Results 91 to 100 of about 852,730 (306)

Gut Microbiome Perturbations Induced by Bacterial Infection Affect Arsenic Biotransformation [PDF]

, 2013
Exposure to arsenic affects large human populations worldwide and has been associated with a long list of human diseases, including skin, bladder, lung, and liver cancers, diabetes, and cardiovascular disorders.
Abo, Ryan, Bodnar, Wanda M., Cable, Peter Hans, Fox, James G, Graffam, Michelle E., Levine, Stuart S., Lu, Kun, Parry, Nicola Maria Anne, Ru, Hongyu, Schlieper, Katherine Ann, Styblo, Miroslav, Swenberg, James A., Tannenbaum, Steven R, Wishnok, John S.   +13 more
core   +2 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Antimicrobial activity and possible mechanisms of juglone against Escherichia coli, Staphylococcus aureus, and Salmonella pullorum

BMC Microbiology
Background Escherichia coli, Staphylococcus aureus, and Salmonella pullorum are significant pathogens that threaten livestock and poultry health. Although antibiotics and synthetic antimicrobial agents can combat these pathogens, antibiotic resistance ...
Lei Wang, Mingxin Qiu, Xuanyue Li, Mengjian Liu, Luyu Li, Yong Chen   +5 more
doaj   +1 more source

Bifidobacterium breve UCC2003 Induces a Distinct Global Transcriptomic Program in Neonatal Murine Intestinal Epithelial Cells

iScience, 2020
Summary: The underlying health-driving mechanisms of Bifidobacterium during early life are not well understood, particularly how this microbiota member may modulate the intestinal barrier via programming of intestinal epithelial cells (IECs).
Raymond Kiu, Agatha Treveil, Lukas C. Harnisch, Shabhonam Caim, Charlotte Leclaire, Douwe van Sinderen, Tamas Korcsmaros, Lindsay J. Hall   +7 more
doaj   +1 more source

Molecular estimation of alteration in intestinal microbial composition in Hashimoto's thyroiditis patients [PDF]

, 2017
The gut microbiota has a crucial effect on human health and physiology. Hypothyroid Hashimoto’s thyroiditis (HT) is an autoimmune disorder manifested with environmental and genetic factors.
Guo, Hui, Hou, Yin Jian, Ishaq, Hafiz Muhammad, Ma, Chaofeng, Mohammad, Imran Shair, Naseem, Zahid, Shahzad, Muhammad, Shi, Peijie, Wu, Xiaokang, Xu, Jiru   +9 more
core   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Gut Microbiome Phenotypes Driven by Host Genetics Affect Arsenic Metabolism [PDF]

, 2013
Large individual differences in susceptibility to arsenic-induced diseases are well-documented and frequently associated with different patterns of arsenic metabolism.
Bodnar, Wanda M., Cable, Peter Hans, Fox, James G., Lu, Kun, Mahbub, Ridwan, Parry, Nicola M. A., Ru, Hongyu, Styblo, Miroslav, Swenberg, James A., Tannenbaum, Steven Robert, Wishnok, John S.   +10 more
core   +3 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Synergistic Effect of Microorganisms and Enzymes on Nutritional Value of Corn Stover and Wheat Straw

Fermentation
In this study, Candida utilis, Lactobacillus plantarum, and non-starch polysaccharide enzymes (cellulase, laccase, β-glucanase, xylanase, and mannanase) were employed to examine the effects of various microorganism–enzyme combinations on the nutritional ...
Binglong Chen, Jiancheng Liu, Mengjian Liu, Huiling Zhang, Xuanyue Li, Congcong Tian, Yong Chen   +6 more
doaj   +1 more source