Results 71 to 80 of about 12,391,803 (296)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Relationship between psychological state and level of activity of extrinsic gut innervation in patients with a functional gut disorder [PDF]

, 2001
Background: Anxiety and depression are known to be associated with alterations in central autonomic activity, and this may manifest as a functional gut disturbance.
H J Mason, Mason, H.J., M A Kamm, Emmanuel, A.V., Kamm, M.A., A V Emmanuel   +5 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Acute Effects of Butyrate on Induced Hyperpermeability and Tight Junction Protein Expression in Human Colonic Tissues

Biomolecules, 2020
Intact intestinal barrier function is essential for maintaining intestinal homeostasis. A dysfunctional intestinal barrier can lead to local and systemic inflammation through translocation of luminal antigens and has been associated with a range of ...
Mathias W. Tabat, Tatiana M. Marques, Malin Markgren, Liza Löfvendahl, Robert J. Brummer, Rebecca Wall   +5 more
doaj   +1 more source

Development of the preterm gut microbiome in twins at risk of necrotising enterocolitis and sepsis [PDF]

, 2013
The preterm gut microbiome is a complex dynamic community influenced by genetic and environmental factors and is implicated in the pathogenesis of necrotising enterocolitis (NEC) and sepsis.
Christopher J Stewart, Berrington, Janet E., Andrew Nelson, Cummings Stephen P., Nelson Andrew, Stewart, Christopher, Janet E Berrington, Marrs, Emma, Stephen P Cummings, Embleton, Nicholas D., Janet E. Berrington (452418), Lanyon Clare, Stewart, Christopher J., Perry John D., Berrington, Janet, Stephen P. Cummings (106316), Cummings, Stephen, Emma C. L. Marrs (452415), Perry, John, Nicholas D. Embleton (177535), Embleton Nicholas D., Berrington Janet E., Nelson, Andrew, Cummings, Stephen P., Christopher J. Stewart (452414), Clare Lanyon (452416), Stewart Christopher J., Embleton, Nicholas, Andrew Nelson (209359), Perry, John D., Emma C L Marrs, John D Perry, Clare Lanyon, Marrs, Emma C.L., Lanyon, Clare, John D. Perry (452417), Nicholas D Embleton, Marrs Emma C. L.   +37 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

An update on the human and animal enteric pathogen Clostridium perfringens

Emerging Microbes and Infections, 2018
Clostridium perfringens, a rapid-growing pathogen known to secrete an arsenal of >20 virulent toxins, has been associated with intestinal diseases in both animals and humans throughout the past century.
Raymond Kiu, Lindsay J. Hall
doaj   +1 more source

Why is epidermal growth factor present in the gut lumen? [PDF]

, 1996
Wright, NA, Playford, RJ
core   +4 more sources

Gut Phageome—An Insight into the Role and Impact of Gut Microbiome and Their Correlation with Mammal Health and Diseases

, 2023
The gut microbiota, including bacteria, archaea, fungi, and viruses, compose a diverse mammalian gut environment and are highly associated with host health. Bacteriophages, the viruses that infect bacteria, are the primary members of the gastrointestinal
Vivian C. H. Wu, Somanshu Sharma, Logan Tom, Yen-Te Liao, Yujie Zhang   +4 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source