Results 21 to 30 of about 52,761 (267)

Bivalent H1 and H3 COBRA Recombinant Hemagglutinin Vaccines Elicit Seroprotective Antibodies against H1N1 and H3N2 Influenza Viruses from 2009 to 2019

Journal of Virology, 2022
Standard-of-care influenza virus vaccines are composed of a mixture of antigens from different influenza viral subtypes. For the first time, lead COBRA H1 and H3 HA antigens, formulated as a bivalent vaccine, have been investigated in animals with ...
James D. Allen, T. Ross
semanticscholar   +1 more source

Influenza Vaccine Effectiveness Against Influenza A(H3N2)-Related Illness in the United States During the 2021-2022 Influenza Season

medRxiv, 2022
Background. In the United States, influenza activity during the 2021-2022 season was modest and sufficient enough to estimate influenza vaccine effectiveness for the first time since the beginning of the COVID-19 pandemic.
A. Price, B. Flannery, K. Talbot, Carlos G. Grijalva, K. Wernli, H. Phillips, A. Monto, E. Martin, E. Belongia, H. McLean, M. Gaglani, M. Mutnal, K. M. Geffel, M. Nowalk, S. Tartof, A. Florea, C. McLean, S. Kim, M. Patel, J. Chung   +19 more
semanticscholar   +1 more source

Antigenic and virological properties of an H3N2 variant that continues to dominate the 2021–22 Northern Hemisphere influenza season

Cell Reports, 2022
Influenza viruses circulated at very low levels during the beginning of the COVID-19 pandemic, and population immunity against these viruses is low. An H3N2 strain (3C.2a1b.2a2) with a hemagglutinin (HA) that has several substitutions relative to the ...
M. Bolton, Jordan T. Ort, R. McBride, N. J. Swanson, Joelle M. Wilson, M. Awofolaju, Colleen Furey, A. Greenplate, E. Drapeau, A. Pekosz, J. Paulson, Scott E. Hensley   +11 more
semanticscholar   +1 more source

veg/IAV-H3N2-analysis: Release to support paper publication

, 2021
Comparative analysis of H3N2 human/avian/mammalian ...
Sergei Pond
core   +1 more source

Explaining the geographical origins of seasonal influenza A (H3N2) [PDF]

Proceedings of the Royal Society B: Biological Sciences, 2016
Most antigenically novel and evolutionarily successful strains of seasonal influenza A (H3N2) originate in East, South and Southeast Asia. To understand this pattern, we simulated the ecological and evolutionary dynamics of influenza in a host metapopulation representing the temperate north, tropics and temperate south.
Frank Wen, Trevor Bedford, Sarah Cobey
openaire   +3 more sources

Study of the host specificity of PB1-F2-associated virulence

Virulence, 2021
Influenza A viruses cause important diseases in both human and animal. The PB1-F2 protein is a virulence factor expressed by some influenza viruses.
Joëlle Mettier, Daniel Marc, Laura Sedano, Bruno Da Costa, Christophe Chevalier, Ronan Le Goffic   +5 more
doaj   +1 more source

Next generation methodology for updating HA vaccines against emerging human seasonal influenza A(H3N2) viruses

Scientific Reports, 2021
While vaccines remain the best tool for preventing influenza virus infections, they have demonstrated low to moderate effectiveness in recent years. Seasonal influenza vaccines typically consist of wild-type influenza A and B viruses that are limited in ...
James D. Allen, T. Ross
semanticscholar   +1 more source

National Influenza Mid-Season Report, 2019–2020

Canada Communicable Disease Report, 2020
Canada’s national influenza season started in week 47 between November 17 to 23, 2019. Of the 3,762 laboratory-confirmed influenza detections reported from August 25 to December 14, 2019, 61% were influenza A, and of those subtyped, 68% were A(H3N2 ...
Claire Sevenhuysen, Liza Lee, Andrea Nwosu, Tiffany Smith, Lindsay Whitmore, Nathalie Bastien, Mireille Desroches, Christina Bancej   +7 more
doaj   +1 more source

Opposing Effects of Prior Infection versus Prior Vaccination on Vaccine Immunogenicity against Influenza A(H3N2) Viruses

Viruses, 2022
Prior vaccination can alternately enhance or attenuate influenza vaccine immunogenicity and effectiveness. Analogously, we found that vaccine immunogenicity was enhanced by prior A(H3N2) virus infection among participants of the Ha Nam Cohort, Viet Nam ...
A. Fox, L. Carolan, V. Leung, P. Hoàng, A. Khvorov, Maria Auladell, Yeu-Yang Tseng, T. M. Pham, I. Barr, K. Subbarao, L. Mai, H. V. van Doorn, Sheena G. Sullivan   +12 more
semanticscholar   +1 more source

Antigenicity prediction and vaccine recommendation of human influenza virus A (H3N2) using convolutional neural networks

Human Vaccines & Immunotherapeutics, 2020
The rapid evolution of influenza A viruses poses a great challenge to vaccine development. Analytical and machine learning models have been applied to facilitate the process of antigenicity determination.
Eva K. Lee, Haozheng Tian, Helder I. Nakaya   +2 more
doaj   +1 more source