhanush Mekala, Rajendra Patel, Shubhankar Godbole, Rupjyoti Talukdar, Duvvur Nageshwar Reddy, Rupa Banerjee, Jian Wu   +8 more
wiley   +1 more source