Results 11 to 20 of about 38,819 (204)

Dynamic regulation of H3K27 trimethylation during Arabidopsis differentiation. [PDF]

PLoS Genetics, 2011
During growth of multicellular organisms, identities of stem cells and differentiated cells need to be maintained. Cell fate is epigenetically controlled by the conserved Polycomb-group (Pc-G) proteins that repress their target genes by catalyzing ...
Marcel Lafos, Phillip Kroll, Mareike L Hohenstatt, Frazer L Thorpe, Oliver Clarenz, Daniel Schubert   +5 more
doaj   +1 more source

Ras-induced changes in H3K27me3 occur after those in transcriptional activity. [PDF]

PLoS Genetics, 2013
Oncogenic signaling pathways regulate gene expression in part through epigenetic modification of chromatin including DNA methylation and histone modification.
Masaki Hosogane, Ryo Funayama, Yuichiro Nishida, Takeshi Nagashima, Keiko Nakayama   +4 more
doaj   +1 more source

DNMT1 modulates interneuron morphology by regulating Pak6 expression through crosstalk with histone modifications

Epigenetics, 2018
Epigenetic mechanisms of gene regulation, including DNA methylation and histone modifications, call increasing attention in the context of development and human health.
Judit Symmank, Cathrin Bayer, Christiane Schmidt, Anne Hahn, Daniel Pensold, Geraldine Zimmer-Bensch   +5 more
doaj   +1 more source

Increased brain-derived neurotrophic factor exon IV histone 3 lysine 9 dimethylation in patients with schizophrenia

Taiwanese Journal of Psychiatry, 2019
Background: Studies have mentioned that mixed-lineage leukemia 1 (MLL1) and histone 3 lysine 4 trimethylation (H3K4me3) of brain-derived neurotrophic factor (BDNF) exon IV from the postmortem brain tissue of patients with schizophrenia are related to the
Men-Ting Hsieh, Chin-Chuen Lin, Tiao-Lai Huang   +2 more
doaj   +1 more source

Genome-wide profiling of histone H3 lysine 27 trimethylation and its modification in response to chilling stress in grapevine leaves

Horticultural Plant Journal, 2023
Histone H3 lysine 27 trimethylation (H3K27me3) is a histone modification associated with transcriptional repression. However, insights into the genome-wide pattern of H3K27me3 in grapevines are limited.
Zhenfei Zhu, Qingyun Li, Duncan Kiragu Gichuki, Yujun Hou, Yuanshuang Liu, Huimin Zhou, Chen Xu, Linchuan Fang, Linzhong Gong, Beibei Zheng, Wei Duan, Peige Fan, Qingfeng Wang, Haiping Xin   +13 more
doaj   +1 more source

Impact of H3K27 trimethylation loss in meningiomas: a meta-analysis

Acta Neuropathologica Communications, 2023
Trimethylation of lysine 27 on histone 3 (H3K27me3) loss has been implicated in worse prognoses for patients with meningiomas. However, there have been challenges in measuring H3K27me3 loss, quantifying its impact, and interpreting its clinical utility ...
Gregory Cello, Ruchit V. Patel, James Tanner McMahon, Sandro Santagata, Wenya Linda Bi   +4 more
doaj   +1 more source

The chromodomain of LIKE HETEROCHROMATIN PROTEIN 1 is essential for H3K27me3 binding and function during Arabidopsis development. [PDF]

PLoS ONE, 2009
Polycomb group (PcG) proteins are essential to maintain gene expression patterns during development. Transcriptional repression by PcG proteins involves trimethylation of H3K27 (H3K27me3) by Polycomb Repressive Complex 2 (PRC2) in animals and plants ...
Vivien Exner, Ernst Aichinger, Huan Shu, Thomas Wildhaber, Pietro Alfarano, Amedeo Caflisch, Wilhelm Gruissem, Claudia Köhler, Lars Hennig   +8 more
doaj   +1 more source

Ezh2 Inhibits Replicative Senescence of Atrial Fibroblasts Through Promotion of H3K27me3 in the Promoter Regions of CDKN2a and Timp4 Genes

Journal of Inflammation Research, 2022
Yingze Li,* Guojian Fang,* Wei Cao,* Jiali Yuan,* Shuai Song, Hong Peng, Yuepeng Wang, Qunshan Wang Department of Cardiology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 200092, People’s ...
Li Y, Fang G, Cao W, Yuan J, Song S, Peng H, Wang Y, Wang Q   +7 more
doaj  

Active H3K27me3 demethylation by KDM6B is required for normal development of bovine preimplantation embryos

Epigenetics, 2017
The substantial epigenetic remodeling that occurs during early stages of mammalian embryonic development likely contributes to reprogramming the parental genomes from a differentiated to a totipotent state and activation of the embryonic genome ...
Nhi Chung, Yanina S. Bogliotti, Wei Ding, Marcela Vilarino, Kazuki Takahashi, James L. Chitwood, Richard M. Schultz, Pablo J. Ross   +7 more
doaj   +1 more source

Lack of Transcription Triggers H3K27me3 Accumulation in the Gene Body

Cell Reports, 2016
Trimethylated H3K27 (H3K27me3) is associated with transcriptional repression, and its abundance in chromatin is frequently altered in cancer. However, it has remained unclear how genomic regions modified by H3K27me3 are specified and formed.
Masaki Hosogane, Ryo Funayama, Matsuyuki Shirota, Keiko Nakayama   +3 more
doaj   +1 more source