Differentiation of mammalian vestibular hair cells from conditionally immortal, postnatal supporting cells [PDF]
, 1999 We provide evidence from a newly established, conditionally immortal cell line (UB/UE-1) that vestibular supporting cells from the mammalian inner ear can differentiate postnatally into more than one variant of hair cell.
Holley, M.C. +4 more
core +1 more source
Molecular characterization and prospective isolation of human fetal cochlear hair cell progenitors
Nature Communications, 2018 Sensory hair cells located in the organ of Corti are essential for cochlear mechanosensation. Their loss is irreversible in humans resulting in permanent hearing loss.
M. Roccio +5 more
semanticscholar +1 more source
Olfactory receptor OR2AT4 regulates human hair growth
Nature Communications, 2018 Increasing evidence suggest that olfactory receptors can carry additional functions besides olfaction. Here, Chéret et al. show that stimulation of the olfactory receptor ORT2A4 by the odorant Sandalore® stimulates growth of human scalp hair follicles ex
Jérémy Chéret +7 more
doaj +1 more source
Hybrid in vitro diffusion cell for simultaneous evaluation of hair and skin decontamination: temporal distribution of chemical contaminants [PDF]
, 2018 Most casualty or personnel decontamination studies have focused on removing contaminants from the skin. However, scalp hair and underlying skin are the most likely areas of contamination following airborne exposure to chemicals. The aim of this study was
A Roul +21 more
core +2 more sources
Cellular glutathione content in the organ of Corti and its role during ototoxicity. [PDF]
, 2015 Glutathione (GSH) is the major scavenger of reactive oxygen species (ROS) inside cells. We used live confocal imaging in order to clarify the role of GSH in the biology of the organ of Corti, the sensory epithelium of the cochlea, before, during and ...
Duchen, MR, Gale, JE, Majumder, P
core +1 more source
The Contribution of Immune Infiltrates to Ototoxicity and Cochlear Hair Cell Loss
Frontiers in Cellular Neuroscience, 2017 Cells of the immune system have been shown to infiltrate the cochlea after acoustic trauma or ototoxic drug treatment; however, the contribution of the immune system to hair cell loss in the inner ear is incompletely understood.
Megan B Wood, J. Zuo
semanticscholar +1 more source
Selective deletion of cochlear hair cells causes rapid age-dependent changes in spiral ganglion and cochlear nucleus neurons [PDF]
, 2015 During nervous system development, critical periods are usually defined as early periods during which manipulations dramatically change neuronal structure or function, whereas the same manipulations in mature animals have little or no effect on the same ...
Hume, Clifford +8 more
core +2 more sources
Mitochondrial calcium uptake underlies ROS generation during aminoglycoside-induced hair cell death.
Journal of Clinical Investigation, 2016 Exposure to aminoglycoside antibiotics can lead to the generation of toxic levels of reactive oxygen species (ROS) within mechanosensory hair cells of the inner ear that have been implicated in hearing and balance disorders.
Robert Esterberg +6 more
semanticscholar +1 more source
Transmission Disrupted: Modeling Auditory Synaptopathy in Zebrafish
Frontiers in Cell and Developmental Biology, 2018 Sensorineural hearing loss is the most common form of hearing loss in humans, and results from either dysfunction in hair cells, the sensory receptors of sound, or the neurons that innervate hair cells.
Katie S. Kindt, Lavinia Sheets
doaj +1 more source
A "synaptoplasmic cistern" mediates rapid inhibition of cochlear hair cells [PDF]
, 2004 Cochlear hair cells are inhibited by cholinergic efferent neurons. The acetylcholine (ACh) receptor of the hair cell is a ligand-gated cation channel through which calcium enters to activate potassium channels and hyperpolarize the cell.
Fuchs, Paul A. +7 more
core +1 more source