Results 111 to 120 of about 50,945 (202)

Vaccine Epidemiology and Decision-Making: A Bryant Student Focus [PDF]

, 2018
The Centers for Disease Control and Prevention estimate that influenza has resulted in between 9.2 and 35.6 million illnesses and between 12,000 and 56,000 deaths annually since 2010 (1).
Coburn, Hannah
core   +1 more source

Altered Cytokine‐Induced STAT3 and STAT5 Activation of Peripheral T Follicular Helper Cells Contributes to Vaccine‐Non‐Responsiveness in Aging and HIV

Aging Cell, Volume 25, Issue 3, March 2026.
Chronic immune activation and inflammation associated with aging and HIV skew Tfh signaling toward enhanced IL‐2–STAT5 activation, reinforcing IL‐2R expression through a positive feedback loop and suppressing Tfh helper differentiation programs, thereby contributing to impaired vaccine responsiveness.
Sheldon Davis, Jonah Kupritz, Prabhsimran Singh, Savita Pahwa, Suresh Pallikkuth   +4 more
wiley   +1 more source

The X Factor in Immunity: Sex Differences Shaped by the X Chromosome

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT There are sex differences with immune responses where females exhibit stronger immune responses compared to males. Both sex hormones and sex chromosome differences between males and females contribute to the observed sex differences with innate and adaptive immune cell composition and function.
Katherine B. Radovanovic, Megan Wynalda, Montserrat C. Anguera   +2 more
wiley   +1 more source

Early Prediction of Antigenic Transitions for Influenza A H3N2

PLOS Computational Biology, 2019
AbstractInfluenza A/H3N2 is a rapidly evolving virus which experiences major antigenic transitions every two to eight years. Anticipating the timing and outcome of transitions is critical to developing effective seasonal influenza vaccines. Using simulations from a published phylodynamic model of influenza transmission, we identified indicators of ...
Lauren A. Castro, Trevor Bedford, Lauren Ancel Meyers   +2 more
openaire   +4 more sources

Dynamic adaptation mutations and pathogenic characterization of a mouse-adapted seasonal human H3N2 influenza virus

Virology Journal
Background H3N2 influenza A viruses [A(H3N2)] circulate as seasonal influenza in humans worldwide, resulting in a huge disease burden. Adaptation study of A(H3N2) in mice could provide a basis for preclinical evaluation of antivirals and vaccines ...
Cheng Zhang, Yan Li, Ning Zhang, Ju Sun, Deyu Tian, Xuefeng Duan, Jing Yang, Yuhai Bi   +7 more
doaj   +1 more source

Influenza Vaccination of young children or Antibody Immune Response and Protection after Inactivated Influenza Vaccine in Children – A Literature Review [PDF]

, 2020
Influenza virus infection is a major cause of morbidity and mortality in at risk populations. Children, especially under the age of two, are at an increased risk of complications associated with influenza virus infection.
wall, danielle
core   +1 more source

Strain Agnostic Influenza Virus Propagation in a Serum‐Free, Suspension‐Adapted MDCK Cell Line

Influenza and Other Respiratory Viruses, Volume 20, Issue 3, March 2026.
ABSTRACT Background The continuing circulation and evolution of seasonal influenza viruses remains a public health and socioeconomic threat on a global scale. Viral surveillance and vaccination of the public have been relied upon to confer and boost immunity in the population. Traditionally, influenza strains are propagated in embryonated chicken eggs,
Jessica B. Huskey, Michelle L. Rock, Pooja V. Chaudhary, Emily C. Hill, Madeline E. Hoover, Nicole M. Rideout, Kamerin D. Dean, Thomas Scott Alderman, Phong Ho, M. Anthony Moody, Gregory D. Sempowski, Thomas H. Oguin III   +11 more
wiley   +1 more source

Synergistic effects of PA (S184N) and PB2 (E627K) mutations on the increased pathogenicity of H3N2 canine influenza virus infections in mice and dogs

Journal of Virology
As companion animals, dogs are susceptible to various subtypes of influenza A virus (IAV), with the H3N2 and H3N8 subtypes of canine influenza virus (CIV) stably circulating among canines.
Xiangyu Xiao, Xinrui Wang, Fengpei Xu, Yanting Liang, Yi Luo, Shoujun Li, Pei Zhou   +6 more
doaj   +1 more source

Risk and protective factors for meningococcal disease in adolescents: matched cohort study [PDF]

, 2006
Objective: To examine biological and social risk factors for meningococcal disease in adolescents. Design: Prospective, population based, matched cohort study with controls matched for age and sex in 1:1 matching.
Booth, C., Booy, R., Coen, P.G., Kaczmarski, E., Klein, N., Peckham, C., Stuart, J.M., Tully, J., Viner, R.M., Zambon, M.   +9 more
core  

Influenza Vaccine Effectiveness Against Influenza A(H1N1)pdm09‐Associated Hospitalizations With SARI in Beijing, China, in the 2024–2025 Season

Influenza and Other Respiratory Viruses, Volume 20, Issue 3, March 2026.
ABSTRACT Background In the 2024–2025 season, influenza activity returned to pre‐COVID‐19 pandemic levels, with A(H1N1)pdm09 as the predominant subtype. Reassessment vaccine effectiveness (VE) in hospitalized patients is critical to inform potential adjustments to vaccination policy.
Chunna Ma, Ying Sun, Jiaxin Ma, Yingying Wang, Xiaodi Hu, Ying Shen, Li Zhang, Jiaojiao Zhang, Lu Zhang, Wei Duan, Jia Li, Quanyi Wang, Daitao Zhang, Peng Yang   +13 more
wiley   +1 more source