Results 11 to 20 of about 67,829 (223)

Evolution of H5N1 Cross-Species Transmission: Adaptive Mutations Driving Avian-to-Human Infection. [PDF]

Adv Genet (Hoboken)
This review synthesizes current knowledge on the molecular mechanisms underpinning H5N1's host adaptation, focusing on key mutations in viral proteins. Critical mutations are discussed in detail, highlighting their roles in altering receptor specificity, promoting antiviral resistance, and expanding viral tropism. The review underscores the urgent need
Man W, Du L, Liu Y, Pang Z, Zhu H, Hong B, Xu Z, Fan H.   +7 more
europepmc   +2 more sources

Evidence of High Pathogenic Avian Influenza H5N1 Clade 2.3.4.4b Among Poultry in Ghana From 2021 to 2022. [PDF]

Vet Med Sci
Ghana experienced outbreaks of highly pathogenic avian influenza A H5N1 among poultry from 2021 to 2022. Analysing poultry, pigs, and environmental samples showed H5N1 prevalence of 2.36% (63/2640) among poultry only. The clade 2.3.4.4b virus showed mammalian adaptive motifs in haemagglutinin, emphasising the need for ongoing genomic surveillance among
Nyarko SO, Asante IA, Sarpong GM, Boatemaa L, Kwasah L, Awuku-Larbi Y, Magnusen V, Wutsika J, Ago S, Amenuvor EAA, Adusei-Poku M, Ntim NAA, Wordui J, Sekyi-Yorke AN, Takyi C, Nyarko JA, Quarcoo JA, Doku I, Tackie RA, Odoom T, Danso F, Nyarko EO, Asiedu W, Mingle DL, Attram N, Cameron-Paintsil S, Terrel S, Miranda H, Ampofo WK.   +28 more
europepmc   +2 more sources

Detection of Two High Pathogenicity Avian Influenza Virus (HPAIV) Subtypes, H5N1 and H5N5, in a Mass Mortality Event in Wild Seabirds and Co-Location With Dead Seals. [PDF]

Transbound Emerg Dis
H5Nx Clade 2.3.4.4b high pathogenicity avian influenza viruses (HPAIVs) have been detected repeatedly in Great Britain (GB) since autumn 2020, with H5N1 dominating detections but with low level detection of H5N5 during 2025. Globally, these viruses have caused mass mortalities in captive and wild avian and mammalian populations, including terrestrial ...
Falchieri M, Bentley E, Coombes HA, Mollett BC, Terrey J, Holland S, Stubbings E, Mcginn N, Cooper J, Ahmad S, Lewis J, Clifton B, Collinson N, Aegerter J, Venkatesh D, Russell DJF, James J, Reid SM, Banyard AC.   +18 more
europepmc   +2 more sources

H5N1 Clade 2.2 Polymorphism Tracing Identifies Influenza Recombination and Potential Vaccine Targets [PDF]

, 2007
Highly pathogenic Influenza A H5N1 was first identified in Guangdong Province in 1996, followed by human cases in Hong Kong in 1997 1. The number of confirmed human cases now exceeds 300 and the associated Case Fatality Rate exceeds 60% 2.
A Abdelghani, A Nayei, A-SA Arafa, Bruce Boynton, E Ayoub, Elassai Labib, Hala Essmat, Henry Niman, Henry Niman, Jeffery Tjaden, Kenneth Earhart, Magdi Saad, Marshall Monteville, Mona Aly, Moustafa Mansour, Nasr ElSayed   +15 more
core   +3 more sources

RESULTS OF EXPERIMENTAL INFECTION OF TURKEYS WITH A/DUCK/ALTAI/469/14 H5N1 STRAIN OF AVIAN INFLUENZA VIRUS

Ветеринария сегодня, 2018
The data on experimental infection of 6-week-old Big-6 cross turkeys with an epidemic A/duck/Altai/469/14 H5N1 clade 2.3.2.1c strain of avian influenza virus are presented.
V. Yu. Sosipatorova, D. A. Altunin, I. A. Chvala, N. S. Mudrak, D. B. Andreychuk   +4 more
doaj   +1 more source

One-way trip: Influenza virus' adaptation to gallinaceous poultry may limit its pandemic potential [PDF]

, 2014
We hypothesise that some influenza virus adaptations to poultry may explain why the barrier for human-to-human transmission is not easily overcome once the virus has crossed from wild birds to chickens.
Alexander, Baigent, Banks, Banks, Belser, Blumenkrantz, Bosch, Brass, Bullough, Butt, Castrucci, Cauldwell, Chan, Chen, Chen, Cheng, Chutinimitkul, Cohen, Connor, Costa, Cotter, Cowling, Cox, De Jong, Dorigatti, DuBois, Elderfield, England, Everitt, Gabbard, Galloway, Gambaryan, Gambaryan, Gao, Garten, Handel, Harvey, Hatta, Hay, Herfst, Hoffmann, Imai, Jia, Karron, Keleta, Killingley, Koerner, Koopmans, Krenn, Kuchipudi, Li, Li, Lin, Lin, Linster, Luke, Maines, Matrosovich, Matrosovich, Matrosovich, Matrosovich, Matsuoka, Munier, Neumann, O'Donnell, Pappas, Peiris, Perdue, Reed, Roberts, Robinson, Roche, Rogers, Rott, Russell, Russell, Schrauwen, Shelton, Shi, Skehel, Smeenk, Sorrell, Sorrell, Steinhauer, Stevens, Suguitan, Sun, Tellier, Tharakaraman, Thoennes, Tumpey, Vines, Wan, Wang, Washington, Webster, Wei, Xiong, Yen, Zhang, Zhou, Zhou   +101 more
core   +2 more sources

International Laboratory Comparison of Influenza Microneutralization Assays for A(H1N1) pdm09, A(H3N2), and A(H5N1) Influenza Viruses by CONSISE [PDF]

, 2015
The microneutralization assay is commonly used to detect antibodies to influenza virus, and multiple protocols are used worldwide. These protocols differ in the incubation time of the assay as well as in the order of specific steps, and even within ...
Engelhardt, OG, Heath, A, Hoschler, K, Hungnes, O, Katz, JM, Laurie, KL, Peiris, M, Van Kerkhove, MD, Wood, J, Zhang, W   +9 more
core   +1 more source

H5N1 moratorium [PDF]

Bioengineered, 2012
The recent moratorium on research using engineered H5N1 influenza viruses is a move which cannot achieve its aims as it ignores the prevalence of molecular biology.
openaire   +2 more sources

Prediction of specific virus outbreaks made from the increased concentration of a new class of virus genomic peptides, replikins. [PDF]

, 2011
Advance warning of pathogen outbreaks has not been possible heretofore. A new class of genomic peptides associated with rapid replication was discovered and named replikins. Software was designed to analyze replikins quantitatively.
Elenore S. Bogoch, Samuel Bogoch
core   +2 more sources

Marked Rise in Replikin Counts in H5N1 Influenza Virus Localized to Lethality Gene p B1. [PDF]

, 2011
: Virus outbreaks have been found to be related to the concentration of a new class of genomic peptides, Replikins^1^. The eight genes of H5N1 influenza virus were analyzed for the distribution of Replikin Counts (number Replikins /100 amino acids) in 2 ...
Elenore S. Bogoch, Samuel Bogoch
core   +2 more sources