Results 61 to 70 of about 25,820 (160)

Molecular Characterization of the Gene Encoding the DNA Gyrase A Subunit of Streptococcus pneumoniae

, 1998
The gene encoding the DNA gyrase A subunit of Streptococcus pneumoniae was cloned and sequenced. The gyrA gene codes for a protein of 822 amino acids homologous to the gyrase A subunit of eubacteria.
Balas, Delia, Campa, Adela G. de la, Fernández Moreira, Esteban   +2 more
core   +1 more source

Mechanism of Action of Mycobacterium tuberculosis Gyrase Inhibitors: A Novel Class of Gyrase Poisons [PDF]

, 2018
Tuberculosis is one of the leading causes of morbidity worldwide, and the incidences of drug resistance and intolerance are prevalent. Thus, there is a desperate need for the development of new antitubercular drugs.
Gibson, Elizabeth G., Blower, T.R., Tim R. Blower, Gibson, E.G., Elizabeth G. Gibson, Monica Cacho, Berger, J.M., Cacho, Monica, Bax, B., Berger, James M., Cacho, M., Osheroff, Neil, Osheroff, N., Bax, Ben, Ben Bax, Neil Osheroff, Blower, Tim R., James M. Berger   +17 more
core   +1 more source

Multifunctional Curcumin-Inspired 3,5-Diarylidene-4-Piperidones: Design, Synthesis, Biological Evaluation and Computational Mechanistic Studies

Pharmaceuticals
Background/Objectives: Antimicrobial resistance and bacterial persistence underscore the need to develop new chemotypes with multifunctional antibacterial mechanisms.
Angel K. Nkosi, Adel S. Girgis, Ahmed Samir, Mohamed A. Morsy, Amira M. Shaban, Walid Fayad, Ahmed A. F. Soliman, Christine T. Williams, Shogo Mori, Leena Khanna, Guido F. Verbeck, Siva S. Panda   +11 more
doaj   +1 more source

Structural insights into the quinolone resistance mechanism of Mycobacterium tuberculosis DNA gyrase. [PDF]

PLoS ONE, 2010
Mycobacterium tuberculosis DNA gyrase, an indispensable nanomachine involved in the regulation of DNA topology, is the only type II topoisomerase present in this organism and is hence the sole target for quinolone action, a crucial drug active against ...
Jérémie Piton, Stéphanie Petrella, Marc Delarue, Gwénaëlle André-Leroux, Vincent Jarlier, Alexandra Aubry, Claudine Mayer   +6 more
doaj   +1 more source

Strain‐specific monitoring of Bacillus amyloliquefaciens AH2 in strawberry fields using a specific molecular marker

Pest Management Science, EarlyView.
A novel strain‐specific TaqMan quantitative polymerase chain reaction assay targeting the hsdM gene was developed to monitor Bacillus amyloliquefaciens AH2 in strawberries, providing a foundational tool to optimize biocontrol management. Abstract BACKGROUND The biocontrol agent Bacillus amyloliquefaciens AH2 is effective against Botrytis cinerea in ...
M Mercedes Maldonado‐González, Julio Rodríguez‐Romero, Jonatan C Campillo‐Brocal, Pedro R Molina‐Guevara, María Sánchez‐García, Laura Martínez‐Pozuelo, Antonio Bernal‐Soro, María A Ayllón   +7 more
wiley   +1 more source

Structural analysis of Helicobacter pylori glutamate racemase in a monoclinic crystal form

Acta Crystallographica Section F, EarlyView.
The crystal structure of H. pylori MurI is reported at 1.43 Å resolution.Glutamate racemase (MurI) catalyzes the stereochemical interconversion of l‐glutamate and d‐glutamate, a key element of bacterial peptidoglycan biosynthesis. In this study, we present the crystal structure of Helicobacter pylori glutamate racemase at 1.43 Å resolution and with ...
Maria Spiliopoulou, Eike C. Schulz
wiley   +1 more source

Phenotypic Florfenicol Resistance in floR‐Harbouring Flavobacterium psychrophilum Isolates (CC‐ST90): A Case Study From Danish Freshwater Rainbow Trout Aquaculture

Journal of Fish Diseases, EarlyView.
ABSTRACT Monitoring antimicrobial resistance (AMR) in fish pathogens is essential for supporting sustainable aquaculture. In this study, susceptibility testing and genome sequencing were used to characterize the AMR profile of seven Flavobacterium psychrophilum originating from Danish rainbow trout farms (2019–2022).
Valentina L. Donati, Lone Madsen
wiley   +1 more source

Friend or Foe: Protein Inhibitors of DNA Gyrase

Biology
DNA gyrase is essential for the successful replication of circular chromosomes, such as those found in most bacterial species, by relieving topological stressors associated with unwinding the double-stranded genetic material.
Shengfeng Ruan, Chih-Han Tu, Christina R. Bourne   +2 more
doaj   +1 more source

Epidemiology of Neisseria gonorrhoeae Gyrase A Genotype, Los Angeles, California, USA

Emerging Infectious Diseases, 2017
We investigated the epidemiology of the mutant gyrase A gene, a reliable predictor of ciprofloxacin resistance, in Neisseria gonorrhoeae infections at UCLA Health in Los Angeles, California, USA, during November 1, 2015–August 31, 2016.
Ashima A. Bhatti, Lao-Tzu Allan-Blitz, Mariana Castrejon, Romney Humphries, Peera Hemarajata, Jeffrey D. Klausner   +5 more
doaj   +1 more source

Isolation and Identification of Erysipelothrix sp. in Hybrid Grouper (Epinephelus fuscoguttatus × E. lanceolatus) in Taiwan

Journal of Fish Diseases, EarlyView.
ABSTRACT In February 2025, a mortality event of unknown aetiology occurred at a hybrid grouper (Epinephelus fuscoguttatus × Epinephelus lanceolatus) aquaculture farm in southern Taiwan, with sporadic daily deaths persisting for a month. Four moribund groupers were collected over three sampling intervals for diagnostic investigation.
Shang‐Ting Wu, Yu‐Siang Lin, Chia‐Yu Hsieh   +2 more
wiley   +1 more source