Results 81 to 90 of about 25,820 (160)

Transformation of a Thermostable G-Quadruplex Structure into DNA Duplex Driven by Reverse Gyrase

Molecules, 2017
Reverse gyrase is a topoisomerase that can introduce positive supercoils to its substrate DNA. It is demonstrated in our studies that a highly thermal stable G-quadruplex structure in a mini-plasmid DNA was transformed into its duplex conformation after ...
Dawei Li, Qiang Wang, Yun Liu, Kun Liu, Qiang Zhuge, Bei Lv   +5 more
doaj   +1 more source

Alveolar Macrophages: Development, Respiratory Homeostasis, Signal Pathways, Diseases, and Therapeutic Opportunities

MedComm, Volume 7, Issue 10, October 2026.
Alveolar macrophages: development, respiratory homeostasis, signal pathways, diseases, and therapeutic opportunities: During embryonic development, fetal progenitors migrate to the developing lungs via a CX3CR1‐dependent mechanism to establish the TrAM pool.
Sihan Yang, Ruomeng Li, Chuanjiang Yu, Jing Li, Xikun Zhou   +4 more
wiley   +1 more source

Insights into antibacterial design: Computational modeling of eugenol derivatives targeting DNA gyrase

Heliyon
The rise of antibiotic resistance underscores the urgent need for novel antibacterial agents. DNA gyrase, an essential enzyme involved in bacterial DNA replication, is a promising target for antibacterial therapy.
Heba S. Elsewedy, Sultan Alshehri, Adeola T. Kola-Mustapha, Shaymaa M. Genedy, Khuzama M. Siddiq, Bushra Y. Asiri, Rehab A. Alshammari, Heba Mohammed Refat M. Selim, Oluwakorede J. Adedeji, George Oche Ambrose   +9 more
doaj   +1 more source

Metagenomic Characterisation of Antibiotic Resistance in Anaerobic Digesters and Their Implications for Environmental Health

Environmental Microbiology Reports, Volume 18, Issue 5, October 2026.
Anaerobic digester metagenomes revealed diverse resistance‐associated annotations and antibiotic target loci, highlighting their potential role in environmental AMR surveillance. The findings emphasise the need for cautious interpretation of resistome profiles and further host‐resolved analyses to determine the mobility and clinical relevance of ...
Olasunbo Aina Olasupo, Oluwaseyi Paul Olaniyan, Sunday Babatunde Akinde, Ademola Ayodele Adesoye, Fatimah Adenike Ajadi, Omokaro Obire, Elijah Kolawole Oladipo, Waidi Folorunso Sule, Olamilekan Emmanuel Oyinloye, Adedolapo Aishat Salami, Emmanuel Sunday Fajoyegbe, Adejoke Janet Ajani, Olabisi Ojo   +12 more
wiley   +1 more source

Redefining Fluoroquinolone Antibiotics: Design and Synthesis of Degradable Fluoroquinolones to Reduce Environmental Persistence

ChemSusChem, Volume 19, Issue 17, 14 September 2026.
Redesign and development of an efficient, robust synthesis platform for environmentally improved fluoroquinolones. A significant challenge associated with antibiotics, and active pharmaceutical ingredients in general, is their intentional design for high stability, which promotes environmental persistence and contributes to the development of ...
Nathan Raeymackers, Emile De Mol, Martin Yenokyan, Morten Suk, Klaus Kümmerer, Thomas S. A. Heugebaert, Christian V. Stevens   +6 more
wiley   +1 more source

Identification of novel bacterial DNA gyrase inhibitors: An in silico study

Research in Pharmaceutical Sciences, 2016
Owing to essential role in bacterial survival, DNA gyrase has been exploited as a validated drug target. However, rapidly emerging resistance to gyrase-targeted drugs such as widely utilized fluoroquinolones reveals the necessity to develop novel ...
Hamzeh Rahimi, Ali Najafi, Habib Eslami, Babak Negahdari, Mehrdad Moosazadeh Moghaddam   +4 more
doaj  

Schiff Bases of Indoline-2,3-dione: Potential Novel Inhibitors of Mycobacterium Tuberculosis (Mtb) DNA Gyrase

Molecules, 2011
In the present study a series of Schiff bases of indoline-2,3-dione were synthesized and investigated for their Mtb gyrase inhibitory activity. Promising inhibitory activity was demonstrated with some of these derivatives, which exhibited IC50 values ...
Jane Thanassi, Michael J. Pucci, Tarek Aboul-Fadl, Hatem A. Abdel-Aziz, Tilal Elsaman, Mohammed K. Abdel-Hamid   +5 more
doaj   +1 more source

A Mycobacterium smegmatis gyrase B specific monoclonal antibody reveals association of gyrase A and B subunits in the cell [PDF]

, 2001
DNA gyrase is a unique topoisomerase, which plays important roles in macromolecular events like DNA replication, transcription and genetic recombination.
Visweswariah, S. S., Manjunatha, U. H., Somesh, B. P., Nagaraja, V.   +3 more
core   +1 more source

Molecular mechanism of a triazole-containing inhibitor of Mycobacterium tuberculosis DNA gyrase

iScience
Summary: Antimicrobial resistance remains a persistent and pressing public health concern. Here, we describe the synthesis of original triazole-containing inhibitors targeting the DNA gyrase, a well-validated drug target for developing new antibiotics ...
Antoine Gedeon, Emilie Yab, Aurelia Dinut, Elodie Sadowski, Estelle Capton, Aurore Dreneau, Julienne Petit, Bruna Gioia, Catherine Piveteau, Kamel Djaout, Estelle Lecat, Anne Marie Wehenkel, Francesca Gubellini, Ariel Mechaly, Pedro M. Alzari, Benoît Deprez, Alain Baulard, Alexandra Aubry, Nicolas Willand, Stéphanie Petrella   +19 more
doaj   +1 more source

Docking studies on novel analogs of quinolones against DNA gyrase of Escherichia coli [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2018
Context: Bacterial resistance to antibiotics is the inevitable consequence of the use of antimicrobial agents. Thus, quinolones are an important class of antibacterials; these agents generally consist of a 1-subtituted-1,4-dihydro-4-oxopyridine-3 ...
Cristian Davila, Lorena Llach, Guillermo Salgado-Moran, Rodrigo Ramirez-Tagle   +3 more
doaj