The plant Nudix hydrolase family. [PDF]
, 2008 Nudix hydrolases are a family of proteins defined by a conserved amino-acid sequence GX(5)-EX(7)REUXEEXGU, where U is a hydrophobic residue. These enzymes are widely distributed among all classes of organisms and catalyze, with varying degrees of ...
Kraszewska, Elzbieta
core
An HD domain phosphohydrolase active site tailored for oxetanocin-A biosynthesis [PDF]
, 2016 HD domain phosphohydrolase enzymes are characterized by a conserved set of histidine and aspartate residues that coordinate an active site metallocenter. Despite the important roles these enzymes play in nucleotide metabolism and signal transduction, few
Drennan, Catherine L. +4 more
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BMC Neuroscience, 2004 Background Early stages in the excitation cascade of Limulus photoreceptors are mediated by activation of Gq by rhodopsin, generation of inositol-1,4,5-trisphosphate by phospholipase-C and the release of Ca2+.
Lisman John E +2 more
doaj +1 more source
Polyphosphate and associated enzymes as global regulators of stress response and virulence in Campylobacter jejuni [PDF]
, 2016 Campylobacter jejuni (C. jejuni), a Gram-negative microaerophilic bacterium, is a predominant cause of bacterial foodborne gastroenteritis in humans worldwide.
Gangaiah, Dharanesh +3 more
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mSystems, 2020 The bacterial stringent stress response, mediated by the signaling molecule guanosine tetraphosphate, ppGpp, has recently gained attention as being important during normal cellular growth and as a potential new therapeutic target, which warrants detailed
Daniel Pletzer +7 more
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Nucleosided derived antibiotics to fight microbial drug resistance: New utilities for an established class of drugs? [PDF]
, 2016 Novel antibiotics are urgently needed to combat the rise of infections due to drug-resistant microorganisms. Numerous natural nucleosides and their synthetically modified analogues have been reported to have moderate to good antibiotic activity against ...
Ferrari, Valentina +2 more
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Metatranscriptome of human faecal microbial communities in a cohort of adult men [PDF]
, 2018 The gut microbiome is intimately related to human health, but it is not yet known which functional activities are driven by specific microorganisms\u27 ecological configurations or transcription.
Abu-Ali, Galeb S. +11 more
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New perspectives on the molecular mechanisms of stress signalling by the nucleotide guanosine tetraphosphate (ppGpp), an emerging regulator of photosynthesis in plants and algae. [PDF]
New Phytol, 2023 Mehrez M, Romand S, Field B.
europepmc +1 more source
Replication of plasmids derived from Shiga toxinconverting bacteriophages in starved Escherichia coli [PDF]
, 2011 The pathogenicity of Shiga toxin-producing Escherichia coli (STEC) depends on the expression of stx genes that are located on lambdoid prophages. Effective toxin production occurs only after prophage induction, and one may presume that replication of the
Nadratowska-Wesołowska, Beata +4 more
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Structure–activity relationships of dinucleotides: Potent and selective agonists of P2Y receptors [PDF]
, 2005 Dinucleoside polyphosphates act as agonists on purinergic P2Y receptors to mediate a variety of cellular processes. Symmetrical, naturally occurring purine dinucleotides are found in most living cells and their actions are generally known.
A Brevet +31 more
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