Outer Hair Cells and Electromotility [PDF]
Cold Spring Harbor Perspectives in Medicine, 2018 Outer hair cells (OHCs) of the mammalian cochlea behave like actuators: they feed energy into the cochlear partition and determine the overall mechanics of hearing. They do this by generating voltage-dependent axial forces. The resulting change in the cell length, observed by microscopy, has been termed "electromotility." The mechanism of force ...
openaire +4 more sources
A "synaptoplasmic cistern" mediates rapid inhibition of cochlear hair cells [PDF]
, 2004 Cochlear hair cells are inhibited by cholinergic efferent neurons. The acetylcholine (ACh) receptor of the hair cell is a ligand-gated cation channel through which calcium enters to activate potassium channels and hyperpolarize the cell.
Fuchs, Paul A. +7 more
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Gene Therapy Restores Hair Cell Stereocilia Morphology in Inner Ears of Deaf Whirler Mice.
Molecular Therapy, 2016 Hereditary deafness is one of the most common disabilities affecting newborns. Many forms of hereditary deafness are caused by morphological defects of the stereocilia bundles on the apical surfaces of inner ear hair cells, which are responsible for ...
W. Chien +8 more
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Advances in stem cell-based therapy for hair loss [PDF]
CellR4, 2020 Hair loss is a quite common condition observed in both men and women. Pattern hair loss also known as androgenetic alopecia is the most common form of hair loss that is thought to affect up to 80% of Caucasian men and up to 40% of Caucasian women by age ...
A. Egger, M. Tomic-Canic, A. Tosti
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A Novel Antigen Sensitive to Calcium Chelation That is Associated with the Tip Links and Kinocilial Links of Sensory Hair Bundles [PDF]
, 2003 Tip links are extracellular, cell-surface-associated filaments of unknown molecular composition that are thought to gate the mechanotransducer channel of the sensory hair cell.
Goodyear, Richard J, Richardson, Guy P
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Defective Tmprss3-Associated Hair Cell Degeneration in Inner Ear Organoids [PDF]
, 2019 Mutations in the gene encoding the type II transmembrane protease 3 (TMPRSS3) cause human hearing loss, although the underlying mechanisms that result in TMPRSS3-related hearing loss are still unclear.
Alex, Alpha L. +8 more
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The role of extracellular vesicles in cutaneous remodeling and hair follicle dynamics [PDF]
, 2019 Extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies, are cell-derived membranous structures that were originally catalogued as a way of releasing cellular waste products.
Carrasco, Elisa +2 more
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Journal of Neuroscience, 2015 Macrophages are recruited into the cochlea in response to injury caused by acoustic trauma or ototoxicity, but the nature of the interaction between macrophages and the sensory structures of the inner ear remains unclear.
Tejbeer Kaur +6 more
semanticscholar +1 more source
Transmitter release from cochlear hair cells is phase locked to cyclic stimuli of different intensities and frequencies [PDF]
, 2012 The auditory system processes time and intensity through separate brainstem pathways to derive spatial location as well as other salient features of sound.
Goutman, Juan Diego
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Activation of PI3K signaling prevents aminoglycoside-induced hair cell death in the murine cochlea
Biology Open, 2016 Loss of sensory hair cells of the inner ear due to aminoglycoside exposure is a major cause of hearing loss. Using an immortalized multipotent otic progenitor (iMOP) cell line, specific signaling pathways that promote otic cell survival were identified ...
Azadeh Jadali, Kelvin Y. Kwan
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