Results 91 to 100 of about 41,916 (253)

Deep mutational scanning of hemagglutinin helps predict evolutionary fates of human H3N2 influenza variants

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance A key goal in the study of influenza virus evolution is to forecast which viral strains will persist and which ones will die out. Here we experimentally measure the effects of all amino acid mutations to the hemagglutinin protein from a ...
Juhye M. Lee, J. Huddleston, Michael B. Doud, K. Hooper, N. Wu, T. Bedford, J. Bloom   +6 more
semanticscholar   +1 more source

Influenza Hemagglutinin Nanoparticle Vaccine Elicits Broadly Neutralizing Antibodies against Structurally Distinct Domains of H3N2 HA

Vaccines, 2020
Influenza vaccine effectiveness varies annually due to the fast evolving seasonal influenza A(H3N2) strain and egg-derived mutations—both of which can cause a mismatch between the vaccine and circulating strains.
Alyse D. Portnoff, N. Patel, M. Massare, Haixia Zhou, Jing-hui Tian, Bin Zhou, V. Shinde, G. Glenn, Gale Smith   +8 more
semanticscholar   +1 more source

The X Factor in Immunity: Sex Differences Shaped by the X Chromosome

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT There are sex differences with immune responses where females exhibit stronger immune responses compared to males. Both sex hormones and sex chromosome differences between males and females contribute to the observed sex differences with innate and adaptive immune cell composition and function.
Katherine B. Radovanovic, Megan Wynalda, Montserrat C. Anguera   +2 more
wiley   +1 more source

Human-to-Human Transmission of Influenza A(H3N2) Virus with Reduced Susceptibility to Baloxavir, Japan, February 2019

Emerging Infectious Diseases, 2019
In 2019, influenza A(H3N2) viruses carrying an I38T substitution in the polymerase acidic gene, which confers reduced susceptibility to baloxavir, were detected in Japan in an infant without baloxavir exposure and a baloxavir-treated sibling.
E. Takashita, Masataka Ichikawa, H. Morita, Rie Ogawa, Seiichiro Fujisaki, Masayuki Shirakura, H. Miura, Kazuya Nakamura, N. Kishida, Tomoko Kuwahara, Hiromi Sugawara, Aya Sato, Miki Akimoto, K. Mitamura, Takashi Abe, M. Yamazaki, Shinji Watanabe, H. Hasegawa, T. Odagiri   +18 more
semanticscholar   +1 more source

A Systematic Review on Functional Bioactive Compound Atractylone: Natural Source, Pharmacological Properties and Mechanisms Insights

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Atractylone exhibits diverse pharmacological effects, including anticancer and neuroprotection. A systematic review was conducted following PRISMA guidelines to analyze Atractylone. This study explores Atractylone's sources, biosynthesis, and therapeutic potential.
Hamza Elhrech, Oumayma Aguerd, Meriem El Fessikh, Zouhair Essahli, Taoufiq Benali, Waleed Al Abdulmonem, Learn‐Han Lee, Imane Chamkhi, Abdelhakim Bouyahya   +8 more
wiley   +1 more source

Intraseasonal Dynamics and Dominant Sequences in H3N2 Influenza

PLoS ONE, 2010
Long-term influenza evolution has been well studied, but the patterns of sequence diversity within seasons are less clear. H3N2 influenza genomes sampled from New York State over ten years indicated intraseasonal changes in evolutionary dynamics. Using the mean Hamming distance of a set of amino acid or nucleotide sequences as an indicator of its ...
Nicole Creanza, Jason S Schwarz, Joel E Cohen   +2 more
openaire   +4 more sources

H3N2 canine influenza virus-like particle vaccine with great protection in beagle dogs

Microbiology Spectrum
In 2016, a distinct branch of H3N2 canine influenza virus (CIV) emerged, which has mutations related to mammalian adaptation and has replaced previously prevalent strains. This branch poses a risk of zoonotic infection.
Fei-fei Ge, Li-pin Shen, De-quan Yang, Xian-cao Yang, Xin Li, Hai-xiao Shen, Jian Wang, Shixin Huang   +7 more
doaj   +1 more source

Detection of influenza A(H3N2) viruses exhibiting reduced susceptibility to the novel cap-dependent endonuclease inhibitor baloxavir in Japan, December 2018

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2019
The novel cap-dependent endonuclease inhibitor baloxavir marboxil was approved for the treatment of influenza virus infection in Japan in February 2018.
E. Takashita, C. Kawakami, H. Morita, Rie Ogawa, Seiichiro Fujisaki, Masayuki Shirakura, H. Miura, Kazuya Nakamura, N. Kishida, Tomoko Kuwahara, K. Mitamura, Takashi Abe, Masataka Ichikawa, M. Yamazaki, Shinji Watanabe, T. Odagiri   +15 more
semanticscholar   +1 more source

Antigenic assessment of the H3N2 component of the 2019-2020 Northern Hemisphere influenza vaccine

Nature Communications, 2020
The 2019–2020 Northern Hemisphere influenza vaccine includes antigens from 3c3.A H3N2 viruses; however, over half of circulating H3N2 viruses belong to subclade 3c2.A1b.
S. Gouma, M. Weirick, S. Hensley
semanticscholar   +1 more source

Hydroxypropyl Cellulose Enhances Immune Responses to the Current Seasonal Influenza Vaccine in Mice

Microbiology and Immunology, Volume 70, Issue 2, Page 68-79, February 2026.
ABSTRACT Influenza A and B viruses cause annual epidemics and continue to pose global public health concerns. The most effective approach to preventing or mitigating the severity of influenza is vaccination. Inactivated split influenza HA vaccines are commonly used worldwide due to their strong safety profile and broad range of target groups; however ...
Nantaporn Kaewaroon, Sara Yoshimoto, Luthfi Muawan, Shintaro Shichinohe, Tokiko Watanabe   +4 more
wiley   +1 more source