A Reversal in Hair Cell Orientation Organizes Both the Auditory and Vestibular Organs
Frontiers in Neuroscience, 2021 Sensory hair cells detect mechanical stimuli with their hair bundle, an asymmetrical brush of actin-based membrane protrusions, or stereocilia. At the single cell level, stereocilia are organized in rows of graded heights that confer the hair bundle with
Basile Tarchini +2 more
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Hybrid in vitro diffusion cell for simultaneous evaluation of hair and skin decontamination: temporal distribution of chemical contaminants [PDF]
, 2018 Most casualty or personnel decontamination studies have focused on removing contaminants from the skin. However, scalp hair and underlying skin are the most likely areas of contamination following airborne exposure to chemicals. The aim of this study was
A Roul +21 more
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Apical hair cells and hearing [PDF]
Hearing Research, 1990 This study assessed the contribution of the apical hair cells to hearing. Guinea pigs, chinchillas and monkeys were behaviorally trained using positive reinforcement to respond to pure-tone stimuli. When a stable audiogram had been determined, each subject received one of three experimental treatments: ototoxic drug administration, low-frequency noise ...
Cynthia A. Prosen +7 more
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Hair Cell Transduction, Tuning, and Synaptic Transmission in the Mammalian Cochlea.
Comprehensive Physiology, 2017 Sound pressure fluctuations striking the ear are conveyed to the cochlea, where they vibrate the basilar membrane on which sit hair cells, the mechanoreceptors of the inner ear.
R. Fettiplace
semanticscholar +1 more source
Keratin-mediated hair growth and its underlying biological mechanism
Communications Biology, 2022 Injecting human hair-derived keratin into mice skin accelerates hair growth & formation, as TGFβ2 secretion during hair destruction stimulates epithelial cell death and keratin release, leading to dermal cell condensation & hair growth.
Seong Yeong An +10 more
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Cellular glutathione content in the organ of Corti and its role during ototoxicity. [PDF]
, 2015 Glutathione (GSH) is the major scavenger of reactive oxygen species (ROS) inside cells. We used live confocal imaging in order to clarify the role of GSH in the biology of the organ of Corti, the sensory epithelium of the cochlea, before, during and ...
Duchen, MR, Gale, JE, Majumder, P
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Molecular characterization and prospective isolation of human fetal cochlear hair cell progenitors
Nature Communications, 2018 Sensory hair cells located in the organ of Corti are essential for cochlear mechanosensation. Their loss is irreversible in humans resulting in permanent hearing loss.
M. Roccio +5 more
semanticscholar +1 more source
Olfactory receptor OR2AT4 regulates human hair growth
Nature Communications, 2018 Increasing evidence suggest that olfactory receptors can carry additional functions besides olfaction. Here, Chéret et al. show that stimulation of the olfactory receptor ORT2A4 by the odorant Sandalore® stimulates growth of human scalp hair follicles ex
Jérémy Chéret +7 more
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Activated notch causes deafness by promoting a supporting cell phenotype in developing auditory hair cells. [PDF]
PLoS ONE, 2014 To determine whether activated Notch can promote a supporting cell fate during sensory cell differentiation in the inner ear.An activated form of the Notch1 receptor (NICD) was expressed in early differentiating hair cells using a Gfi1-Cre mouse allele ...
Grace Savoy-Burke +7 more
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Selective deletion of cochlear hair cells causes rapid age-dependent changes in spiral ganglion and cochlear nucleus neurons [PDF]
, 2015 During nervous system development, critical periods are usually defined as early periods during which manipulations dramatically change neuronal structure or function, whereas the same manipulations in mature animals have little or no effect on the same ...
Hume, Clifford +8 more
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