Gut microbiota–derived short-chain fatty acids and kidney diseases
Drug Design, Development and Therapy, 2017 Lingzhi Li, Liang Ma, Ping Fu Kidney Research Institute, Department of Nephrology, West China Hospital of Sichuan University, Chengdu 610041, China Abstract: Gut microbiota and its metabolites play pivotal roles in host physiology and pathology.
Li L, Ma L, Fu P
doaj +1 more source
A facile polysaccharide hydrogel activates PPARγ via the Gut-Kidney axis to ameliorate chronic kidney disease [PDF]
Journal of NanobiotechnologyChronic Kidney Disease (CKD) features gut microbiota dysbiosis, systemic inflammation, and impaired barrier function. The formation of such a triad of “microbiota-metabolite-barrier” dysregulation underscores the therapeutic potential of a Gut-Kidney ...
Zhuowen Liang +11 more
doaj +2 more sources
Targeting the gut-kidney axis to improve kidney transplantation prognosis: from mechanisms to clinical intervention strategies [PDF]
Renal FailureKidney transplantation is an important treatment for end-stage renal disease, but lifelong immunosuppression is needed to prevent immune rejection, but the immunosuppressive therapy increases the risk of post-transplant complications.
Huanhuan Cao +5 more
doaj +2 more sources
The Gut-Kidney Axis in Urolithiasis: Roles of Gut Microbiota, Metabolites, and Therapeutic Implications [PDF]
Frontiers in MicrobiologyUrolithiasis affects 2–20% of the global population and recurs frequently. Emerging evidence positions the gut–kidney axis as a central driver of stone formation. This review synthesizes epidemiological data, comparative metagenomic analyzes, and mechanistic studies to demonstrate that stone formers exhibit reduced α-diversity, depletion of oxalate ...
Li D, Li Z, Liu W.
exaly +4 more sources
Role of the Gut Microbiota in Children with Kidney Disease
Children, 2023 Disruption of the composition and structure of the gut microbiota, namely dysbiosis, dictates the pathophysiology of kidney diseases. The bidirectional kidney–gut axis is of interest in chronic kidney disease (CKD); the uremic milieu leads to intestinal ...
You-Lin Tain, Chien-Ning Hsu
doaj +2 more sources
Gut Microbiota and Its Role in the Brain-Gut-Kidney Axis in Hypertension
Current Hypertension Reports, 2023 The role of the gut microbiota in modulating blood pressure is increasingly being recognized, currently. The purpose of this review is to summarize recent findings about the mechanisms involved in hypertension with regard to the phenomenon of "gut dysbiosis."Gut dysbiosis, i.e., the imbalance between the gut microbiota and the host, is characterized by
Natalia G. Vallianou +7 more
openaire +4 more sources
The gut–kidney axis in high-altitude hypoxia: pathophysiological mechanisms and the central role of hypoxia inducible factor [PDF]
Annals of MedicineBackground The high-altitude plateau environment, defined by hypobaric hypoxia, poses considerable health risks to human populations. Due to their substantial oxygen requirements, the kidneys are particularly susceptible, as are the intestines, with ...
Peiwen Wu +6 more
doaj +2 more sources
A gut microbiome-kidney-heart axis predictive of future cardiovascular diseases [PDF]
Nature CommunicationsCardiovascular diseases (CVD) remain a major global health challenge. Early markers of disease initiation and progression are urgently needed. We, and others, have previously shown changes in the gut microbiome in association with metabolic and CVD. Here,
Kanta Chechi +74 more
doaj +3 more sources
Exploring the Role of Microbiota-mediated Gut-Kidney Axis in Acute Kidney Injury: Immunomodulation & Therapy [PDF]
Kidney DiseasesBackground: Acute kidney injury (AKI) remains a major clinical problem characterized by high morbidity and an increased risk of progression to chronic kidney disease (CKD). Immune cell infiltration and activation are important features of AKI;
Litong Zhu +6 more
doaj +2 more sources
Urea and impairment of the Gut-Kidney axis in Chronic Kidney Disease.
Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia, 2017 Gut microbiota can be considered a real organ coordinating health and wellness of our body. It is made of more than 100 trillions of microorganisms, thus about 3 times higher than the number of human body cells and more than 150 times than human genes containing 1000 different microbe species.
Di Iorio, Biagio Raffaele +6 more
openaire +3 more sources