Results 111 to 120 of about 264,776 (358)

Computer Algorithms for Automated Detection and Analysis of Local Ca2+ Releases in Spontaneously Beating Cardiac Pacemaker Cells [PDF]

open access: yes, 2017
Local Ca Releases (LCRs) are crucial events involved in cardiac pacemaker cell function. However, specific algorithms for automatic LCR detection and analysis have not been developed in live, spontaneously beating pacemaker cells. Here we measured LCRs using a high-speed 2D-camera in spontaneously contracting sinoatrial (SA) node cells isolated from ...
arxiv   +1 more source

Analytical and Pharmacological Characterization of 1‐(Furan‐2‐Carbonyl)‐LSD (1F‐LSD) and Comparison With 1‐(Thiophene‐2‐Carbonyl)‐LSD (1T‐LSD)

open access: yesDrug Testing and Analysis, EarlyView.
The novel lysergamide 1‐(furan‐2‐carbonyl)‐LSD (1F‐LSD) was analytically characterized. 1F‐LSD showed LSD‐like activity in vivo similar to 1‐(thiophene‐2‐carbonyl)‐LSD (1T‐LSD) used for comparison. Administration studies in mice and LC–MS analysis revealed that 1F‐LSD served as a prodrug.
Simon D. Brandt   +5 more
wiley   +1 more source

Living Labs - An Ethical Challenge for Researchers and Platform Providers [PDF]

open access: yes, 2017
The infamous Facebook emotion contagion experiment is one of the most prominent and best-known online experiments based on the concept of what we here call "living labs". In these kinds of experiments, real-world applications such as social web platforms trigger experimental switches inside their system to present experimental changes to their users ...
arxiv   +1 more source

Patients Are Not Guinea Pigs

open access: yesPlastic and Reconstructive Surgery - Global Open, 2022
Lilit Garibyan, MD, PhD   +1 more
openaire   +3 more sources

Analysis pipeline to quantify uterine gland structural variations

open access: yesDevelopmental Dynamics, EarlyView.
Abstract Background Technical advances in whole tissue imaging and clearing have allowed 3D reconstruction of exocrine uterine glands deep‐seated in the endometrium. However, there are limited gland structure analysis platforms to analyze these imaging data sets. Here, we present a pipeline for segmenting and analyzing uterine gland shape.
Sameed Khan   +4 more
wiley   +1 more source

FUNCTIONAL STATUS OF PROOXIDANT AND ANTIOXIDANT SYSTEMS IN THE LUNGS UNDER EXPERIMENTAL ALLERGIC ALVEOLITIS AND STRESS

open access: yesПраці Наукового товариства імені Шевченка. Медичні науки, 2019
We have analysed the results of the study of alterations in indices of pro-oxidant (conjugated diene and malondialdehyde) and antioxidant (superoxide dismutase, ceruloplasmin, catalase) systems in guinea pigs’lungs in experimental allergic alveolitis in ...
Marta Kovalska
doaj   +1 more source

Evaluation of clinical parameters for detection of early endpoint criteria in guinea pigs experimentally infected with Mycobacterium tuberculosis [PDF]

open access: yes, 2015
Includes bibliographical references.2015 Summer.Tuberculosis (TB) is a global epidemic caused by the bacteria Mycobacterium tuberculosis. Despite extensive research and funding to improve diagnostic and treatment strategies, the emergence of multi drug ...
Williams, Wendy R.
core  

Contesting the crisis narrative: epidemic accounts in Sierra Leone, Tanzania, and Democratic Republic of the Congo

open access: yesDisasters, Volume 47, Issue 1, Page 78-98, January 2023., 2023
Scientists and global commentators watched African countries closely in the early months of the COVID‐19 pandemic, predicting an impending disaster: the virus was projected to overwhelm already weak health systems. These expectations were informed by imaginaries of Africa as an inevitable site of epidemic disaster.
Shelley Lees, Luisa Enria, Myfanwy James
wiley   +1 more source

Photoperiod influences the development and the expression of personality traits and social behaviour in wild cavies (Cavia aperea)

open access: yesEthology, Volume 129, Issue 1, Page 33-46, January 2023., 2023
Seasonal variation in temperature and food abundance strongly influences life history and behaviour. For animals living in non‐tropical regions, seasonal variation can be reliably predicted by photoperiod and be used for plastic adjustments. Here, we tested if maternal behaviour of the precocial cavy (Cavia aperea) responds to photoperiodic cues and ...
Anja Guenther, Fritz Trillmich
wiley   +1 more source

Targeting Connexin 43 in Retinal Astrocytes Promotes Neuronal Survival in Glaucomatous Injury

open access: yesGlia, EarlyView.
Astrocytes play an important role in glaucoma. These cells express Cx43, which can form gap junctions and hemichannels. This study shows that Cx43 deletion in astrocytes provides neuroprotection in glaucoma, possibly through hemichannel activation. ABSTRACT Astrocytes in the retina and optic nerve head play an important role in the pathogenesis of ...
Khulan Batsuuri   +4 more
wiley   +1 more source

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