Results 91 to 100 of about 25,820 (160)

Cryo-EM structure of the complete E. coli DNA gyrase nucleoprotein complex

Nature Communications, 2019
Bacterial DNA gyrase is the only type II DNA topoisomerase capable of introducing negative supercoils into DNA and is of interest as a drug target. Here the authors present the cryo-EM structure of the complete E. coli DNA gyrase bound to a 180 bp double-
Arnaud Vanden Broeck, Christophe Lotz, Julio Ortiz, Valérie Lamour   +3 more
doaj   +1 more source

DNA gyrase could be a crucial regulatory factor for growth and survival of Mycobacterium leprae

Scientific Reports, 2019
Leprosy, an important infectious disease in humans caused by Mycobacterium leprae (Mle), remains endemic in many countries. Notably, the pathogen cannot be cultured in vitro, except in mouse footpads in vivo.
Hyun Kim, Yasuo Fukutomi, Chie Nakajima, Youn Uck Kim, Shigetarou Mori, Keigo Shibayama, Noboru Nakata, Yasuhiko Suzuki   +7 more
doaj   +1 more source

In-silico design of some tetrazoloquinoline analogs as potent inhibitors of DNA gyrase of Salmonella typhi: QSAR modeling, molecular docking, MD simulation, and ADMET profiling

In Silico Research in Biomedicine
The rising incidences of multi-drug resistance in Salmonella typhi have made the WHO to enlist the bacteria among the highest priority pathogens group that requires urgent attention.
Philip John Ameji, Adamu Uzairu, Gideon Adamu Shallangwa, Sani Uba, Muhammad Tukur Ibrahim   +4 more
doaj   +1 more source

Discovery of Benzopyrone-Based Candidates as Potential Antimicrobial and Photochemotherapeutic Agents through Inhibition of DNA Gyrase Enzyme B: Design, Synthesis, In Vitro and In Silico Evaluation

Pharmaceuticals
Bacterial DNA gyrase is considered one of the validated targets for antibacterial drug discovery. Benzopyrones have been reported as promising derivatives that inhibit bacterial DNA gyrase B through competitive binding into the ATP binding site of the B ...
Akram Abd El-Haleem, Usama Ammar, Domiziana Masci, Sohair El-Ansary, Doaa Abdel Rahman, Fatma Abou-Elazm, Nehad El-Dydamony   +6 more
doaj   +1 more source

Antimicrobial Activity of 2-(Piperazin-1-yl)naphtho[2,3-d]thiazole-4,9-dione against Staphylococcus Strains

Molecules
There is an urgent need to discover and develop novel antibacterial agents. Accordingly, we synthesised 2-(piperazin-1-yl)naphtho[2,3-d]thiazole-4,9-dione (PNT), which exhibits antimicrobial activity.
Tamami Haraguchi, Saki Hayashi, Seira Nakasaka, Yoshiro Hatanaka, Toshihiro Nagao, Shigemitsu Tanaka, Miki Yoshii, Fumiko Hara, Masayori Hagimori, Miyako Yoshida   +9 more
doaj   +1 more source

In-Silico Study of Urea Derivatives as a Potential DNA-Gyrase Inhibitors in Salmonella typhi

Journal of Microbiological Sciences
Salmonella Typhi is the infectious agent that causes typhoid fever. Among this disease's clinical symptoms are elevated body fever, headache, indigestion, body aches, fatigue, and cough. Salmonella Typhi is a pathogenic, rod-shaped, flagellated, and Gram-
Adnan Shahzad, Naseer Ullah, Fazal Dayan, Husna Iqbal, Asad Ullah Khan, Sunbal Khan, Naila, Rafi Ullah, Zahoor Ahamd, Muhammad Talha, Ihsan Ullah, Muhammad Omer, Imad Ud Din, Muhammad Ashfaq, Saqib Ahmad, Izhar Ahmad   +15 more
doaj   +1 more source

Cell Survival Strategies : Role Of Gyrase Modulatory Proteins

, 2008
A steady state level of negative supercoiling is essential for chromosome condensation, initiation of replication and subsequent elongation step. DNA gyrase, found in every eubacteria, serves the essential housekeeping function of maintenance of the ...
Sengupta, Sugopa
core  

All-atoms MD simulations study of newly designed ciprofloxacin derivatives as potential bacterial DHPS and DNA gyrase inhibitors. [PDF]

Front Bioinform
Sahoo CR, Rout M, Paidesetty SK, Dehury B, Bhattacharya D, Pati S.   +5 more
europepmc   +1 more source

Novel Peptide-Triazole Conjugates: Strategic Synthesis, Antimicrobial Properties, and Molecular Docking Study. [PDF]

J Pept Sci
Bhavsar J, Tivari S, Pati SS, Bhanderi P, Makwana B, Khunt R, Kumar N, Chaturvedi VK, Singh R.   +8 more
europepmc   +1 more source

A high-throughput fluorescent DNA cleavage assay for discovering bacterial DNA gyrase poisons. [PDF]

Nucleic Acids Res
Dias M, Annamalai T, Otsuka Y, Leng S, Chapagain T, Ferdous S, Shumate J, Scampavia L, Spicer TP, Leng F.   +9 more
europepmc   +1 more source