Results 51 to 60 of about 12,827,422 (265)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Dietary Carbohydrate Constituents Related to Gut Dysbiosis and Health

, 2020
Recent studies report that microbiota in the human intestine play an important role in host health and that both long- and short-term diets influence gut microbiota.
Ye Seul Seo, Ho-Young Park, Yoonsook Kim, Hye-Bin Lee   +3 more
core   +1 more source

Use of genetically modified bacteria for drug delivery in humans: Revisiting the safety aspect

Scientific Reports, 2017
The use of live, genetically modified bacteria as delivery vehicles for biologics is of considerable interest scientifically and has attracted significant commercial investment.
Udo Wegmann, Ana Lucia Carvalho, Martin Stocks, Simon R. Carding   +3 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The role of the mucin-glycan foraging Ruminococcus gnavus in the communication between the gut and the brain

Gut Microbes, 2022
Ruminococcus gnavus is a prevalent member of the human gut microbiota, which is over-represented in inflammatory bowel disease and neurological disorders. We previously showed that the ability of R.
Erika Coletto, Dimitrios Latousakis, Matthew G. Pontifex, Emmanuelle H. Crost, Laura Vaux, Estella Perez Santamarina, Andrew Goldson, Arlaine Brion, Mohammad K. Hajihosseini, David Vauzour, George M Savva, Nathalie Juge   +11 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Metabolic adaptation to a high-fat diet is associated with a change in the gut microbiota [PDF]

, 2011
Objective The gut microbiota, which is considered a causal factor in metabolic diseases as shown best in animals, is under the dual influence of the host genome and nutritional environment. This study investigated whether the gut microbiota per se, aside
Klopp, Christophe, Amar, Jacques, Aurelie Waget, Baylac, Audrey, Waget, Aurélie, Klopp, Pascale, Theodorou, Vassilia, Elodie Luche, Iacovoni, Jason, Francoise Ouarné, Bouloumié, Anne, Jerome Mariette, Pascale Klopp, Klopp, Christophe,, Bergé, Mathieu, Mariette, Jérôme, J., Klopp, Pascal, Remy Burcelin, Serino, Matteo, Burcelin, Rémy, Valet, Philippe, Roques, Christine, Bouchez, Olivier, Matteo Serino, Mathieu Bergé, Jacques Amar, Claire Cenac, Philippe Valet, Monsan, Pierre, Jerome Lluch, Sandra Gres, Mariette, Jérôme,, Christophe Klopp, Christine Roques, Pierre Monsan, Mariette, Jérôme, Jason Iacovoni, Vassilia Théodorou, Cenac, Claire, Lluch, Jérôme, Audrey Baylac, Gres, Sandra, Ouarné, Françoise, Anne Bouloumié, Luche, Elodie, Olivier Bouchez   +45 more
core   +1 more source

Overweight and obesity are associated with colorectal neoplasia in an Australian outpatient population

Scientific Reports
Colorectal cancer is a major cause of cancer-related deaths within the Australian population. Colonoscopy and polypectomy represent effective forms of prevention.
Rina Kumar, Allison Brown, Satomi Okano, Lisa Simms, Anton Lord, Timothy O’Sullivan, Gunter Hartel, Graham L. Radford-Smith   +7 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source